Thrombin receptor activation elicits rapid protein tyrosine phosphorylation and stimulation of the raf-1/MAP kinase pathway preceding delayed mitogenesis in cultured rat aortic smooth muscle cells: evidence for an obligate autocrine mechanism promot

Thrombin receptor activation elicits rapid protein tyrosine phosphorylation and stimulation of the raf-1/MAP kinase pathway preceding delayed mitogenesis in cultured rat aortic smooth muscle cells: evidence for an obligate autocrine mechanism promot

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http://www.wikidata.org/entity/Q37352355

Q37352355

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Epiregulin is a potent vascular smooth muscle cell-derived mitogen induced by angiotensin II, endothelin-1, and thrombin Thrombin inhibits tumor cell growth in association with up-regulation of p21(waf/cip1) and caspases via a p53-independent, STAT-1-dependent pathway Integrin alphavbeta3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis Purification and identification of secreted oxidative stress-induced factors from vascular smooth muscle cells Agonist-stimulated cytoskeletal reorganization and signal transduction at focal adhesions in vascular smooth muscle cells require c-Src.Activation-dependent exposure of the inter-EGF sequence Leu83-Leu88 in factor Xa mediates ligand binding to effector cell protease receptor-1.Hypotension and inflammatory cytokine gene expression triggered by factor Xa-nitric oxide signaling.Factor Xa as an interface between coagulation and inflammation. Molecular mimicry of factor Xa association with effector cell protease receptor-1 induces acute inflammation in vivo.Stimulation of activin A expression in rat aortic smooth muscle cells by thrombin and angiotensin II correlates with neointimal formation in vivo.Requirement for binding of catalytically active factor VIIa in tissue factor-dependent experimental metastasis.Involvement of ERK1/2 kinase in insulin-and thrombin-stimulated vascular smooth muscle cell proliferation.Epistatic effects of multiple receptor genes on pathophysiology of asthma - its limits and potential for clinical application.Autocrine production of basic fibroblast growth factor translated from novel synthesized mRNA mediates thrombin-induced mitogenesis in smooth muscle cells.Tryptase's potent mitogenic effects in human airway smooth muscle cells are via nonproteolytic actions.Evidence for ERK1/2 activation by thrombin that is independent of EGFR transactivation.Thrombin up-regulates tissue factor pathway inhibitor-2 synthesis through a cyclooxygenase-2-dependent, epidermal growth factor receptor-independent mechanism.Thrombin aivation of the 9E3/CEF4 chemokine involves tyrosine kinases including c-src and the epidermal growth factor receptor.The response of smooth muscle cells to alpha-thrombin depends on its arterial origin: comparison among different species.High glucose and insulin inhibit VSMC MKP-1 expression by blocking iNOS via p38 MAPK activation.

P2860

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P2860

Thrombin receptor activation elicits rapid protein tyrosine phosphorylation and stimulation of the raf-1/MAP kinase pathway preceding delayed mitogenesis in cultured rat aortic smooth muscle cells: evidence for an obligate autocrine mechanism promot

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http://www.wikidata.org/entity/Q37352355

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on March 1996

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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