Human T-cell leukemia virus type 2 produces a spliced antisense transcript encoding a protein that lacks a classic bZIP domain but still inhibits Tax2-mediated transcription.
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Highlights on distinctive structural and functional properties of HTLV Tax proteinsHost-pathogen interactome mapping for HTLV-1 and -2 retrovirusesMultifaceted functions and roles of HBZ in HTLV-1 pathogenesisThe Role of HBZ in HTLV-1-Induced OncogenesisRetroviral coinfections: HIV and HTLV: taking stock of more than a quarter century of researchThe need to accessorize: molecular roles of HTLV-1 p30 and HTLV-2 p28 accessory proteins in the viral life cycleHuman endogenous retroviruses and the nervous systemNovel interactions between the HTLV antisense proteins HBZ and APH-2 and the NFAR protein family: Implications for the HTLV lifecyclesConcomitant emergence of the antisense protein gene of HIV-1 and of the pandemic.Human T-cell leukemia virus type 3 (HTLV-3) and HTLV-4 antisense-transcript-encoded proteins interact and transactivate Jun family-dependent transcription via their atypical bZIP motifThe transcription profile of Tax-3 is more similar to Tax-1 than Tax-2: insights into HTLV-3 potential leukemogenic properties.In vivo expression of human T-lymphotropic virus type 1 basic leucine-zipper protein generates specific CD8+ and CD4+ T-lymphocyte responses that correlate with clinical outcome.Discovery and characterization of auxiliary proteins encoded by type 3 simian T-cell lymphotropic virusesThe HIV-1 antisense protein (ASP) induces CD8 T cell responses during chronic infection.Polarized expression of the membrane ASP protein derived from HIV-1 antisense transcription in T cells.Making sense out of antisense transcription in human T-cell lymphotropic viruses (HTLVs).Human T-cell lymphotropic virus type 3 (HTLV-3)- and HTLV-4-derived antisense transcripts encode proteins with similar Tax-inhibiting functions but distinct subcellular localizationHTLV-2 APH-2 expression is correlated with proviral load but APH-2 does not promote lymphocytosis.Distinct transformation tropism exhibited by human T lymphotropic virus type 1 (HTLV-1) and HTLV-2 is the result of postinfection T cell clonal expansion.Human T-cell leukemia virus type 2 antisense viral protein 2 is dispensable for in vitro immortalization but functions to repress early virus replication in vivo.The National Heart, Lung, and Blood Institute retrovirus epidemiology donor studies (Retrovirus Epidemiology Donor Study and Retrovirus Epidemiology Donor Study-II): twenty years of research to advance blood product safety and availability.Comparative host protein interactions with HTLV-1 p30 and HTLV-2 p28: insights into difference in pathobiology of human retroviruses.Temporal regulation of HTLV-2 expression in infected cell lines and patients: evidence for distinct expression kinetics with nuclear accumulation of APH-2 mRNAHIV-1 antisense transcription is preferentially activated in primary monocyte-derived cells.Interplay between the HTLV-2 Tax and APH-2 proteins in the regulation of the AP-1 pathway.Functional Comparison of HBZ and the Related APH-2 Protein Provides Insight into Human T-Cell Leukemia Virus Type 1 Pathogenesis.Permissive Sense and Antisense Transcription from the 5' and 3' Long Terminal Repeats of Human T-Cell Leukemia Virus Type 1Functional comparison of antisense proteins of HTLV-1 and HTLV-2 in viral pathogenesisHuman T lymphotropic virus type 1 SU residue 195 plays a role in determining the preferential CD4+ T cell immortalization/transformation tropismHTLV-1 bZIP factor supports proliferation of adult T cell leukemia cells through suppression of C/EBPα signalingDiscovery and significance of new human T-lymphotropic viruses: HTLV-3 and HTLV-4.Distinct functions of HTLV-1 Tax1 from HTLV-2 Tax2 contribute key roles to viral pathogenesis.Intracellular localization and cellular factors interaction of HTLV-1 and HTLV-2 Tax proteins: similarities and functional differences.Human T-lymphotropic virus type 1 non-structural proteins: Requirements for latent infection.Fine tuning of the temporal expression of HTLV-1 and HTLV-2.HTLV-1 and HTLV-2: highly similar viruses with distinct oncogenic properties.Human T-cell lymphotropic virus type 1 and its oncogenesis.Comparison of the Genetic Organization, Expression Strategies and Oncogenic Potential of HTLV-1 and HTLV-2.Detection of the HIV-1 minus-strand-encoded antisense protein and its association with autophagy.Human T-cell leukaemia virus type 1: parasitism and pathogenesis.
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P2860
Human T-cell leukemia virus type 2 produces a spliced antisense transcript encoding a protein that lacks a classic bZIP domain but still inhibits Tax2-mediated transcription.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 14 July 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
Human T-cell leukemia virus ty ...... s Tax2-mediated transcription.
@en
Human T-cell leukemia virus ty ...... s Tax2-mediated transcription.
@nl
type
label
Human T-cell leukemia virus ty ...... s Tax2-mediated transcription.
@en
Human T-cell leukemia virus ty ...... s Tax2-mediated transcription.
@nl
prefLabel
Human T-cell leukemia virus ty ...... s Tax2-mediated transcription.
@en
Human T-cell leukemia virus ty ...... s Tax2-mediated transcription.
@nl
P2093
P2860
P50
P1433
P1476
Human T-cell leukemia virus ty ...... s Tax2-mediated transcription.
@en
P2093
Benoît Barbeau
Edward L Murphy
Estelle Douceron
Isabelle Clerc
Isabelle Lemasson
Jean-Michel Mesnard
Marilène Halin
Nga Ling Ko
Sébastien Landry
P2860
P304
P356
10.1182/BLOOD-2008-09-179879
P407
P577
2009-07-14T00:00:00Z