Cytokeratin 5 positive cells represent a steroid receptor negative and therapy resistant subpopulation in luminal breast cancers.
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The Obesity-Breast Cancer Conundrum: An Analysis of the IssuesEpithelial-Mesenchymal Transition (EMT) and Regulation of EMT Factors by Steroid Nuclear Receptors in Breast Cancer: A Review and in Silico InvestigationThe network of pluripotency, epithelial-mesenchymal transition, and prognosis of breast cancerSteroid hormones, steroid receptors, and breast cancer stem cellsLive multicellular tumor spheroid models for high-content imaging and screening in cancer drug discovery.Keratin 5 overexpression is associated with serous ovarian cancer recurrence and chemotherapy resistance.The induction of KLF5 transcription factor by progesterone contributes to progesterone-induced breast cancer cell proliferation and dedifferentiation.Loss of primary cilia occurs early in breast cancer development.A high-content assay to identify small-molecule modulators of a cancer stem cell population in luminal breast cancer.Modeling luminal breast cancer heterogeneity: combination therapy to suppress a hormone receptor-negative, cytokeratin 5-positive subpopulation in luminal disease.Progestin suppression of miR-29 potentiates dedifferentiation of breast cancer cells via KLF4.Characterization of the expression of cytokeratins 5, 8, and 14 in mouse thymic epithelial cells during thymus regeneration following acute thymic involution.A flexible reporter system for direct observation and isolation of cancer stem cellsLuminal breast cancer metastases and tumor arousal from dormancy are promoted by direct actions of estradiol and progesterone on the malignant cellsProgesterone downregulation of miR-141 contributes to expansion of stem-like breast cancer cells through maintenance of progesterone receptor and Stat5a.MCF-7 Human Breast Cancer Cells Form Differentiated Microtissues in Scaffold-Free Hydrogels.Maintenance of hormone responsiveness in luminal breast cancers by suppression of NotchProgesterone regulation of stem and progenitor cells in normal and malignant breastHigh-throughput imaging: Focusing in on drug discovery in 3D.The biology of progesterone receptor in the normal mammary gland and in breast cancerTumor initiating but differentiated luminal-like breast cancer cells are highly invasive in the absence of basal-like activity.An immunohistochemical method to study breast cancer cell subpopulations and their growth regulation by hormones in three-dimensional culturesCytokeratin 5-Positive Cells Represent a Therapy Resistant subpopulation in Epithelial Ovarian Cancer.The role of cancer stem cells in breast cancer initiation and progression: potential cancer stem cell-directed therapies.Estrogen switches pure mucinous breast cancer to invasive lobular carcinoma with mucinous features.Progesterone-inducible cytokeratin 5-positive cells in luminal breast cancer exhibit progenitor properties.Heterogeneity of luminal breast cancer characterised by immunohistochemical expression of basal markers.Steroid induction of therapy-resistant cytokeratin-5-positive cells in estrogen receptor-positive breast cancer through a BCL6-dependent mechanism.Targeting CXCR1/2 significantly reduces breast cancer stem cell activity and increases the efficacy of inhibiting HER2 via HER2-dependent and -independent mechanisms.Patient-derived luminal breast cancer xenografts retain hormone receptor heterogeneity and help define unique estrogen-dependent gene signatures.Endocrine disrupting activities of the flavonoid nutraceuticals luteolin and quercetin.Prolactin suppresses a progestin-induced CK5-positive cell population in luminal breast cancer through inhibition of progestin-driven BCL6 expression.Evidence for the existence of triple-negative variants in the MCF-7 breast cancer cell population.Prolactin-Stat5 signaling in breast cancer is potently disrupted by acidosis within the tumor microenvironment.Recent advances reveal IL-8 signaling as a potential key to targeting breast cancer stem cells.Lack of correlation of stem cell markers in breast cancer stem cells.Emerging targeted agents in metastatic breast cancer.Impact of progesterone on stem/progenitor cells in the human breast.Breast cancer stem cells: are we ready to go from bench to bedside?High level PHGDH expression in breast is predominantly associated with keratin 5-positive cell lineage independently of malignancy.
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Cytokeratin 5 positive cells represent a steroid receptor negative and therapy resistant subpopulation in luminal breast cancers.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 28 July 2010
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Cytokeratin 5 positive cells r ...... ion in luminal breast cancers.
@en
Cytokeratin 5 positive cells r ...... ion in luminal breast cancers.
@nl
type
label
Cytokeratin 5 positive cells r ...... ion in luminal breast cancers.
@en
Cytokeratin 5 positive cells r ...... ion in luminal breast cancers.
@nl
prefLabel
Cytokeratin 5 positive cells r ...... ion in luminal breast cancers.
@en
Cytokeratin 5 positive cells r ...... ion in luminal breast cancers.
@nl
P2093
P2860
P1476
Cytokeratin 5 positive cells r ...... ion in luminal breast cancers.
@en
P2093
Anthony Elias
Carol A Sartorius
Christina Finlayson
James M Haughian
Kathryn B Horwitz
Peter Kabos
Wendy W Dye
Xinshuo Wang
P2860
P2888
P356
10.1007/S10549-010-1078-6
P407
P577
2010-07-28T00:00:00Z