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Conserved main-chain peptide distortions: A proposed role for Ile203 in catalysis by dihydrodipicolinate synthaseSubstrate-mediated Stabilization of a Tetrameric Drug Target Reveals Achilles Heel in AnthraxDimerization of Bacterial Diaminopimelate Epimerase Is Essential for CatalysisThe crystal structure of dihydrodipicolinate synthase from Escherichia coli with bound pyruvate and succinic acid semialdehyde: unambiguous resolution of the stereochemistry of the condensation productInhibiting dihydrodipicolinate synthase across species: towards specificity for pathogens?Effects of PPAR gamma ligands on TGF-beta1-induced epithelial-mesenchymal transition in alveolar epithelial cells.Oligomers, fact or artefact? SDS-PAGE induces dimerization of β-amyloid in human brain samples.Inhibition of lysine biosynthesis: an evolving antibiotic strategy.Inhibiting protein-protein interactions as an emerging paradigm for drug discovery.Preparation of diazabicyclo[4.3.0]nonene-based peptidomimeticsMethylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis.Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity.Hormetic potential of methylglyoxal, a side-product of glycolysis, in switching tumours from growth to death.Expression, purification, crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase from Bacillus anthracis in the presence of pyruvateNovel conjugated quinoline-indoles compromise Plasmodium falciparum mitochondrial function and show promising antimalarial activity.Role of 2-oxo and 2-thioxo modifications on the proton affinity of histidine and fragmentation reactions of protonated histidine.Crystallization and preliminary X-ray diffraction analysis of diaminopimelate epimerase from Escherichia coli.Total synthesis of the epidermal growth factor inhibitor (-)-reveromycin B.Two new irreversible inhibitors of dihydrodipicolinate synthase: diethyl (E,E)-4-oxo-2,5-heptadienedioate and diethyl (E)-4-oxo-2-heptenedioate.Heterocyclic inhibitors of dihydrodipicolinate synthase are not competitive.Synthesis of the beta-hydroxydopa-gamma-hydroxy-delta-sulfinylnorvaline component of ustiloxins A and B.Characterisation of dihydrodipicolinate synthase (DHDPS) from Bacillus anthracis.Irreversible inhibition of dihydrodipicolinate synthase by 4-oxo-heptenedioic acid analogues.Synthesis of the side chain cross-linked tyrosine oligomers dityrosine, trityrosine, and pulcherosine.Conformationally constrained diketopimelic acid analogues as inhibitors of dihydrodipicolinate synthase.Characterization and Identification of Dityrosine Cross-Linked Peptides Using Tandem Mass Spectrometry.Synthesis of Peptides by Silver-Promoted Coupling of Carboxylates and Thioamides: Mechanistic Insight from Computational Studies.Copper binding and redox chemistry of the Aβ16 peptide and its variants: insights into determinants of copper-dependent reactivity.Blood-borne amyloid-beta dimer correlates with clinical markers of Alzheimer's disease.Sulfonation of Tyrosine as a Method To Improve Biodistribution of Peptide-Based Radiotracers: Novel 18F-Labeled Cyclic RGD Analogues.Automated