Localized thermodynamic coupling between hydrogen bonding and microenvironment polarity substantially stabilizes proteins.
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Protein backbone engineering as a strategy to advance foldamers toward the frontier of protein-like tertiary structureCryoprotectant Toxicity: Facts, Issues, and QuestionsStructural Consequences of β-Amino Acid Preorganization in a Self-Assembling α/β-Peptide: Fundamental Studies of Foldameric Helix BundlesBlind Prediction of Charged Ligand Binding Affinities in a Model Binding SiteContribution of hydrogen bonds to protein stabilityA high-resolution structure that provides insight into coiled-coil thiodepsipeptide dynamic chemistry13C NMR reveals no evidence of n-π* interactions in proteinsTryptophan-lipid interactions in membrane protein folding probed by ultraviolet resonance Raman and fluorescence spectroscopy.Molecular mechanism for lateral lipid diffusion between the outer membrane external leaflet and a beta-barrel hydrocarbon rulerAn energetic scale for equilibrium H/D fractionation factors illuminates hydrogen bond free energies in proteins.Betaalpha-hairpin clamps brace betaalphabeta modules and can make substantive contributions to the stability of TIM barrel proteins.Computational backbone mutagenesis of Abeta peptides: probing the role of backbone hydrogen bonds in aggregation.Context-dependent effects of asparagine glycosylation on Pin WW folding kinetics and thermodynamics.The intrinsic and extrinsic effects of N-linked glycans on glycoproteostasis.Computational design of a pH-sensitive IgG binding protein.The role of backbone hydrogen bonds in the transition state for protein folding of a PDZ domain.Functionally important aromatic-aromatic and sulfur-π interactions in the D2 dopamine receptor.N-glycosylation of enhanced aromatic sequons to increase glycoprotein stabilityRegulation of protein-ligand binding affinity by hydrogen bond pairing.Mechanistic insights into the bifunctional non-heme iron oxygenase carbapenem synthase by active site saturation mutagenesisIntrinsic Pleckstrin Homology (PH) Domain Motion in Phospholipase C-β Exposes a Gβγ Protein Binding Site.The Dependence of Carbohydrate-Aromatic Interaction Strengths on the Structure of the Carbohydrate.Proline substitution of dimer interface β-strand residues as a strategy for the design of functional monomeric proteins.A model of peptide triazole entry inhibitor binding to HIV-1 gp120 and the mechanism of bridging sheet disruptionOrigin of hydrophobicity and enhanced water hydrogen bond strength near purely hydrophobic solutes.Membrane protein folding: how important are hydrogen bonds?An evaluation of peptide-bond isosteres.Forces stabilizing proteinsRole of Internal Water on Protein Thermal Stability: The Case of Homologous G Domains.Non-additive stabilization by halogenated amino acids reveals protein plasticity on a sub-angstrom scale.Design of self-assembling transmembrane helical bundles to elucidate principles required for membrane protein folding and ion transport.Molecular simulation methods in drug discovery: a prospective outlook.Water isotope effect on the thermostability of a polio viral RNA hairpin: A metadynamics study.Order within disorder: aggrecan chondroitin sulphate-attachment region provides new structural insights into protein sequences classified as disordered.The response of the tandem pore potassium channel TASK-3 (K(2P)9.1) to voltage: gating at the cytoplasmic mouth.Contribution of hydrophobic interactions to protein stability.Impact of strand length on the stability of parallel-β-sheet secondary structure.Detection of native-state nonadditivity in double mutant cycles via hydrogen exchange.New charge-bearing amino acid residues that promote β-sheet secondary structure.Double Hydrogen Bonding between Side Chain Carboxyl Groups in Aqueous Solutions of Poly (β-L-Malic Acid): Implication for the Evolutionary Origin of Nucleic Acids.
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Localized thermodynamic coupling between hydrogen bonding and microenvironment polarity substantially stabilizes proteins.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 14 June 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
Localized thermodynamic coupli ...... tantially stabilizes proteins.
@en
Localized thermodynamic coupli ...... tantially stabilizes proteins.
@nl
type
label
Localized thermodynamic coupli ...... tantially stabilizes proteins.
@en
Localized thermodynamic coupli ...... tantially stabilizes proteins.
@nl
prefLabel
Localized thermodynamic coupli ...... tantially stabilizes proteins.
@en
Localized thermodynamic coupli ...... tantially stabilizes proteins.
@nl
P2860
P50
P356
P1476
Localized thermodynamic coupli ...... tantially stabilizes proteins.
@en
P2093
Daryl A Bosco
P2860
P2888
P304
P356
10.1038/NSMB.1610
P577
2009-06-14T00:00:00Z