c-Abl-p38α signaling plays an important role in MPTP-induced neuronal death. - Wikidata - wikimedia - TriplyDB

c-Abl-p38α signaling plays an important role in MPTP-induced neuronal death.

c-Abl-p38α signaling plays an important role in MPTP-induced neuronal death.

http://www.wikidata.org/entity/Q37354028

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Activation of tyrosine kinase c-Abl contributes to α-synuclein-induced neurodegeneration Neuroprotective Effects of Loganin on MPTP-Induced Parkinson's Disease Mice: Neurochemistry, Glial Reaction and Autophagy Studies.Autophagy regulates MAVS signaling activation in a phosphorylation-dependent manner in microglia.The c-Abl inhibitor in Parkinson disease.Neuroprotective effects of a Coeloglossum viride var. Bracteatum extract in vitro and in vivo c-Abl inhibition mitigates diet-induced obesity through improving insulin sensitivity of subcutaneous fat in mice.c-Abl and Parkinson's Disease: Mechanisms and Therapeutic Potential.c-Abl-mediated Drp1 phosphorylation promotes oxidative stress-induced mitochondrial fragmentation and neuronal cell death.Phosphorylation of Parkin at serine 131 by p38 MAPK promotes mitochondrial dysfunction and neuronal death in mutant A53T α-synuclein model of Parkinson's disease.Loss of Drosha underlies dopaminergic neuron toxicity in models of Parkinson's disease.The c-Abl inhibitor, Radotinib HCl, is neuroprotective in a preclinical Parkinson's disease mouse model.

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c-Abl-p38α signaling plays an important role in MPTP-induced neuronal death.

http://www.wikidata.org/entity/Q37354028

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 30 October 2015

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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c-Abl-p38α signaling plays an important role in MPTP-induced neuronal death.

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c-Abl-p38α signaling plays an important role in MPTP-induced neuronal death.

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c-Abl-p38α signaling plays an important role in MPTP-induced neuronal death.

@en

c-Abl-p38α signaling plays an important role in MPTP-induced neuronal death.

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c-Abl-p38α signaling plays an important role in MPTP-induced neuronal death.

@en

c-Abl-p38α signaling plays an important role in MPTP-induced neuronal death.

@nl

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Cell Death & Differentiation

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c-Abl-p38α signaling plays an important role in MPTP-induced neuronal death.

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H Chen

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J Ma

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Q He

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Q Liu

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R Wu

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Z Yuan

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P2860

Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

SPAK, a STE20/SPS1-related kinase that activates the p38 pathway

Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function

c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease

p38α MAP kinase dimers with swapped activation segments and a novel catalytic loop conformation

Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response

c-Abl tyrosine kinase modulates tau pathology and Cdk5 phosphorylation in AD transgenic mice

The c-Abl-MST1 signaling pathway mediates oxidative stress-induced neuronal cell death

Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6

Parkinson's disease: mechanisms and models

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542-552

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scholarly article

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10.1038/CDD.2015.135

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