Tyrosine phosphorylation of growth factor receptor-bound protein-7 by focal adhesion kinase in the regulation of cell migration, proliferation, and tumorigenesis
about
Grb7 binds to Hax-1 and undergoes an intramolecular domain association that offers a model for Grb7 regulationRegulation of insulin and type 1 insulin-like growth factor signaling and action by the Grb10/14 and SH2B1/B2 adaptor proteinsActivation of focal adhesion kinase through an interaction with β4 integrin contributes to tumorigenicity of colon cancerGrb7 upregulation is a molecular adaptation to HER2 signaling inhibition due to removal of Akt-mediated gene repressionIntegrin signaling through FAK in the regulation of mammary stem cells and breast cancerFocal adhesion kinase: a prominent determinant in breast cancer initiation, progression and metastasisGrb7 and Filamin-a associate and are colocalized to cell membrane ruffles upon EGF stimulation.EGF-induced Grb7 recruits and promotes Ras activity essential for the tumorigenicity of Sk-Br3 breast cancer cells.HO-3867, a synthetic compound, inhibits the migration and invasion of ovarian carcinoma cells through downregulation of fatty acid synthase and focal adhesion kinase.Phosphorylation of focal adhesion kinase at Tyr397 in gastric carcinomas and its clinical significance.Focal adhesion kinase and p53 synergistically decrease neuroblastoma cell survival.Gene Expression-Genotype Analysis Implicates GSDMA, GSDMB, and LRRC3C as Contributors to Inflammatory Bowel Disease Susceptibility.Grb7 Protein Stability Modulated by Pin1 in Association with Cell Cycle ProgressionAn EGFR/Src-dependent β4 integrin/FAK complex contributes to malignancy of breast cancer.Visualizing and manipulating focal adhesion kinase regulation in live cells.Dissecting GRB7-mediated signals for proliferation and migration in HER2 overexpressing breast tumor cells: GTP-ase rules.Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7.Novel roles of Src in cancer cell epithelial-to-mesenchymal transition, vascular permeability, microinvasion and metastasis.Receptor protein-tyrosine phosphatase α regulates focal adhesion kinase phosphorylation and ErbB2 oncoprotein-mediated mammary epithelial cell motility.Non-HER2 signaling pathways activated in resistance to anti-HER2 therapy in breast cancer.U94 of human herpesvirus 6 down-modulates Src, promotes a partial mesenchymal-to-epithelial transition and inhibits tumor cell growth, invasion and metastasis.Context-dependent role of Grb7 in HER2+ve and triple-negative breast cancer cell lines.Interaction of the non-phosphorylated peptide G7-18NATE with Grb7-SH2 domain requires phosphate for enhanced affinity and specificity.Emerging roles of focal adhesion kinase in cancer.Grb7 and Hax1 may colocalize partially to mitochondria in EGF-treated SKBR3 cells and their interaction can affect Caspase3 cleavage of Hax1Dimerization in the Grb7 protein.The adaptors Grb10 and Grb14 are calmodulin-binding proteins.Global Expression Profiling and Pathway Analysis of Mouse Mammary Tumor Reveals Strain and Stage Specific Dysregulated Pathways in Breast Cancer Progression.GRB7 protein over-expression and clinical outcome in breast cancer.Involvement of β1-integrin via PIP complex and FAK/paxillin in dexamethasone-induced human mesenchymal stem cells migration.
P2860
Q24293300-CDF6FC79-A5E5-4B30-9A38-768A50415CC6Q26849720-6A223858-A7BA-489B-83FD-2A85DC030485Q28771754-866C7857-652E-4168-8B18-A8FE6A6292ADQ33528957-E5AEC3D4-1AF3-4C06-994E-56D68C862137Q33766299-2DD6B08B-8C0D-41EF-A8D5-7AAC0DF4AA07Q33789414-EE320F45-69C7-48F9-8DAF-E5DC66F55DEAQ33895854-83AC204E-E09F-489D-A8BF-ADBA60460D6CQ34121550-4E6E427C-BB5B-4D62-9E9E-2DF9711A81D5Q34139276-24FE13CA-B8BA-4C4B-B119-D0F8ACC98C5EQ34162284-6677E85D-C8F7-401E-A23A-2168CF89626AQ35642231-D47606C1-6BC1-4DB4-8D29-686073A9A7C4Q36119638-EA31F35A-CABD-4E10-8AA5-A4C7ECF7998DQ36141267-A1482F54-F695-4438-A40A-EDD06FB6399CQ36262579-86F0D742-22C1-4C25-910F-2ECB8055F9C2Q36724913-690AE5C9-2927-4E19-B7CE-0B0989D61A96Q36758884-9ACBC2E9-A5FB-4309-995F-8603206DE20AQ36964946-BBAC7468-AF8B-4A62-9696-923516C542BBQ37116160-F4D0DC31-248C-4A03-94DA-17ACDD80E333Q37415599-A0EA6015-05C7-471F-88B6-53C92AA3885DQ38591976-ADD5D26D-F503-49F7-922C-1D1C4FED09F2Q38701732-1AA8A689-AC3A-4E75-B84E-8D1ABA398F95Q39030506-6C64C3C3-97CE-4298-93B2-AE1F397FCAC7Q39418443-2D07081D-3C4A-4D2B-AB56-3A3F082194FBQ39611596-687D84D9-DB7B-454C-A236-F6CA74C14A22Q41771691-14C77C65-6642-42DF-A9F5-908C2F25EA8CQ42578562-A632C9C6-D12D-4D8B-BC4D-AFCDE13B4FBEQ51098676-D2DB57AA-1D42-42C3-AFCE-8EFD417812F8Q52715481-B10DC797-B7DC-4008-B758-3D9F7CD8F015Q53464299-7B812894-A433-4493-A0E8-93C27A80134FQ55053167-A39DD4A9-512B-445C-9149-17A3E176EA8F
P2860
Tyrosine phosphorylation of growth factor receptor-bound protein-7 by focal adhesion kinase in the regulation of cell migration, proliferation, and tumorigenesis
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 27 May 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Tyrosine phosphorylation of gr ...... oliferation, and tumorigenesis
@en
Tyrosine phosphorylation of gr ...... liferation, and tumorigenesis.
@nl
type
label
Tyrosine phosphorylation of gr ...... oliferation, and tumorigenesis
@en
Tyrosine phosphorylation of gr ...... liferation, and tumorigenesis.
@nl
prefLabel
Tyrosine phosphorylation of gr ...... oliferation, and tumorigenesis
@en
Tyrosine phosphorylation of gr ...... liferation, and tumorigenesis.
@nl
P2093
P2860
P50
P356
P1476
Tyrosine phosphorylation of gr ...... oliferation, and tumorigenesis
@en
P2093
Jun-Lin Guan
Ling-Ya Huang
Pei-Yu Chu
P2860
P304
20215-20226
P356
10.1074/JBC.M109.018259
P407
P577
2009-05-27T00:00:00Z