Inhibitor of apoptosis proteins in hematological malignancies.
about
Smac mimetic bypasses apoptosis resistance in FADD- or caspase-8-deficient cells by priming for tumor necrosis factor α-induced necroptosisRIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosisApoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategiesLocalization and upregulation of survivin in cancer health disparities: a clinical perspectiveInhibitors of apoptosis proteins (IAPs) expression and their prognostic significance in hepatocellular carcinoma.Expression of executioner procaspases and their activation by a procaspase-activating compound in chronic lymphocytic leukemia cellsMicroRNA regulation and therapeutic targeting of survivin in cancer.Apoptotic cell signaling in cancer progression and therapyQuercetin-mediated Mcl-1 and survivin downregulation restores TRAIL-induced apoptosis in non-Hodgkin's lymphoma B cells.Influence of survivin-targeted therapy on chemosensitivity in the treatment of acute myeloid leukemia.Survivin is highly expressed in CD34(+)38(-) leukemic stem/progenitor cells and predicts poor clinical outcomes in AMLMolecular pathways: turning proteasomal protein degradation into a unique treatment approach.Towards novel paradigms for cancer therapy.Monitoring survivin expression in cancer: implications for prognosis and therapy.Apoptosis and molecular targeting therapy in cancer.Deregulated apoptosis signaling in core-binding factor leukemia differentiates clinically relevant, molecular marker-independent subgroups.Requirement of nuclear factor κB for Smac mimetic-mediated sensitization of pancreatic carcinoma cells for gemcitabine-induced apoptosis.Novel second mitochondria-derived activator of caspases (Smac) mimetic compounds sensitize human leukemic cell lines to conventional chemotherapeutic drug-induced and death receptor-mediated apoptosis.Overexpression of survivin initiates hematologic malignancies in vivoSmac mimetic LCL161 supports neuroblastoma chemotherapy in a drug class-dependent manner and synergistically interacts with ALK inhibitor TAE684 in cells with ALK mutation F1174L.SMAC Mimetic BV6 Enables Sensitization of Resistant Tumor Cells but also Affects Cytokine-Induced Killer (CIK) Cells: A Potential Challenge for Combination Therapy.Targeting apoptosis signaling pathways for anticancer therapySensitization of neuroblastoma for vincristine-induced apoptosis by Smac mimetic LCL161 is attended by G2 cell cycle arrest but is independent of NFκB, RIP1 and TNF-α.Single agent and synergistic combinatorial efficacy of first-in-class small molecule imipridone ONC201 in hematological malignancies.
P2860
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P2860
Inhibitor of apoptosis proteins in hematological malignancies.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Inhibitor of apoptosis proteins in hematological malignancies.
@en
Inhibitor of apoptosis proteins in hematological malignancies.
@nl
type
label
Inhibitor of apoptosis proteins in hematological malignancies.
@en
Inhibitor of apoptosis proteins in hematological malignancies.
@nl
prefLabel
Inhibitor of apoptosis proteins in hematological malignancies.
@en
Inhibitor of apoptosis proteins in hematological malignancies.
@nl
P2860
P356
P1433
P1476
Inhibitor of apoptosis proteins in hematological malignancies.
@en
P2860
P2888
P304
P356
10.1038/LEU.2008.329
P50
P577
2008-11-27T00:00:00Z