A 2-base pair deletion polymorphism in the partial duplication of the alpha7 nicotinic acetylcholine gene (CHRFAM7A) on chromosome 15q14 is associated with schizophrenia.
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The chimeric gene CHRFAM7A, a partial duplication of the CHRNA7 gene, is a dominant negative regulator of α7*nAChR functionAxonal α7 nicotinic ACh receptors modulate presynaptic NMDA receptor expression and structural plasticity of glutamatergic presynaptic boutonsModulatory effects of α7 nAChRs on the immune system and its relevance for CNS disordersThe human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation, and functionCHRFAM7A, a human-specific and partially duplicated α7-nicotinic acetylcholine receptor gene with the potential to specify a human-specific inflammatory response to injuryStructures and molecular mechanisms for common 15q13.3 microduplications involving CHRNA7: benign or pathological?Pharmacological Characterisation of Nicotinic Acetylcholine Receptors Expressed in Human iPSC-Derived NeuronsTranslational utility of rodent hippocampal auditory gating in schizophrenia research: a review and evaluation.Neuroimmune Interactions in Schizophrenia: Focus on Vagus Nerve Stimulation and Activation of the Alpha-7 Nicotinic Acetylcholine ReceptorCortical parvalbumin GABAergic deficits with α7 nicotinic acetylcholine receptor deletion: implications for schizophrenia.Alexa Fluor 546-ArIB[V11L;V16A] is a potent ligand for selectively labeling alpha 7 nicotinic acetylcholine receptorsGenome-wide association study of copy number variation identified gremlin1 as a candidate gene for lean body massThe duplicated α7 subunits assemble and form functional nicotinic receptors with the full-length α7.Function of partially duplicated human α77 nicotinic receptor subunit CHRFAM7A gene: potential implications for the cholinergic anti-inflammatory response.Deletions flanked by breakpoints 3 and 4 on 15q13 may contribute to abnormal phenotypes.Genomic Copy Number Analysis in Alzheimer's Disease and Mild Cognitive Impairment: An ADNI StudyIsochromosome 13 in a patient with childhood-onset schizophrenia, ADHD, and motor tic disorderA novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder.A Human-Specific α7-Nicotinic Acetylcholine Receptor Gene in Human Leukocytes: Identification, Regulation and the Consequences of CHRFAM7A Expression.New genes drive the evolution of gene interaction networks in the human and mouse genomesThe human clinical phenotypes of altered CHRNA7 copy numberThe effect of α7 nicotinic receptor activation on glutamatergic transmission in the hippocampus.Analysis of copy number variation in Alzheimer's disease: the NIALOAD/ NCRAD Family StudyAssociation between the 2-bp deletion polymorphism in the duplicated version of the alpha7 nicotinic receptor gene and P50 sensory gatingAssociation study of the 2-bp deletion polymorphism in exon 6 of the CHRFAM7A gene with idiopathic generalized epilepsy.Targeting of α7 Nicotinic Acetylcholine Receptors in the Treatment of Schizophrenia and the Use of Auditory Sensory Gating as a Translational BiomarkerMultiple genes in the 15q13-q14 chromosomal region are associated with schizophrenia.Effects of ZNF804A on auditory P300 response in schizophreniaAltered gene expression in the dorsolateral prefrontal cortex of individuals with schizophrenia.Genomics and pharmacogenomics of schizophrenia.Alpha7 neuronal nicotinic receptors as a drug target in schizophrenia.The role of human-specific gene duplications during brain development and evolution.Nicotinic modulation of intrinsic brain networks in schizophrenia.CHRFAM7A: a human-specific α7-nicotinic acetylcholine receptor gene shows differential responsiveness of human intestinal epithelial cells to LPSUnderstanding the Bases of Function and Modulation of α7 Nicotinic Receptors: Implications for Drug Discovery.Targeting neuronal dysfunction in schizophrenia with nicotine: Evidence from neurophysiology to neuroimaging.Effect of alpha7 nicotinic acetylcholine receptor agonists on attentional set-shifting impairment in rats.The current agonists and positive allosteric modulators of α7 nAChR for CNS indications in clinical trials.Microduplication of 15q13.3 and Xq21.31 in a family with Tourette syndrome and comorbidities.
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A 2-base pair deletion polymorphism in the partial duplication of the alpha7 nicotinic acetylcholine gene (CHRFAM7A) on chromosome 15q14 is associated with schizophrenia.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 23 July 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A 2-base pair deletion polymor ...... associated with schizophrenia.
@en
A 2-base pair deletion polymor ...... 7 nicotinic acetylcholine gene
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type
label
A 2-base pair deletion polymor ...... associated with schizophrenia.
@en
A 2-base pair deletion polymor ...... 7 nicotinic acetylcholine gene
@nl
prefLabel
A 2-base pair deletion polymor ...... associated with schizophrenia.
@en
A 2-base pair deletion polymor ...... 7 nicotinic acetylcholine gene
@nl
P2093
P2860
P1433
P1476
A 2-base pair deletion polymor ...... associated with schizophrenia.
@en
P2093
Jennifer Lyon
Judith Gault
Judith Logel
Margaret Short
Melissa L Sinkus
Michael J Lee
Robert Freedman
Sherry Leonard
Susan L Christian
P2860
P356
10.1016/J.BRAINRES.2009.07.041
P407
P577
2009-07-23T00:00:00Z