about
Computational methods in drug discovery.Design and synthesis of new 7-(N-substituted-methyl)-camptothecin derivatives as potent cytotoxic agents.Recent advances in ligand-based drug design: relevance and utility of the conformationally sampled pharmacophore approach.Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseasesSurface modification of polymeric micelles by strain-promoted alkyne-azide cycloadditionsMultifunctional surface modification of gold-stabilized nanoparticles by bioorthogonal reactionsB-ring-aryl substituted luotonin A analogues with a new binding mode to the topoisomerase 1-DNA complex show enhanced cytotoxic activity.Self-defensive nano-assemblies from camptothecin-based antitumor drugsHIFs, angiogenesis, and cancer.From Lead to Drug Utilizing a Mannich Reaction: The Topotecan Story.Camptothecin-7-yl-methanthiole: semisynthesis and biological evaluation.Design and synthesis of novel camptothecin/5-fluorouracil conjugates as cytotoxic agents.Calculated Log D Is Inversely Correlated With Select Camptothecin Clearance and Efficacy in Colon Cancer Xenografts.Semisynthesis, cytotoxic activity, and oral availability of new lipophilic 9-substituted camptothecin derivatives.Mechanistic studies of the modulation of cleavage activity of topoisomerase I by DNA adducts of mono- and bi-functional PtII complexes.Chiral vinylphosphonate and phosphonate analogues of the immunosuppressive agent FTY720.The facile synthesis of the 5Z,9Z-dienoic acids and their topoisomerase I inhibitory activity.Silicon-containing analogs of camptothecin as anticancer agents.An integrated QSAR modeling approach to explore the structure-property and selectivity relationships of N-benzoyl-L-biphenylalanines as integrin antagonists.UVA Irradiation Enhances Brusatol-Mediated Inhibition of Melanoma Growth by Downregulation of the Nrf2-Mediated Antioxidant Response.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Camptothecins: a SAR/QSAR study.
@en
Camptothecins: a SAR/QSAR study.
@nl
type
label
Camptothecins: a SAR/QSAR study.
@en
Camptothecins: a SAR/QSAR study.
@nl
prefLabel
Camptothecins: a SAR/QSAR study.
@en
Camptothecins: a SAR/QSAR study.
@nl
P356
P1433
P1476
Camptothecins: a SAR/QSAR study.
@en
P2093
Rajeshwar P Verma
P304
P356
10.1021/CR0780210
P577
2009-01-01T00:00:00Z