A selective EP4 PGE2 receptor agonist alleviates disease in a new mouse model of X-linked nephrogenic diabetes insipidus. - Wikidata - wikimedia - TriplyDB

A selective EP4 PGE2 receptor agonist alleviates disease in a new mouse model of X-linked nephrogenic diabetes insipidus.

A selective EP4 PGE2 receptor agonist alleviates disease in a new mouse model of X-linked nephrogenic diabetes insipidus.

http://www.wikidata.org/entity/Q37363078

about

The Trafficking of the Water Channel Aquaporin-2 in Renal Principal Cells-a Potential Target for Pharmacological Intervention in Cardiovascular Diseases E-type prostanoid receptor 4 (EP4) in disease and therapy A novel therapeutic effect of statins on nephrogenic diabetes insipidus Protein trafficking defects in inherited kidney diseases Combination of secretin and fluvastatin ameliorates the polyuria associated with X-linked nephrogenic diabetes insipidus in mice.High-throughput chemical screening identifies AG-490 as a stimulator of aquaporin 2 membrane expression and urine concentration Activation of prostaglandin E2-EP4 signaling reduces chemokine production in adipose tissue.Vasopressin-independent targeting of aquaporin-2 by selective E-prostanoid receptor agonists alleviates nephrogenic diabetes insipidus.Expression of a dominant negative PKA mutation in the kidney elicits a diabetes insipidus phenotype Disruption of prostaglandin E2 receptor EP4 impairs urinary concentration via decreasing aquaporin 2 in renal collecting ducts.Concordance of changes in metabolic pathways based on plasma metabolomics and skeletal muscle transcriptomics in type 1 diabetes.New insights into the dynamic regulation of water and acid-base balance by renal epithelial cells.Aquaporin 2 promotes cell migration and epithelial morphogenesis.PGE2, Kidney Disease, and Cardiovascular Risk: Beyond Hypertension and Diabetes.Nephrogenic diabetes insipidus: essential insights into the molecular background and potential therapies for treatment.A mouse strain less responsive to dioxin-induced prostaglandin E2 synthesis is resistant to the onset of neonatal hydronephrosis.Metformin, an AMPK activator, stimulates the phosphorylation of aquaporin 2 and urea transporter A1 in inner medullary collecting ducts.Metformin improves urine concentration in rodents with nephrogenic diabetes insipidus.β3 adrenergic receptor in the kidney may be a new player in sympathetic regulation of renal function Wnt5a induces renal AQP2 expression by activating calcineurin signalling pathway.Prostaglandin E2 induces chloride secretion through crosstalk between cAMP and calcium signaling in mouse inner medullary collecting duct cells.Roflumilast and aquaporin-2 regulation in rat renal inner medullary collecting duct.Towards developing new strategies to reduce the adverse side-effects of nonsteroidal anti-inflammatory drugs.Cell culture models and animal models for studying the patho-physiological role of renal aquaporins.Congenital nephrogenic diabetes insipidus: the current state of affairs.Cyclooxygenase metabolites in the kidney.Urinary concentration: different ways to open and close the tap.Dynamic regulation and dysregulation of the water channel aquaporin-2: a common cause of and promising therapeutic target for water balance disorders.Chronic kidney disease: targeting prostaglandin E2 receptors.Pathophysiology, diagnosis and management of nephrogenic diabetes insipidus.The vasopressin type 2 receptor and prostaglandin receptors EP2 and EP4 can increase aquaporin-2 plasma membrane targeting through a cAMP-independent pathway.Physiological insights into novel therapies for nephrogenic diabetes insipidus.Unraveling the Physiology of (Pro)Renin Receptor in the Distal Nephron.Demonstration of the functional impact of vasopressin signaling in the thick ascending limb by a targeted transgenic rat approach.PGE2 receptor EP3 inhibits water reabsorption and contributes to polyuria and kidney injury in a streptozotocin-induced mouse model of diabetes.Antidiuretic Action of Collecting Duct (Pro)Renin Receptor Downstream of Vasopressin and PGE2 Receptor EP4.Prorenin Receptor, a Necessary Component in Urine Concentration Mechanism.Novel activators of aquaporin 2 membrane expression for the treatment of nephrogenic diabetes insipidus: less is more. Focus on "High-throughput chemical screening identifies AG-490 as a stimulator of aquaporin 2 membrane expression and urine concen Effect of PGE2-EPs pathway on primary cultured rat neuron injury caused by aluminum.GRHL2 Is Required for Collecting Duct Epithelial Barrier Function and Renal Osmoregulation.

