Myofibrillar calcium sensitivity of isometric tension is increased in human dilated cardiomyopathies: role of altered beta-adrenergically mediated protein phosphorylation.
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S100A1: a regulator of myocardial contractilityTransgenic overexpression of the Ca2+-binding protein S100A1 in the heart leads to increased in vivo myocardial contractile performanceWhy does troponin I have so many phosphorylation sites? Fact and fancyExpression of slow skeletal troponin I in adult transgenic mouse heart muscle reduces the force decline observed during acidic conditionsSkeletal muscle contractile protein function is preserved in human heart failureMyofilament Ca2+ sensitization causes susceptibility to cardiac arrhythmia in mice.Force production in mechanically isolated cardiac myocytes from human ventricular muscle tissue.FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility.Molecular and functional characterization of a novel cardiac-specific human tropomyosin isoformProtein Kinases as Drug Development Targets for Heart Disease TherapyLeft ventricular global transcriptional profiling in human end-stage dilated cardiomyopathy.Diastolic dysfunction: insights into pathophysiology and pharmacotherapy.More severe cellular phenotype in human idiopathic dilated cardiomyopathy compared to ischemic heart disease.DCM-related tropomyosin mutants E40K/E54K over-inhibit the actomyosin interaction and lead to a decrease in the number of cycling cross-bridges.Diastolic myofilament dysfunction in the failing human heart.Beneficial effects of SR33805 in failing myocardium.Biochemical and myofilament responses of the right ventricle to severe pulmonary hypertension.10,000-fold concentration increase in proteins in a cascade microchip using anionic ITP by a 3-D numerical simulation with experimental results.Preconcentration and detection of the phosphorylated forms of cardiac troponin I in a cascade microchip by cationic isotachophoresisCardiac myosin binding protein-C is a potential diagnostic biomarker for myocardial infarction.10,000-fold concentration increase of the biomarker cardiac troponin I in a reducing union microfluidic chip using cationic isotachophoresis.Cell-to-cell variability in troponin I phosphorylation in a porcine model of pacing-induced heart failure.In vivo phosphorylation site mapping in mouse cardiac troponin I by high resolution top-down electron capture dissociation mass spectrometry: Ser22/23 are the only sites basally phosphorylated.The use of human cardiac tissue in biophysical research: the risks of translationMolecular defects in cardiac myofibrillar proteins due to thyroid hormone imbalance and diabetes.Myosin cross-bridge dynamics in patients with hypertension and concentric left ventricular remodeling.Myofibrillar remodeling in cardiac hypertrophy, heart failure and cardiomyopathies.Rate-dependent force, intracellular calcium, and action potential voltage alternans are modulated by sarcomere length and heart failure induced-remodeling of thin filament regulation in human heart failure: A myocyte modeling study.Molecule specific effects of PKA-mediated phosphorylation on rat isolated heart and cardiac myofibrillar functionTroponin phosphorylation and myofilament Ca2+-sensitivity in heart failure: increased or decreased?Sarcomere length dependence of power output is increased after PKA treatment in rat cardiac myocytesRegulation of cardiac excitation and contraction by p21 activated kinase-1In vivo phosphorylation of cardiac troponin I by protein kinase Cbeta2 decreases cardiomyocyte calcium responsiveness and contractility in transgenic mouse hearts.Cardiac resynchronization sensitizes the sarcomere to calcium by reactivating GSK-3β.Increased myofilament Ca2+-sensitivity and arrhythmia susceptibility.A study of tropomyosin's role in cardiac function and disease using thin-filament reconstituted myocardium.Cellular and Molecular Aspects of Dyssynchrony and Resynchronization.Protein phosphatase 2A affects myofilament contractility in non-failing but not in failing human myocardiumUsing baculovirus/insect cell expressed recombinant actin to study the molecular pathogenesis of HCM caused by actin mutation A331PEffect of troponin I Ser23/24 phosphorylation on Ca2+-sensitivity in human myocardium depends on the phosphorylation background.
P2860
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P2860
Myofibrillar calcium sensitivity of isometric tension is increased in human dilated cardiomyopathies: role of altered beta-adrenergically mediated protein phosphorylation.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on July 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Myofibrillar calcium sensitivi ...... iated protein phosphorylation.
@en
Myofibrillar calcium sensitivi ...... iated protein phosphorylation.
@nl
type
label
Myofibrillar calcium sensitivi ...... iated protein phosphorylation.
@en
Myofibrillar calcium sensitivi ...... iated protein phosphorylation.
@nl
prefLabel
Myofibrillar calcium sensitivi ...... iated protein phosphorylation.
@en
Myofibrillar calcium sensitivi ...... iated protein phosphorylation.
@nl
P2093
P2860
P356
P1476
Myofibrillar calcium sensitivi ...... iated protein phosphorylation.
@en
P2093
M L Greaser
R M Mentzer
S W Stoker
P2860
P304
P356
10.1172/JCI118762
P407
P577
1996-07-01T00:00:00Z