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Plasmin in nephrotic urine activates the epithelial sodium channelTMEM16A is a Ca(2+) -activated Cl(-) channel expressed in the renal collecting duct.Hypotonicity-induced Renin exocytosis from juxtaglomerular cells requires aquaporin-1 and cyclooxygenase-2Proteinuric diseases with sodium retention: Is plasmin the link?Physiological regulation of epithelial sodium channel by proteolysis.Regulation of renin secretion by renal juxtaglomerular cells.Mechanisms of renal NaCl retention in proteinuric disease.Urinary serine proteases and activation of ENaC in kidney--implications for physiological renal salt handling and hypertensive disorders with albuminuria.Remission of nephrotic syndrome diminishes urinary plasmin content and abolishes activation of ENaC.Physiology and pathophysiology of the plasminogen system in the kidney.Apical serine protease activity is necessary for assembly of a high-resistance renal collecting duct epithelium.Prostasin-dependent activation of epithelial Na+ channels by low plasmin concentrations.Diabetic nephropathy is associated with increased urine excretion of proteases plasmin, prostasin and urokinase and activation of amiloride-sensitive current in collecting duct cells.ATP releasing connexin 30 hemichannels mediate flow-induced calcium signaling in the collecting duct.Chronic treatment with vitamin D lowers arterial blood pressure and reduces endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat.Prostaglandin E2 EP2 and EP4 receptor activation mediates cAMP-dependent hyperpolarization and exocytosis of renin in juxtaglomerular cells.Expression of transcellular and paracellular calcium and magnesium transport proteins in renal and intestinal epithelia during lactation.ALBUMINURIA IN KIDNEY TRANSPLANT RECIPIENTS IS ASSOCIATED WITH INCREASED URINARY SERINE PROTEASES AND ACTIVATION OF THE EPITHELIAL SODIUM CHANNEL.Histamine-dependent prolongation by aldosterone of vasoconstriction in isolated small mesenteric arteries of the mouse.Urine exosomes from healthy and hypertensive pregnancies display elevated level of α-subunit and cleaved α- and γ-subunits of the epithelial sodium channel-ENaC.Albuminuria is associated with an increased prostasin in urine while aldosterone has no direct effect on urine and kidney tissue abundance of prostasin.Urinary plasmin activates collecting duct ENaC current in preeclampsia.Aberrant neuronal differentiation is common in glioma but is associated neither with epileptic seizures nor with better survivalA bacterial display system for effective selection of protein-biotin ligase BirA variants with novel peptide specificityStressed podocytes - Bestrophin-3 is not just Bestrophin-3The genetic background affects the vascular response in T-type calcium channels 3.2 deficient miceAberrant glomerular filtration of urokinase-type plasminogen activator in nephrotic syndrome leads to amiloride-sensitive plasminogen activation in urineT-type Ca(2+) channels facilitate NO-formation, vasodilatation and NO-mediated modulation of blood pressureBiosensor cell assay for measuring real-time aldosterone-induced release of histamine from mesenteric arteriesPlasmin in urine from patients with type 2 diabetes and treatment-resistant hypertension activates ENaC in vitroHydronephrosis is associated with elevated plasmin in urine in pediatric patients and rats and changes in NCC and γ-ENaC abundance in rat kidneyDeficiency of T-type voltage-gated calcium channels results in attenuated weight gain and improved endothelium-dependent dilatation of resistance vessels induced by a high-fat diet in miceH+-ATPase B1 subunit localizes to thick ascending limb and distal convoluted tubule of rodent and human kidneyDietary Na+ intake in healthy humans changes the urine extracellular vesicle prostasin abundance while the vesicle excretion rate, NCC, and ENaC are not alteredNephrotic syndrome is associated with increased plasma K+ concentration, intestinal K+ losses, and attenuated urinary K+ excretion: a study in rats and humansBacterial Peptide Display for the Selection of Novel Biotinylating EnzymesThe epithelial Na+ channel α- and γ-subunits are cleaved at predicted furin-cleavage sites, glycosylated and membrane associated in human kidneyMechanisms of sodium retention in nephrotic syndromeThe acute blood pressure-lowering effect of amiloride is independent of endothelial ENaC and eNOS in humans and miceSodium retention by uPA-plasmin-ENaC in nephrotic syndrome-Authors reply
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