Mechanical regulation of the proangiogenic factor CCN1/CYR61 gene requires the combined activities of MRTF-A and CREB-binding protein histone acetyltransferase.
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The matricellular protein cysteine-rich protein 61 (CCN1/Cyr61) enhances physiological adaptation of retinal vessels and reduces pathological neovascularization associated with ischemic retinopathyThe matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healingEyeing the Cyr61/CTGF/NOV (CCN) group of genes in development and diseases: highlights of their structural likenesses and functional dissimilaritiesTranscriptional regulation of endothelial dysfunction in atherosclerosis: an epigenetic perspectiveMRTF-A controls vessel growth and maturation by increasing the expression of CCN1 and CCN2.Thymosin β4 Improves Differentiation and Vascularization of EHTs.MKL1 defines the H3K4Me3 landscape for NF-κB dependent inflammatory response.Interplay between CCN1 and Wnt5a in endothelial cells and pericytes determines the angiogenic outcome in a model of ischemic retinopathy.Cellular mechanisms of tissue fibrosis. 8. Current and future drug targets in fibrosis: focus on Rho GTPase-regulated gene transcription.Mitogen-activated protein kinase phosphatase-1 promotes neovascularization and angiogenic gene expressionCCN1/CYR61: the very model of a modern matricellular protein.Shape-induced terminal differentiation of human epidermal stem cells requires p38 and is regulated by histone acetylation.Linking actin dynamics and gene transcription to drive cellular motile functions.Induction of the matricellular protein CCN1 through RhoA and MRTF-A contributes to ischemic cardioprotection.MRTF-A steers an epigenetic complex to activate endothelin-induced pro-inflammatory transcription in vascular smooth muscle cellsFunctional microRNA library screening identifies the hypoxamir miR-24 as a potent regulator of smooth muscle cell proliferation and vascularizationcAMP-induced actin cytoskeleton remodelling inhibits MKL1-dependent expression of the chemotactic and pro-proliferative factor, CCN1.Revisiting the matricellular concept.Rho/MRTF-A-Induced Integrin Expression Regulates Angiogenesis in Differentiated Multipotent Mesenchymal Stem CellsG Protein-Coupled Receptor and RhoA-Stimulated Transcriptional Responses: Links to Inflammation, Differentiation, and Cell Proliferation.Myocardin-related Transcription Factor Regulates Nox4 Protein Expression: LINKING CYTOSKELETAL ORGANIZATION TO REDOX STATE.CCN1/Cyr61-PI3K/AKT signaling promotes retinal neovascularization in oxygen-induced retinopathyConnective tissue growth factor regulates retinal neovascularization through p53 protein-dependent transactivation of the matrix metalloproteinase (MMP)-2 geneMyocardin-Related Transcription Factor A and Yes-Associated Protein Exert Dual Control in G Protein-Coupled Receptor- and RhoA-Mediated Transcriptional Regulation and Cell Proliferation.Cyr61, a matricellular protein, is needed for dendritic arborization of hippocampal neurons.Acquired resistance to zoledronic acid and the parallel acquisition of an aggressive phenotype are mediated by p38-MAP kinase activation in prostate cancer cells.New Insights into the Function of the Matricellular CCN1: an Emerging Target in Proliferative Retinopathies.Megakaryocytic leukemia 1 (MKL1) ties the epigenetic machinery to hypoxia-induced transactivation of endothelin-1.TGFβ receptor I transactivation mediates stretch-induced Pak1 activation and CTGF upregulation in mesangial cellsGenetic modification of corneal neovascularization in Dstn (corn1) mice.Cysteine-rich protein 61 (CCN1) and connective tissue growth factor (CCN2) at the crosshairs of ocular neovascular and fibrovascular disease therapy.Molecular control of vascular development by the matricellular proteins CCN1 (Cyr61) and CCN2 (CTGF).Revisited and revised: is RhoA always a villain in cardiac pathophysiology?Tenascin-C and mechanotransduction in the development and diseases of cardiovascular systemMKL1 is an epigenetic mediator of TNF-α-induced proinflammatory transcription in macrophages by interacting with ASH2.Filamin A interacts with the coactivator MKL1 to promote the activity of the transcription factor SRF and cell migration.Mechanism of irradiation-induced mammary cancer metastasis: A role for SAP-dependent Mkl1 signaling.MKL1 potentiates lung cancer cell migration and invasion by epigenetically activating MMP9 transcription.CRE and SRE mediate LPA-induced CCN1 transcription in mouse aortic smooth muscle cells.The Erk MAP kinase pathway is activated at muscle spindles and is required for induction of the muscle spindle-specific gene Egr3 by neuregulin1.
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P2860
Mechanical regulation of the proangiogenic factor CCN1/CYR61 gene requires the combined activities of MRTF-A and CREB-binding protein histone acetyltransferase.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 20 June 2009
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Mechanical regulation of the p ...... ein histone acetyltransferase.
@en
Mechanical regulation of the p ...... ein histone acetyltransferase.
@nl
type
label
Mechanical regulation of the p ...... ein histone acetyltransferase.
@en
Mechanical regulation of the p ...... ein histone acetyltransferase.
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prefLabel
Mechanical regulation of the p ...... ein histone acetyltransferase.
@en
Mechanical regulation of the p ...... ein histone acetyltransferase.
@nl
P2093
P2860
P356
P1476
Mechanical regulation of the p ...... tein histone acetyltransferase
@en
P2093
Brahim Chaqour
Jawaria Amir
M A Q Siddiqui
Mary Hanna
Stephan W Morris
P2860
P304
23125-23136
P356
10.1074/JBC.M109.019059
P407
P50
P577
2009-06-20T00:00:00Z