Evolving potassium channels by means of yeast selection reveals structural elements important for selectivity
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Tuning ion coordination architectures to enable selective partitioningIdentification of yeast proteins necessary for cell-surface function of a potassium channel.Selection of inhibitor-resistant viral potassium channels identifies a selectivity filter site that affects barium and amantadine blockVitamin A transport and the transmembrane pore in the cell-surface receptor for plasma retinol binding proteinRegulation of the desensitization and ion selectivity of ATP-gated P2X2 channels by phosphoinositidesFunctional complementation and genetic deletion studies of KirBac channels: activatory mutations highlight gating-sensitive domainsSearching for interesting channels: pairing selection and molecular evolution methods to study ion channel structure and function.Tethered protein display identifies a novel Kir3.2 (GIRK2) regulator from protein scaffold librariesUsing yeast to study potassium channel function and interactions with small molecules.Electrostatic interactions in the channel cavity as an important determinant of potassium channel selectivity.Multiple modalities converge on a common gate to control K2P channel function.Tuning a potassium channel--the caress of the surroundings.Functional roles of charged amino acid residues on the wall of the cytoplasmic pore of Kir2.1.K+/Na+ selectivity in K channels and valinomycin: over-coordination versus cavity-size constraints.Silencing of the tandem pore domain halothane-inhibited K+ channel 2 (THIK2) relies on combined intracellular retention and low intrinsic activity at the plasma membrane.An essential ligand-binding domain in the membrane receptor for retinol-binding protein revealed by large-scale mutagenesis and a human polymorphism.Endoplasmic reticulum-associated degradation of the renal potassium channel, ROMK, leads to type II Bartter syndrome.Genetic selection of activatory mutations in KcsA.Non-equivalent role of TM2 gating hinges in heteromeric Kir4.1/Kir5.1 potassium channels.The pore helix dipole has a minor role in inward rectifier channel function.Architecture of the HCN selectivity filter and control of cation permeation.K2P potassium channels, mysterious and paradoxically exciting.The endosomal trafficking factors CORVET and ESCRT suppress plasma membrane residence of the renal outer medullary potassium channel (ROMK).Investigating Potassium Channels in Budding Yeast: A Genetic Sandbox
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P2860
Evolving potassium channels by means of yeast selection reveals structural elements important for selectivity
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 22 March 2004
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Evolving potassium channels by ...... ents important for selectivity
@en
Evolving potassium channels by ...... nts important for selectivity.
@nl
type
label
Evolving potassium channels by ...... ents important for selectivity
@en
Evolving potassium channels by ...... nts important for selectivity.
@nl
prefLabel
Evolving potassium channels by ...... ents important for selectivity
@en
Evolving potassium channels by ...... nts important for selectivity.
@nl
P2093
P2860
P356
P1476
Evolving potassium channels by ...... ents important for selectivity
@en
P2093
B Alexander Yi
Christian A Ibarra
Cindy Shen Huang
Lily Yeh Jan
Yu-Fung Lin
Yuh Nung Jan
P2860
P304
P356
10.1073/PNAS.0401195101
P407
P577
2004-03-22T00:00:00Z