P2860

Q26768170-FAE4B81D-7C3A-410B-BB1C-069AA9B09267 Q26851156-191E15BA-2E34-487C-86F7-C5A79FF3D5D7 Q27005638-0DC945E8-441F-4DBD-87E3-93ECB9943CD7 Q27012909-DBA2F850-36F1-4D75-AC22-D6D668FF2786 Q33840550-6CC5053D-5645-4963-AB03-43E5F633C4CD Q34295359-4FDBFD00-3CEA-4BA4-B49B-C93DEDAF50E8 Q35014273-0B57CF71-198B-4D04-9F1B-F1ED8A8F75B3 Q35149581-4BE97ED0-CD5D-463B-A02C-CC4B7B3023FA Q35178630-73D062C3-F2A5-4B32-955E-7D1F7E418F0D Q35845853-0471348C-DA16-4C87-BAAE-D5F4366984BB Q35902885-D61054EB-9BA1-42A7-9BE7-5BAE735A6F3F Q35993741-DBD44CE6-CF56-4448-9EB4-E595CBA5EF9A Q36200930-5F37B1CA-9667-42D2-99D7-7CDC6F8659A3 Q36624751-D2B6059C-AC77-41A7-99A9-D461E51A21EF Q36724058-8112F928-A8AF-4911-AEB7-9C78DFB11A5E Q36801701-F0456790-C5AA-41CC-9CC4-01F2765AB362 Q36957103-5B4F9D3F-DE9B-46F6-8AAC-0587445EC2C9 Q37138664-3F50BAEC-8799-4357-8650-9D77E9D4DC06 Q37201204-EB860A5D-57DF-4398-BBF4-F4F91ED91EDC Q37465201-8C13C555-26BC-4BDF-92CC-8EA9DAB3F076 Q37575373-7493A7E4-C46D-4B38-9B1F-B506AA3CAD86 Q37609062-853694DA-5BA6-41B9-A590-4D9820E6566C Q37950890-E5EF335B-5D05-4E41-8F62-6061B010E82C Q37970634-44A4BE09-B75C-43E7-9EFD-13C0974F098D Q37994652-817464C3-E608-468F-B627-FBDC140F7A6B Q38111723-7B306517-F666-4BD7-AA4C-302DEE401A3F Q38111968-A1376B68-59E2-4ADF-A63B-A356C97A53B3 Q38152961-5642603A-263B-4C32-92E8-A6778F30BE08 Q38223323-1C98ECB8-45D8-476A-903D-0A863522DC0D Q38528569-C5636CD3-C93E-4537-A187-4513B1B757CA Q38734391-F3B6B95E-4E93-4F65-84F3-C623435B2D2E Q38930238-3463C622-2B31-4347-8B84-5FD3EA5F931D Q39153429-9965E3A5-0152-4FE4-9747-7FEC6168B1CB Q39680505-CE12AE0D-FA65-4E62-B84E-C7251D74C28A Q39904422-674AD13D-8164-46C0-A535-CC6A581F5CFF Q41645466-99ABC3AB-2F94-44DF-B139-E6C44033730D Q42389546-DB00F5F7-E26A-40AF-8AC5-938F4D5E6A58 Q42931603-FEA2E908-F6D8-4258-9502-3AB8C138377C Q46901630-A9A94C24-F3AD-4562-AD30-51A81DB559D2 Q47315515-9815C708-3791-48E5-B72D-AE9ED14042C6

P2860

A selective EP4 PGE2 receptor agonist alleviates disease in a new mouse model of X-linked nephrogenic diabetes insipidus.

http://www.wikidata.org/entity/Q37363078

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on October 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

A selective EP4 PGE2 receptor ...... ephrogenic diabetes insipidus.

@en

A selective EP4 PGE2 receptor ...... ephrogenic diabetes insipidus.

@nl

type

label

A selective EP4 PGE2 receptor ...... ephrogenic diabetes insipidus.

@en

A selective EP4 PGE2 receptor ...... ephrogenic diabetes insipidus.

@nl

prefLabel

A selective EP4 PGE2 receptor ...... ephrogenic diabetes insipidus.

@en

A selective EP4 PGE2 receptor ...... ephrogenic diabetes insipidus.

