Molecular basis of multidrug transport by ABC transporters.
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Mutations in ABCD4 cause a new inborn error of vitamin B12 metabolismVisualizing functional motions of membrane transporters with molecular dynamics simulationsCrystal structure of a heterodimeric ABC transporter in its inward-facing conformationStructures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domainStructural basis for allosteric cross-talk between the asymmetric nucleotide binding sites of a heterodimeric ABC exporter.Tuning the drug efflux activity of an ABC transporter in vivo by in vitro selected DARPin bindersMultiple transport-active binding sites are available for a single substrate on human P-glycoprotein (ABCB1)A role for FACT in repopulation of nucleosomes at inducible genesThe role of Abcb5 alleles in susceptibility to haloperidol-induced toxicity in mice and humansDetermination of the quaternary structure of a bacterial ATP-binding cassette (ABC) transporter in living cellsAn efflux pump is required for siderophore recycling by Pseudomonas aeruginosa.Proteins that bind and move lipids: MsbA and NPC1.The Concise Guide to PHARMACOLOGY 2013/14: transporters.Targeted cytosolic delivery of cell-impermeable compounds by nanoparticle-mediated, light-triggered endosome disruption.Exhaustive sampling of docking poses reveals binding hypotheses for propafenone type inhibitors of P-glycoprotein.Discovery of an auto-regulation mechanism for the maltose ABC transporter MalFGK2A multidrug ABC transporter with a taste for salt.Modulation of a Schistosoma mansoni multidrug transporter by the antischistosomal drug praziquantel.Tissue-specific transcript profiling for ABC transporters in the sequestering larvae of the phytophagous leaf beetle Chrysomela populiMass spectrometry of membrane transporters reveals subunit stoichiometry and interactions.Effect of praziquantel on the differential expression of mouse hepatic genes and parasite ATP binding cassette transporter gene family members during Schistosoma mansoni infectionThe signaling interface of the yeast multidrug transporter Pdr5 adopts a cis conformation, and there are functional overlap and equivalence of the deviant and canonical Q-loop residues.Functional rescue of a misfolded eukaryotic ATP-binding cassette transporter by domain replacement.Protein contacts and ligand binding in the inward-facing model of human P-glycoprotein.Understanding polyspecificity of multidrug ABC transporters: closing in on the gaps in ABCB1ABCB1 transporter and Toll-like receptor 4 in trabecular meshwork cells.Dynamics of a bacterial multidrug ABC transporter in the inward- and outward-facing conformationsApplication of fluorescent dye substrates for functional characterization of ABC multidrug transporters at a single cell level.Characterization and expression profiling of ATP-binding cassette transporter genes in the diamondback moth, Plutella xylostella (L.).What do drug transporters really do?Molecular disruption of the power stroke in the ATP-binding cassette transport protein MsbA.A single active catalytic site is sufficient to promote transport in P-glycoproteinMass spectrometry reveals synergistic effects of nucleotides, lipids, and drugs binding to a multidrug resistance efflux pumpOn the origin of large flexibility of P-glycoprotein in the inward-facing stateCost, effectiveness and environmental relevance of multidrug transporters in sea urchin embryos.Role of CFTR in oxidative stress and suicidal death of renal cells during cisplatin-induced nephrotoxicity.Crucial role for phylogenetically conserved cytoplasmic loop 3 in ABCC4 protein expressionIn silico analysis of the binding of anthelmintics to Caenorhabditis elegansP-glycoprotein 1.Exploring conformational equilibria of a heterodimeric ABC transporter.Multicomponent drug efflux complexes: architecture and mechanism of assembly.
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Molecular basis of multidrug transport by ABC transporters.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 24 December 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Molecular basis of multidrug transport by ABC transporters.
@en
Molecular basis of multidrug transport by ABC transporters.
@nl
type
label
Molecular basis of multidrug transport by ABC transporters.
@en
Molecular basis of multidrug transport by ABC transporters.
@nl
prefLabel
Molecular basis of multidrug transport by ABC transporters.
@en
Molecular basis of multidrug transport by ABC transporters.
@nl
P1476
Molecular basis of multidrug transport by ABC transporters.
@en
P2093
Markus A Seeger
P304
P356
10.1016/J.BBAPAP.2008.12.004
P407
P577
2008-12-24T00:00:00Z