Inhibition of cyclic 3'-5'-guanosine monophosphate-specific phosphodiesterase selectively vasodilates the pulmonary circulation in chronically hypoxic rats.
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Lung vasodilatory response to inhaled iloprost in experimental pulmonary hypertension: amplification by different type phosphodiesterase inhibitors.Increased expression of the cGMP-inhibited cAMP-specific (PDE3) and cGMP binding cGMP-specific (PDE5) phosphodiesterases in models of pulmonary hypertensionRoles of accumulated endogenous nitric oxide synthase inhibitors, enhanced arginase activity, and attenuated nitric oxide synthase activity in endothelial cells for pulmonary hypertension in ratsRole of nitric oxide in heparin-induced attenuation of hypoxic pulmonary vascular remodeling.Adenoviral gene transfer of endothelial nitric-oxide synthase (eNOS) partially restores normal pulmonary arterial pressure in eNOS-deficient miceInhaled agonists of soluble guanylate cyclase induce selective pulmonary vasodilation.Acute haemodynamic response in relation to plasma vardenafil concentrations in patients with pulmonary hypertensionSildenafil, a PDE5 inhibitor, in the treatment of pulmonary hypertension.Inhibitors of cyclic nucleotide phosphodiesterase 3 and 5 as therapeutic agents in heart failure.ULTIMATE-SHF trial (UdenafiL Therapy to Improve symptoMAtology, exercise Tolerance and hEmodynamics in patients with chronic systolic heart failure): study protocol for a randomized, placebo-controlled, double-blind trialInfluence of sildenafil on lung diffusion during exposure to acute hypoxia at rest and during exercise in healthy humansRole of phosphodiesterase 5 in synaptic plasticity and memoryCinaciguat, a soluble guanylate cyclase activator, causes potent and sustained pulmonary vasodilation in the ovine fetus.Clinical use of sildenafil in pulmonary artery hypertension.Role of phosphodiesterases in modulation of BKCa channels in hypertensive pulmonary arterial smooth muscle.Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension.Proof of Principle for a Novel Class of Antihypertensives That Target the Oxidative Activation of PKG Iα (Protein Kinase G Iα).Holding our breath: The emerging and anticipated roles of microRNA in pulmonary hypertensionDipyridamole potentiates pulmonary vasodilation induced by acetylcholine and nitric oxide in the ovine fetus.Effects of dipyridamole and inhaled nitric oxide in pediatric patients with pulmonary hypertension.Noninvasive assessment of acute cardiopulmonary effects of an oral single dose of sildenafil in patients with idiopathic pulmonary hypertension.Urodilatin, a natriuretic peptide stimulating particulate guanylate cyclase, and the phosphodiesterase 5 inhibitor dipyridamole attenuate experimental pulmonary hypertension: synergism upon coapplication.Combination of nonspecific PDE inhibitors with inhaled prostacyclin in experimental pulmonary hypertension.Intravenous dipyridamole enhances the effects of inhaled nitric oxide and prevents rebound pulmonary hypertension in piglets.DA-8159, a new PDE5 inhibitor, attenuates the development of compensatory right ventricular hypertrophy in a rat model of pulmonary hypertension.Stimulation of AQP2 membrane insertion in renal epithelial cells in vitro and in vivo by the cGMP phosphodiesterase inhibitor sildenafil citrate (Viagra).Pulmonary vascular effects of sildenafil on the development of chronic pulmonary hypertension in the ovine fetus.Type V phosphodiesterase inhibition modulates endogenous immunoreactivities of endothelin-1 and endothelial nitric oxide synthase in pulmonary arteries in rats with monocrotaline-induced pulmonary hypertension.Comparative effectiveness of sildenafil for pulmonary hypertension due to left heart disease with HFrEF.Successful Surgical Repair and Perioperative Management of 6-Month-Old With Total Anomalous Pulmonary Venous Return in a Developing Country: Considerations for the Treatment of Pulmonary Hypertension.The PDE inhibitor zaprinast enhances NO-mediated protection against vascular leakage in reperfused lungs.The cGMP-specific phosphodiesterase inhibitor E4021 dilates the pulmonary circulation.Pulmonary and systemic effects of the phosphodiesterase inhibitor dipyridamole in newborn lambs with persistent pulmonary hypertension.
P2860
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P2860
Inhibition of cyclic 3'-5'-guanosine monophosphate-specific phosphodiesterase selectively vasodilates the pulmonary circulation in chronically hypoxic rats.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Inhibition of cyclic 3'-5'-gua ...... n in chronically hypoxic rats.
@en
Inhibition of cyclic 3'-5'-gua ...... n in chronically hypoxic rats.
@nl
type
label
Inhibition of cyclic 3'-5'-gua ...... n in chronically hypoxic rats.
@en
Inhibition of cyclic 3'-5'-gua ...... n in chronically hypoxic rats.
@nl
prefLabel
Inhibition of cyclic 3'-5'-gua ...... n in chronically hypoxic rats.
@en
Inhibition of cyclic 3'-5'-gua ...... n in chronically hypoxic rats.
@nl
P2093
P2860
P356
P1476
Inhibition of cyclic 3'-5'-gua ...... n in chronically hypoxic rats.
@en
P2093
D M Rodman
I F McMurty
P2860
P304
P356
10.1172/JCI118386
P407
P577
1996-01-01T00:00:00Z