about
The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targetsActivation of Src and transformation by an RPTPα splice mutant found in human tumoursAlternative splicing for diseases, cancers, drugs, and databasesMicrobial and Natural Metabolites That Inhibit Splicing: A Powerful Alternative for Cancer TreatmentIdentification of single- and multiple-class specific signature genes from gene expression profiles by group marker indexA genome-wide systematic analysis reveals different and predictive proliferation expression signatures of cancerous vs. non-cancerous cellsApplying NGS Data to Find Evolutionary Network Biomarkers from the Early and Late Stages of Hepatocellular Carcinoma.A novel human heparanase splice variant, T5, endowed with protumorigenic characteristics.The role of mRNA splicing in prostate cancer.On the road with WRAP53β: guardian of Cajal bodies and genome integrityThe pre-mRNA splicing machinery of trypanosomes: complex or simplified?Total Synthesis and Biological Studies of TMC-205 and Analogues as Anticancer Agents and Activators of SV40 Promoter.Evolution of network biomarkers from early to late stage bladder cancer samples.Identification of novel deregulated RNA metabolism-related genes in non-small cell lung cancer.Clinical significance of heparanase splice variant (t5) in renal cell carcinoma: evaluation by a novel t5-specific monoclonal antibodyApoptosis of human melanoma cells induced by inhibition of B-RAFV600E involves preferential splicing of bimSEnantioselective synthesis of spliceostatin E and evaluation of biological activity.Identification of a new Schistosoma mansoni SMYB1 partner: putative roles in RNA metabolism.Tumor antigens as proteogenomic biomarkers in invasive ductal carcinomas.The spliceosomal PRP19 complex of trypanosomesComputational discovery of pathway-level genetic vulnerabilities in non-small-cell lung cancer.Jerantinine A induces tumor-specific cell death through modulation of splicing factor 3b subunit 1 (SF3B1)Multiple components of the spliceosome regulate Mcl1 activity in neuroblastoma.Neuraminidase 1 (NEU1) promotes proliferation and migration as a diagnostic and prognostic biomarker of hepatocellular carcinoma.Design, synthesis and in vitro splicing inhibition of desmethyl and carba-derivatives of herboxidieneAlternative pre-mRNA splicing in digestive tract malignancy.Meta-analysis and gene set analysis of archived microarrays suggest implication of the spliceosome in metastatic and hypoxic phenotypes.Antiangiogenic activity of herboxidiene via downregulation of vascular endothelial growth factor receptor-2 and hypoxia-inducible factor-1α.Triomics Analysis of Imatinib-Treated Myeloma Cells Connects Kinase Inhibition to RNA Processing and Decreased Lipid Biosynthesis.Antihepatoma activity of chaetocin due to deregulated splicing of hypoxia-inducible factor 1α pre-mRNA in mice and in vitro.A thermally targeted peptide inhibitor of symmetrical dimethylation inhibits cancer-cell proliferation.Alternative Splicing of Fibroblast Growth Factor Receptor IgIII Loops in Cancer.Stabilized cyclopropane analogs of the splicing inhibitor FD-895Biotinylated quercetin as an intrinsic photoaffinity proteomics probe for the identification of quercetin target proteins.Impairment of pre-mRNA splicing in liver disease: mechanisms and consequences.A phase I, open-label, single-arm, dose-escalation study of E7107, a precursor messenger ribonucleic acid (pre-mRNA) splicesome inhibitor administered intravenously on days 1 and 8 every 21 days to patients with solid tumors.Radiation-induced alternative transcripts as detected in total and polysome-bound mRNA.Enantioselective Synthesis of Spliceostatin G and Evaluation of Bioactivity of Spliceostatin G and Its Methyl Ester.
P2860
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P2860
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
The spliceosome as target for anticancer treatment.
@en
The spliceosome as target for anticancer treatment.
@nl
type
label
The spliceosome as target for anticancer treatment.
@en
The spliceosome as target for anticancer treatment.
@nl
prefLabel
The spliceosome as target for anticancer treatment.
@en
The spliceosome as target for anticancer treatment.
@nl
P2093
P2860
P921
P356
P1476
The spliceosome as target for anticancer treatment.
@en
P2093
E A C Wiemer
F A L M Eskens
R J van Alphen
P2860
P2888
P304
P356
10.1038/SJ.BJC.6604801
P407
P577
2008-11-25T00:00:00Z
2009-01-27T00:00:00Z
P5875
P6179
1010685642