Investigating drug-induced mitochondrial toxicity: a biosensor to increase drug safety?
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Primary Mitochondrial Disease and Secondary Mitochondrial Dysfunction: Importance of Distinction for Diagnosis and TreatmentMapping drug physico-chemical features to pathway activity reveals molecular networks linked to toxicity outcomeThymosin beta 4 prevents oxidative stress by targeting antioxidant and anti-apoptotic genes in cardiac fibroblastsSystematic study of mitochondrial toxicity of environmental chemicals using quantitative high throughput screening.Enhanced human tissue microdialysis using hydroxypropyl-ß-cyclodextrin as molecular carrier.Mitochondrial approaches to protect against cardiac ischemia and reperfusion injury.Mechanisms of cell death pathway activation following drug-induced inhibition of mitochondrial complex I.Mitochondrial and nuclear genomics and the emergence of personalized medicineImprovement of Mitochondria Extract from Saccharomyces cerevisiae Characterization in Shotgun Proteomics Using Sheathless Capillary Electrophoresis Coupled to Tandem Mass SpectrometryMitochondria as a target of environmental toxicants.Modulation of mitochondrial bioenergetics in a skeletal muscle cell line model of mitochondrial toxicity.Mechanism-based bioanalysis and biomarkers for hepatic chemical stress.Exploratory safety pharmacology: a new safety paradigm to de-risk drug candidates prior to selection for regulatory science investigations.Mitochondria as a pharmacological target: magnum overview.Mitochondrial channels: ion fluxes and more.Development of hydroxybenzoic-based platforms as a solution to deliver dietary antioxidants to mitochondria.Potentiating role of copper on spatial memory deficit induced by beta amyloid and evaluation of mitochondrial function markers in the hippocampus of rats.A systematic assessment of mitochondrial function identified novel signatures for drug-induced mitochondrial disruption in cells.Induction by arsenate of cell-type-specific cytotoxic effects in nerve and hepatoma cells.Synthesis and characterization of celecoxib derivatives as possible anti-inflammatory, analgesic, antioxidant, anticancer and anti-HCV agents.Toxicity of Atorvastatin on Pancreas Mitochondria: A Justification for Increased Risk of Diabetes Mellitus.Predicting in vivo safety characteristics using physiochemical properties and in vitro assays.Multiple effects of a commercial Roundup® formulation on the soil filamentous fungus Aspergillus nidulans at low doses: evidence of an unexpected impact on energetic metabolism.A Search for Mitochondrial Damage in Alzheimer's Disease Using Isolated Rat Brain Mitochondria.Toxicity of macrolide antibiotics on isolated heart mitochondria: a justification for their cardiotoxic adverse effect.Mechanistic approach for the toxic effects of perfluorooctanoic acid on isolated rat liver and brain mitochondria.Bypassing the compromised mitochondrial electron transport with methylene blue alleviates efavirenz/isoniazid-induced oxidant stress and mitochondria-mediated cell death in mouse hepatocytes.Toxicity of Arsenic (III) on Isolated Liver Mitochondria: A New Mechanistic Approach.Synthesis and biological evaluation of novel urea- and guanidine-based derivatives for the treatment of obesity-related hepatic steatosis.High Throughput-Based Mitochondrial Function Assays by Multi-Parametric Flow Cytometry.Mitochondrial Toxicity.Addressing the selectivity and toxicity of antiviral nucleosides.Effects of mid-respiratory chain inhibition on mitochondrial function in vitro and in vivo.High-content screening of drug-induced mitochondrial impairment in hepatic cells: effects of statins
P2860
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P2860
Investigating drug-induced mitochondrial toxicity: a biosensor to increase drug safety?
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Investigating drug-induced mitochondrial toxicity: a biosensor to increase drug safety?
@en
Investigating drug-induced mitochondrial toxicity: a biosensor to increase drug safety?
@nl
type
label
Investigating drug-induced mitochondrial toxicity: a biosensor to increase drug safety?
@en
Investigating drug-induced mitochondrial toxicity: a biosensor to increase drug safety?
@nl
prefLabel
Investigating drug-induced mitochondrial toxicity: a biosensor to increase drug safety?
@en
Investigating drug-induced mitochondrial toxicity: a biosensor to increase drug safety?
@nl
P2093
P50
P1433
P1476
Investigating drug-induced mitochondrial toxicity: a biosensor to increase drug safety?
@en
P2093
Cláudia V Pereira
Filipa S Carvalho
Nuno G Machado
Susana P Pereira
P356
10.2174/157488609787354440
P577
2009-01-01T00:00:00Z