The role of the photoreceptor ABC transporter ABCA4 in lipid transport and Stargardt macular degeneration.
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Chloroquine treatment of ARPE-19 cells leads to lysosome dilation and intracellular lipid accumulation: possible implications of lysosomal dysfunction in macular degenerationDifferential phospholipid substrates and directional transport by ATP-binding cassette proteins ABCA1, ABCA7, and ABCA4 and disease-causing mutantsStructural Features of the ATP-Binding Cassette (ABC) Transporter ABCA3Mammalian P4-ATPases and ABC transporters and their role in phospholipid transportRetina, retinol, retinal and the natural history of vitamin A as a light sensorGene therapy of inherited retinal degenerations: prospects and challengesA comprehensive review of retinal gene therapyThe lipid translocase, ABCA4: seeing is believing.Chemistry of the retinoid (visual) cycleThe population genomics of rhesus macaques (Macaca mulatta) based on whole-genome sequencesPhospholipid meets all-trans-retinal: the making of RPE bisretinoidsAutosomal recessive retinitis pigmentosa with early macular affectation caused by premature truncation in PROM1.Interaction of extracellular domain 2 of the human retina-specific ATP-binding cassette transporter (ABCA4) with all-trans-retinalThe ATP-binding cassette transporter ABCA4: structural and functional properties and role in retinal disease.Loss of lysophosphatidylcholine acyltransferase 1 leads to photoreceptor degeneration in rd11 mice.Deducing the pathogenic contribution of recessive ABCA4 alleles in an outbred populationDefective lipid transport and biosynthesis in recessive and dominant Stargardt macular degenerationIdentification of genetic variation and haplotype structure of the canine ABCA4 gene for retinal disease association studiesAssessment of canine BEST1 variations identifies new mutations and establishes an independent bestrophinopathy model (cmr3).Opsin is a phospholipid flippasePosttranslational modifications of the photoreceptor-specific ABC transporter ABCA4Membrane receptors and transporters involved in the function and transport of vitamin A and its derivatives.The bisretinoids of retinal pigment epitheliumRescuing Trafficking Mutants of the ATP-binding Cassette Protein, ABCA4, with Small Molecule Correctors as a Treatment for Stargardt Eye Disease.Lipofuscin and N-retinylidene-N-retinylethanolamine (A2E) accumulate in retinal pigment epithelium in absence of light exposure: their origin is 11-cis-retinal.Nanoparticle-motivated gene delivery for ophthalmic applicationPhotoreceptors at a glance.Genomic screening of ABCA4 and array CGH analysis underline the genetic variability of Greek patients with inherited retinal diseases.The retina rapidly incorporates ingested C20-D₃-vitamin A in a swine model.Clinical and genetic analyses reveal novel pathogenic ABCA4 mutations in Stargardt disease families.Localization, purification, and functional reconstitution of the P4-ATPase Atp8a2, a phosphatidylserine flippase in photoreceptor disc membranes.Limited roles of Rdh8, Rdh12, and Abca4 in all-trans-retinal clearance in mouse retina.Outcome of ABCA4 microarray screening in routine clinical practice.Novel compound heterozygous mutations in ABCA4 in a Chinese pedigree with Stargardt disease.ATP-binding cassette transporter ABCA4 and chemical isomerization protect photoreceptor cells from the toxic accumulation of excess 11-cis-retinal.Sterols and sphingolipids: dynamic duo or partners in crime?Cyclic nucleotide compartmentalization: contributions of phosphodiesterases and ATP-binding cassette transporters.An overview of inborn errors of complex lipid biosynthesis and remodelling.The clinical spectrum of inherited diseases involved in the synthesis and remodeling of complex lipids. A tentative overview.Involvement of endoplasmic reticulum stress in all-trans-retinal-induced retinal pigment epithelium degeneration.
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The role of the photoreceptor ABC transporter ABCA4 in lipid transport and Stargardt macular degeneration.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 20 February 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The role of the photoreceptor ...... targardt macular degeneration.
@en
The role of the photoreceptor ...... targardt macular degeneration.
@nl
type
label
The role of the photoreceptor ...... targardt macular degeneration.
@en
The role of the photoreceptor ...... targardt macular degeneration.
@nl
prefLabel
The role of the photoreceptor ...... targardt macular degeneration.
@en
The role of the photoreceptor ...... targardt macular degeneration.
@nl
P2093
P2860
P1476
The role of the photoreceptor ...... targardt macular degeneration.
@en
P2093
Faraz Quazi
Ming Zhong
Robert S Molday
P2860
P304
P356
10.1016/J.BBALIP.2009.02.004
P407
P577
2009-02-20T00:00:00Z