Altered Na+ transport after an intracellular alpha-subunit deletion reveals strict external sequential release of Na+ from the Na/K pump.
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ATP1A2 Mutations in Migraine: Seeing through the Facets of an Ion Pump onto the Neurobiology of DiseaseInhibition of K+ transport through Na+, K+-ATPase by capsazepine: role of membrane span 10 of the α-subunit in the modulation of ion gatingHyperpolarization-activated inward leakage currents caused by deletion or mutation of carboxy-terminal tyrosines of the Na+/K+-ATPase {alpha} subunitSodium and proton effects on inward proton transport through Na/K pumps.The two C-terminal tyrosines stabilize occluded Na/K pump conformations containing Na or K ionsThe rapid-onset dystonia parkinsonism mutation D923N of the Na+, K+-ATPase alpha3 isoform disrupts Na+ interaction at the third Na+ site.Selectivity of externally facing ion-binding sites in the Na/K pump to alkali metals and organic cationsProtein kinase A (PKA) phosphorylation of Na+/K+-ATPase opens intracellular C-terminal water pathway leading to third Na+-binding site in molecular dynamics simulationsImportance of the Voltage Dependence of Cardiac Na/K ATPase Isozymes.Na⁺/K⁺-ATPase E960 and phospholemman F28 are critical for their functional interactionArginine substitution of a cysteine in transmembrane helix M8 converts Na+,K+-ATPase to an electroneutral pump similar to H+,K+-ATPaseRoute, mechanism, and implications of proton import during Na+/K+ exchange by native Na+/K+-ATPase pumps.Phosphorylation of the Na+,K+-ATPase and the H+,K+-ATPase.Protonation of key acidic residues is critical for the K⁺-selectivity of the Na/K pump.Intracellular Requirements for Passive Proton Transport through the Na+,K+-ATPase.Functional analysis of human Na(+)/K(+)-ATPase familial or sporadic hemiplegic migraine mutations expressed in Xenopus oocytes.K+ congeners that do not compromise Na+ activation of the Na+,K+-ATPase: hydration of the ion binding cavity likely controls ion selectivity.Relationship between intracellular Na+ concentration and reduced Na+ affinity in Na+,K+-ATPase mutants causing neurological disease.Measuring cation transport by Na,K- and H,K-ATPase in Xenopus oocytes by atomic absorption spectrophotometry: an alternative to radioisotope assays.Ionic leakage underlies a gain-of-function effect of dominant disease mutations affecting diverse P-type ATPases.The CAPOS mutation in ATP1A3 alters Na/K-ATPase function and results in auditory neuropathy which has implications for management.On the effect of hyperaldosteronism-inducing mutations in Na/K pumps.Molecular simulations and free-energy calculations suggest conformation-dependent anion binding to a cytoplasmic site as a mechanism for Na+/K+-ATPase ion selectivity.Functional characterization of a novel C-terminal ATP1A2 mutation causing hemiplegic migraine and epilepsy.Crystal structure of a Na+-bound Na+,K+-ATPase preceding the E1P state
P2860
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P2860
Altered Na+ transport after an intracellular alpha-subunit deletion reveals strict external sequential release of Na+ from the Na/K pump.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 24 August 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Altered Na+ transport after an ...... ase of Na+ from the Na/K pump.
@en
Altered Na+ transport after an ...... ase of Na+ from the Na/K pump.
@nl
type
label
Altered Na+ transport after an ...... ase of Na+ from the Na/K pump.
@en
Altered Na+ transport after an ...... ase of Na+ from the Na/K pump.
@nl
prefLabel
Altered Na+ transport after an ...... ase of Na+ from the Na/K pump.
@en
Altered Na+ transport after an ...... ase of Na+ from the Na/K pump.
@nl
P2093
P2860
P356
P1476
Altered Na+ transport after an ...... ase of Na+ from the Na/K pump.
@en
P2093
Craig Gatto
J Fernando Olivera
Pablo Artigas
Siddhartha Yaragatupalli
P2860
P304
15507-15512
P356
10.1073/PNAS.0903752106
P407
P577
2009-08-24T00:00:00Z