Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation
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Antigen-Specific T-Cell Activation Independently of the MHC: Chimeric Antigen Receptor-Redirected T CellsThe Role of Animal Models in the Study of Hematopoietic Stem Cell Transplantation and GvHD: A Historical OverviewGranzyme A and B-deficient killer lymphocytes are defective in eliciting DNA fragmentation but retain potent in vivo anti-tumor capacity.Improved HSC reconstitution and protection from inflammatory stress and chemotherapy in mice lacking granzyme B.Antigen-specific CD8+ T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin.IL-11 separates graft-versus-leukemia effects from graft-versus-host disease after bone marrow transplantation.The biology of graft-versus-host disease: experimental systems instructing clinical practice.Th2 and Tc2 cells in the regulation of GVHD, GVL, and graft rejection: considerations for the allogeneic transplantation therapy of leukemia and lymphoma.Genetic variants of human granzyme B predict transplant outcomes after HLA matched unrelated bone marrow transplantation for myeloid malignancies.Importance of minor histocompatibility antigen expression by nonhematopoietic tissues in a CD4+ T cell-mediated graft-versus-host disease model.Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease.Cytolytic pathways in haematopoietic stem-cell transplantation.A triple-mutated allele of granzyme B incapable of inducing apoptosis.Antibody- and aptamer-strategies for GvHD prevention.Therapeutic activity of multiple common γ-chain cytokine inhibition in acute and chronic GVHDRoles of CD28, CTLA4, and inducible costimulator in acute graft-versus-host disease in mice.Tracking death dealing by Fas and TRAIL in lymphatic neoplastic disorders: pathways, targets, and therapeutic tools.Inflammatory features of nasal mucosa in smokers with and without COPD.Blocking IL-21 signaling ameliorates xenogeneic GVHD induced by human lymphocytes.Homeostatic expansion and repertoire regeneration of donor T cells during graft versus host disease is constrained by the host environment.Immunomodulation of Selective Naive T Cell Functions by p110δ Inactivation Improves the Outcome of Mismatched Cell Transplantation.IL-21 is critical for GVHD in a mouse modelPathophysiology of acute graft-versus-host disease: recent advances.Expression of endogenous granzyme B in a subset of human primary breast carcinomas.Graft-versus-host disease impairs vaccine responses through decreased CD4+ and CD8+ T cell proliferation and increased perforin-mediated CD8+ T cell apoptosis.T cell repertoire complexity is conserved after LLME treatment of donor lymphocyte infusionsGranzyme C supports efficient CTL-mediated killing late in primary alloimmune responses.Manipulating the immune system for anti-tumor responses and transplant tolerance via mixed hematopoietic chimerism.Role of perforin-mediated cell apoptosis in murine models of infusion-induced bone marrow failure.Homing in on acute graft vs. host disease: tissue-specific T regulatory and Th17 cells.Revisiting graft-versus-host disease models of autoimmunity: new insights in immune regulatory processes.End-organ damage in a mouse model of fulminant liver inflammation requires CD4+ T cell production of IFN-gamma but is independent of Fas.Cytolytic T cells induce ceramide-rich platforms in target cell membranes to initiate graft-versus-host disease.Genetically engineered donor T cells to optimize graft-versus-tumor effects across MHC barriers.IL-21 blockade reduces graft-versus-host disease mortality by supporting inducible T regulatory cell generation.Serine protease inhibitors and cytotoxic T lymphocytes.Cytolytic CD4(+) T cells in viral immunityMouse models of graft-versus-host disease: advances and limitationsCysteine cathepsins as regulators of the cytotoxicity of NK and T cells.A novel multiparametric flow cytometry-based cytotoxicity assay simultaneously immunophenotypes effector cells: comparisons to a 4 h 51Cr-release assay.
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P2860
Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on August 1997
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Perforin/granzyme-dependent an ...... ne bone marrow transplantation
@en
Perforin/granzyme-dependent an ...... e bone marrow transplantation.
@nl
type
label
Perforin/granzyme-dependent an ...... ne bone marrow transplantation
@en
Perforin/granzyme-dependent an ...... e bone marrow transplantation.
@nl
prefLabel
Perforin/granzyme-dependent an ...... ne bone marrow transplantation
@en
Perforin/granzyme-dependent an ...... e bone marrow transplantation.
@nl
P2093
P2860
P356
P1476
Perforin/granzyme-dependent an ...... ne bone marrow transplantation
@en
P2093
J F DiPersio
J H Russell
P2860
P304
P356
10.1172/JCI119606
P407
P577
1997-08-01T00:00:00Z