@nl

P1433

Q37363078-6034C35A-5009-4777-9392-94C1A8D19489

P1476

Q37363078-67978E63-A95E-4F41-BAD3-D8C3C982C486

P2093

Q37363078-15E40B73-31DE-494A-A594-F120F424BD7C

Q37363078-24909656-AEAB-4E98-836A-F6300BD1EA57

Q37363078-2F783F9A-7F56-4398-B646-CDC8963E33F5

Q37363078-533DEFD0-A848-4606-96C9-98C6CEAAC0FF

Q37363078-97462C24-E92A-488D-B03D-99054638D2FD

Q37363078-B8861094-3ECD-492F-9E2A-DF145C569526

Q37363078-C0BA108C-2B87-474F-91DF-F50D9B6935B6

Q37363078-D3E6E487-DCCB-4119-85DB-644201C0E1D3

Q37363078-D8A6FA05-31D4-4889-9B14-42F91926B079

Q37363078-D9F9D274-A6BC-4A8B-BAB8-31E652AAE065

P2860

Q37363078-14854230-F3CA-4A89-9F5F-CC62741CC052

Q37363078-16E6C863-61A0-4741-AB69-1EDB00D6076F

Q37363078-17611718-9ACD-41D7-BD56-5A6FD935863A

Q37363078-1A35A34E-7B6E-469A-BA53-93A18882B4F8

Q37363078-1BD66F77-0E77-42F7-8A65-21E84E37EA81

Q37363078-201740C9-8A1B-4811-94D9-A84975964324

Q37363078-31324C50-0440-412D-9260-85D84D03F71F

Q37363078-320217D8-7405-4D05-A3A0-3463273A7948

Q37363078-3CB9B021-F74B-4AEB-AEBC-D5F08CE52B04

Q37363078-3DAF48B2-FC34-4B47-84BE-7C146871A6C3

P304

Q37363078-7B9CC634-6567-4548-A6DA-368646603F8E

P31

Q37363078-A102AC59-B3AC-46B5-BAFF-9FC72B272A77

P356

Q37363078-A2F9B906-4715-4EFE-83CC-1425CE2BACF1

P407

Q37363078-832A52AC-5459-42B2-B2F2-5B87E2CFDAB7

P433

Q37363078-95A23E8D-0DB2-4322-AC83-D4D58AAC9718

P478

Q37363078-F4B4DBDE-4FE8-478D-9EA6-AFA04D44D730

P577

Q37363078-9FDED813-9E81-4B51-A5FB-8E413F80F4F4

P698

Q37363078-EA308C19-A446-4E6D-95AC-831E75F1D720

P932

Q37363078-16552889-DF95-4727-BE18-1AFBC175D3A1

P356

P1433

Journal of Clinical Investigation

P1476

A selective EP4 PGE2 receptor ...... ephrogenic diabetes insipidus.

@en

P2093

Bo Li

http://www.w3.org/2001/XMLSchema#string

Christoph Eisner

http://www.w3.org/2001/XMLSchema#string

Chu-Xia Deng

http://www.w3.org/2001/XMLSchema#string

Chung-Lin Chou

http://www.w3.org/2001/XMLSchema#string

Jian Hua Li

http://www.w3.org/2001/XMLSchema#string

Jürgen Schnermann

http://www.w3.org/2001/XMLSchema#string

Jürgen Wess

http://www.w3.org/2001/XMLSchema#string

Mark A Knepper

http://www.w3.org/2001/XMLSchema#string

Oksana Gavrilova

http://www.w3.org/2001/XMLSchema#string

Stasia A Anderson

http://www.w3.org/2001/XMLSchema#string

P2860

Vasopressin increases water permeability of kidney collecting duct by inducing translocation of aquaporin-CD water channels to plasma membrane

Fibroblast growth factor receptor 3 is a negative regulator of bone growth

Bypassing vasopressin receptor signaling pathways in nephrogenic diabetes insipidus

Diabetes insipidus in mice with a mutation in aquaporin-2.

The V2 vasopressin receptor mutations and fluid homeostasis

Peptide and non-peptide agonists and antagonists for the vasopressin and oxytocin V1a, V1b, V2 and OT receptors: research tools and potential therapeutic agents

AVPR2 variants and mutations in nephrogenic diabetes insipidus: review and missense mutation significance

Prostaglandin E2-induced hypertension in conscious dogs

The role of prostaglandin E receptor subtypes (EP1, EP2, EP3, and EP4) in bone resorption: an analysis using specific agonists for the respective EPs

Lethal alpha-thalassaemia created by gene targeting in mice and its genetic rescue

P304

3115-3126

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1172/JCI39680

http://www.w3.org/2001/XMLSchema#string

P407

P433

10

http://www.w3.org/2001/XMLSchema#string

P478

119

http://www.w3.org/2001/XMLSchema#string

P577

2009-10-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

19729836

http://www.w3.org/2001/XMLSchema#string

P932

2752083

http://www.w3.org/2001/XMLSchema#string