20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.
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Cytochrome P450 eicosanoids in hypertension and renal diseaseEffects of 5,14-HEDGE, a 20-HETE mimetic, on lipopolysaccharide-induced changes in MyD88/TAK1/IKKβ/IκB-α/NF-κB pathway and circulating miR-150, miR-223, and miR-297 levels in a rat model of septic shock.G-protein βγ subunit dimers modulate kidney repair after ischemia-reperfusion injury in rats.20-HETE-producing enzymes are up-regulated in human cancers.Targeting 20-HETE producing enzymes in cancer - rationale, pharmacology, and clinical potential20-Hydroxyeicosatetraenoic acid involved in endothelial activation and thrombosis.20-HETE Signals Through G-Protein-Coupled Receptor GPR75 (Gq) to Affect Vascular Function and Trigger Hypertension.20-HETE in acute kidney injury.Localization and expression profile of Group I and II Activators of G-protein Signaling in the kidneyCytochrome P450 1B1 contributes to renal dysfunction and damage caused by angiotensin II in mice.Attenuation of neonatal ischemic brain damage using a 20-HETE synthesis inhibitor20-HETE contributes to ischemia-induced angiogenesis.Epoxides Derived from Dietary Dihomo-Gamma-Linolenic Acid Induce Germ Cell Death in C. elegans.A molecular case report: functional assay of tyrosine kinase inhibitors in cells from a patient's primary renal cell carcinoma.20-HETE Activates the Transcription of Angiotensin-Converting Enzyme via Nuclear Factor-κB Translocation and Promoter Binding5,14-HEDGE, a 20-HETE mimetic, reverses hypotension and improves survival in a rodent model of septic shock: contribution of soluble epoxide hydrolase, CYP2C23, MEK1/ERK1/2/IKKβ/IκB-α/NF-κB pathway, and proinflammatory cytokine formation.Contribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1, and gp91(phox) to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia, and inflammation in a rat model of septic shockNS-398 reverses hypotension in endotoxemic rats: contribution of eicosanoids, NO, and peroxynitrite.Molecular mechanisms and cell signaling of 20-hydroxyeicosatetraenoic acid in vascular pathophysiology.Clinical Implications of 20-Hydroxyeicosatetraenoic Acid in the Kidney, Liver, Lung and Brain: An Emerging Therapeutic TargetRole of cytochrome P450-mediated arachidonic acid metabolites in the pathogenesis of cardiac hypertrophy.Cytochrome P450 and Lipoxygenase Metabolites on Renal Function.Sclt1 deficiency causes cystic kidney by activating ERK and STAT3 signaling.Effect of Cytochrome P450 Metabolites of Arachidonic Acid in Nephrology.Activator of G-protein Signaling 3 Controls Renal Epithelial Cell Survival and ERK5 Activation.Role of 20-Hydroxyeicosatetraenoic Acid (20-HETE) in Androgen-Mediated Cell Viability in Prostate Cancer Cells.Elevated 20-HETE impairs coronary collateral growth in metabolic syndrome via endothelial dysfunction.GPR75 Identified as the First 20-HETE Receptor: A Chemokine Receptor Adopted by a New Family.
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20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on July 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
20-HETE activates the Raf/MEK/ ...... and c-Src-dependent mechanism.
@en
20-HETE activates the Raf/MEK/ ...... and c-Src-dependent mechanism.
@nl
type
label
20-HETE activates the Raf/MEK/ ...... and c-Src-dependent mechanism.
@en
20-HETE activates the Raf/MEK/ ...... and c-Src-dependent mechanism.
@nl
prefLabel
20-HETE activates the Raf/MEK/ ...... and c-Src-dependent mechanism.
@en
20-HETE activates the Raf/MEK/ ...... and c-Src-dependent mechanism.
@nl
P2093
P2860
P1476
20-HETE activates the Raf/MEK/ ...... and c-Src-dependent mechanism.
@en
P2093
Ellis D Avner
Frank Park
John R Falck
Kevin R Regner
Richard J Roman
Talha Akbulut
P2860
P304
P356
10.1152/AJPRENAL.00146.2009
P577
2009-07-01T00:00:00Z