Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism. - Wikidata - wikimedia - TriplyDB

Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism.

Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism.

http://www.wikidata.org/entity/Q37338980

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LEPROT and LEPROTL1 cooperatively decrease hepatic growth hormone action in mice Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse Acromegaly pathogenesis and treatment Energy metabolism in the liver Bioengineering Thymus Organoids to Restore Thymic Function and Induce Donor-Specific Immune Tolerance to Allografts.Multiple Effects of Growth Hormone in the Body: Is it Really the Hormone for Growth?Tissue-Specific GHR Knockout Mice: Metabolic Phenotypes Prenatal dexamethasone exposure potentiates diet-induced hepatosteatosis and decreases plasma IGF-I in a sex-specific fashion Lipid profiling and transcriptomic analysis reveals a functional interplay between estradiol and growth hormone in liver.The Role of the Growth Hormone/Insulin-Like Growth Factor System in Visceral Adiposity.Biological effects of growth hormone on carbohydrate and lipid metabolism.Circadian clock-coordinated hepatic lipid metabolism: only transcriptional regulation?Metabolic impact of adult-onset, isolated, growth hormone deficiency (AOiGHD) due to destruction of pituitary somatotropes Minireview: mechanisms of growth hormone-mediated gene regulation.A novel effect of growth hormone on macrophage modulates macrophage-dependent adipocyte differentiation.Esterase 1 is a novel transcriptional repressor of growth hormone receptor gene expression: a unique noncatalytic role for a carboxyesterase protein.Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model Preventive effects of chronic exogenous growth hormone levels on diet-induced hepatic steatosis in rats.Hepatic steatosis, low-grade chronic inflammation and hormone/growth factor/adipokine imbalance.Distinct growth hormone receptor signaling modes regulate skeletal muscle development and insulin sensitivity in mice.Disruption of JAK2 in adipocytes impairs lipolysis and improves fatty liver in mice with elevated GH.Exploring the molecular mechanisms underlying the potentiation of exogenous growth hormone on alcohol-induced fatty liver diseases in mice.Evidence of a role for insulin-like growth factor binding protein (IGFBP)-3 in metabolic regulation.Human GH receptor-IGF-1 receptor interaction: implications for GH signaling.DLK1/PREF1 regulates nutrient metabolism and protects from steatosis.Evolution of hepatic steatosis to fibrosis and adenoma formation in liver-specific growth hormone receptor knockout mice Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2.Expression of apoptosis-related genes in liver-specific growth hormone receptor gene-disrupted mice is sex dependent Context-Specific Growth Hormone Signaling through the Transcription Factor STAT5: Implications for the Etiology of Hepatosteatosis and Hepatocellular Carcinoma.Growth hormone and adipose tissue: beyond the adipocyte.Liver-derived IGF-I contributes to GH-dependent increases in lean mass and bone mineral density in mice with comparable levels of circulating GH.Altered metabolism and resistance to obesity in long-lived mice producing reduced levels of IGF-I Gene expression of key regulators of mitochondrial biogenesis is sex dependent in mice with growth hormone receptor deletion in liver.Elevated GH/IGF-I, due to somatotrope-specific loss of both IGF-I and insulin receptors, alters glucose homeostasis and insulin sensitivity in a diet-dependent manner.Osteoblast-restricted Disruption of the Growth Hormone Receptor in Mice Results in Sexually Dimorphic Skeletal Phenotypes.Hepatocyte-specific deletion of Janus kinase 2 (JAK2) protects against diet-induced steatohepatitis and glucose intolerance.Adipose Tissue Redistribution and Ectopic Lipid Deposition in Active Acromegaly and Effects of Surgical Treatment.The intricate role of growth hormone in metabolism.Growth Hormone Inhibits Hepatic De Novo Lipogenesis in Adult Mice Removal of growth hormone receptor (GHR) in muscle of male mice replicates some of the health benefits seen in global GHR-/- mice.

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Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism.

http://www.wikidata.org/entity/Q37338980

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bilimsel makale

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scientific article published on 21 May 2009

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vetenskaplig artikel

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name

Liver-specific deletion of the ...... g in hepatic lipid metabolism.

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Liver-specific deletion of the ...... g in hepatic lipid metabolism.

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Liver-specific deletion of the ...... g in hepatic lipid metabolism.

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Liver-specific deletion of the ...... g in hepatic lipid metabolism.

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Liver-specific deletion of the ...... g in hepatic lipid metabolism.

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Liver-specific deletion of the ...... g in hepatic lipid metabolism.

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JBC.M109.014308

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Journal of Biological Chemistry

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Liver-specific deletion of the ...... g in hepatic lipid metabolism.

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David Hwang

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Derek Le Roith

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Douglas J DiGirolamo

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John J Kopchick

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Mark A Sperling

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Massimo Trucco

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Pinchas Cohen

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Ram K Menon

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Thomas Clemens

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Yong Fan

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P2860

A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse)

Free fatty acids and insulin resistance

Growth hormone regulation of p85alpha expression and phosphoinositide 3-kinase activity in adipose tissue: mechanism for growth hormone-mediated insulin resistance.

Growth hormone and the metabolic syndrome.

Conditional knockout of mouse insulin-like growth factor-1 gene using the Cre/loxP system.

Circulating levels of IGF-1 directly regulate bone growth and density.

Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice.

A model for tissue-specific inducible insulin-like growth factor-I (IGF-I) inactivation to determine the physiological role of liver-derived IGF-I.

Roles of insulin-like growth factor-I and growth hormone in mediating insulin resistance in acromegaly.

Lifelong accumulation of bone in mice lacking Pten in osteoblasts

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19937-19944

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10.1074/JBC.M109.014308

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30

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284

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2009-05-21T00:00:00Z

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19460757

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2740419

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