Stearoyl CoA desaturase is required to produce active, lipid-modified Wnt proteins.
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Notum deacylates Wnt proteins to suppress signalling activityHepatocyte differentiation of human induced pluripotent stem cells is modulated by stearoyl-CoA desaturase 1 activityNotum is required for neural and head induction via Wnt deacylation, oxidation, and inactivationIdentification of key residues and regions important for porcupine-mediated Wnt acylationFatty acylation of proteins: The long and the short of it.Unsaturated fatty acyl recognition by Frizzled receptors mediates dimerization upon Wnt ligand binding.Allosteric inhibition of a stem cell RNA-binding protein by an intermediary metabolite.Disulfide bond requirements for active Wnt ligands.Concentration-dependent effects of WNTLESS on WNT1/3A signaling.Updating the Wnt pathways.Membrane topology of hedgehog acyltransferase.Hepatic oleate regulates adipose tissue lipogenesis and fatty acid oxidation.Fatty acyl donor selectivity in membrane bound O-acyltransferases and communal cell fate decision-making.Wnt addiction of genetically defined cancers reversed by PORCN inhibition.Regulation of lipid synthesis by the RNA helicase Mov10 controls Wnt5a production.The Wnt signaling pathway in cancer.Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6.Lipid desaturation - the next step in targeting lipogenesis in cancer?Acetyl-CoA carboxylase inhibitors attenuate WNT and Hedgehog signaling and suppress pancreatic tumor growth.Palmitoylation of proteins in cancer.Stearoyl-CoA-desaturase 1 regulates lung cancer stemness via stabilization and nuclear localization of YAP/TAZ.A distinct function of the retinoblastoma protein in the control of lipid composition identified by lipidomic profiling.Divergent effects of Porcupine and Wntless on WNT1 trafficking, secretion, and signaling.Wnt ligand presentation and reception: from the stem cell niche to tissue engineering.Identification of the WNT1 residues required for palmitoylation by Porcupine.Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerizationChemical Probes to Directly Profile Palmitoleoylation of Proteins.Transcriptomic profiling of curcumin-treated human breast stem cells identifies a role for stearoyl-coa desaturase in breast cancer prevention.Pharmacologic Manipulation of Wnt Signaling and Cancer Stem Cells.Oleic acid in the modulation of oocyte and preimplantation embryo development.Stearoyl-CoA desaturase activity in bovine cumulus cells protects the oocyte against saturated fatty acid stress.An in vitro fatty acylation assay reveals a mechanism for Wnt recognition by the acyltransferase Porcupine.Methods for Studying Wnt Protein Modifications/Inactivations by Extracellular Enzymes, Tiki and Notum.From top to bottom: Cell polarity in Hedgehog and Wnt trafficking.
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P2860
Stearoyl CoA desaturase is required to produce active, lipid-modified Wnt proteins.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 19 September 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Stearoyl CoA desaturase is required to produce active, lipid-modified Wnt proteins.
@en
Stearoyl CoA desaturase is required to produce active, lipid-modified Wnt proteins.
@nl
type
label
Stearoyl CoA desaturase is required to produce active, lipid-modified Wnt proteins.
@en
Stearoyl CoA desaturase is required to produce active, lipid-modified Wnt proteins.
@nl
prefLabel
Stearoyl CoA desaturase is required to produce active, lipid-modified Wnt proteins.
@en
Stearoyl CoA desaturase is required to produce active, lipid-modified Wnt proteins.
@nl
P2860
P1433
P1476
Stearoyl CoA desaturase is required to produce active, lipid-modified Wnt proteins.
@en
P2093
Jessica Rios-Esteves
Marilyn D Resh
P2860
P304
P356
10.1016/J.CELREP.2013.08.027
P577
2013-09-19T00:00:00Z