preparation of 2-[18 F]fluoropropionate labeled peptides using a flexible, multi-stage synthesis platform (iPHASE Flexlab).A new robust kinetic assay for DAP epimerase activity.Total Synthesis of Ustiloxin D Utilizing an Ammonia-Ugi Reaction.Synthesis and antioxidant capacity of novel stable 5-tellurofuranose derivatives.Structure of olefin-imidacloprid and gas-phase fragmentation chemistry of its protonated form.One-step radiosynthesis of 4-nitrophenyl 2-[(18) F]fluoropropionate ([(18) F]NFP); improved preparation of radiolabeled peptides for PET imaging.A general method for interconversion of boronic acid protecting groups: trifluoroborates as common intermediates.Enantioselective preparation of a stable boronate complex stereogenic only at boron.1,3-Phenylene bis(ketoacid) derivatives as inhibitors of Escherichia coli dihydrodipicolinate synthase.Preparation of the Central Tryptophan Moiety of the Celogentin/Moroidin Family of Anti-Mitotic Cyclic Peptides
P50
Q27652117-18543D6C-0F29-4C15-9BFA-863337D71708Q27658380-26CDFD0E-8257-4AEE-8944-4102D52E4512Q27676487-CD424645-257A-4F7F-97B6-A20D7BD6E4D5Q27678874-4186FDB8-275E-49E0-8E41-869894281F95Q28486779-2887D3F3-325E-4398-8788-A6654AAD5513Q33748854-D2647583-CC67-4488-A5E3-38A3FF4EE1C3Q34564863-AD2D8820-2437-4713-8F7D-23FFBC874635Q34639518-E50CC52F-A9AE-4F55-98ED-1F465B135838Q36738030-6BA18FC2-6902-45F8-B593-E5E26AB2BEDDQ36858900-7CF72250-B5B5-4DF3-BD9C-8624BDBB83B1Q37368367-C5C25C07-C16B-4602-A3A3-3AD731FEE986Q39024713-30B882D4-60F9-4486-8B7E-FAB07ADD87BCQ41718480-D9DB14FC-B4AC-4A87-861C-121CE136666EQ41891679-21F05326-4F25-42BD-8E3E-142C87B764FAQ41925106-C40B58D9-EC4A-4599-BB90-8F89EB1E95E9Q42925418-28381481-8EE1-4CB8-A52E-F5D2D94F8F12Q42938690-7D731450-0FCF-4A57-9FB7-928B25DFF0AEQ43561851-BBC61BD0-B218-48CB-B08D-0CED6592005EQ45248244-2575855F-4B16-48F2-98AC-BA4CE5F852F6Q45280231-672CE1F8-B5B1-435F-851E-C4C7009D162BQ45282975-9BDF2DF2-9394-4F52-9A9A-1AA1C68EE40FQ45930710-26267887-8C19-464C-902C-7C55E28DE36DQ46269408-C5F9D3DC-A77E-405A-B458-5A3981D26FFBQ46668994-2BE934B2-55EF-4EFC-8429-C36E50024AA2Q46852521-5CA906EF-AFC0-4212-B7B1-E64084BF1793Q47737272-8961AF5D-3D8D-4EE4-9B35-ED89D36468D8Q48044465-35E28DC9-1034-4FA4-96E6-F38EB57123DCQ48048483-AD7556DB-A1AA-47DF-9963-CE5A0EFDB5ECQ48211669-4913E29A-CBE4-4B35-8587-65121A38E6DCQ48247438-B483BB5E-E820-4B98-A155-C5C3761C3DF0Q48294611-F5F49610-D71D-4ACD-BCC5-1B5871F8B8B3Q50848952-DC49FB62-527C-4570-BA46-38CFB7B53BB7Q50932660-DD002E62-28D7-4164-A04A-8CD5A587995EQ52674180-1059F351-2D70-4ABD-AA1C-5122E028B343Q52841130-7679393A-CED8-47B5-9710-20656335525DQ53085688-ACEB493D-7EF8-4489-B80B-54F2D94E5420Q53229794-19D3925F-7D61-41A8-B795-D7AB806C5564Q53840506-B769455F-A1C4-4DF3-BA44-AD1A6A2EB9D8Q54341178-E75CB38C-A4CE-4B15-A6D5-9DE4277D9F35Q56805452-DE1D94F7-74A2-4AE5-AC8F-28F9463AE7B2
P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Craig A Hutton
@nl
Craig A Hutton
@sl
Craig A. Hutton
@en
Craig A. Hutton
@es
type
label
Craig A Hutton
@nl
Craig A Hutton
@sl
Craig A. Hutton
@en
Craig A. Hutton
@es
altLabel
Craig A Hutton
@en
prefLabel
Craig A Hutton
@nl
Craig A Hutton
@sl
Craig A. Hutton
@en
Craig A. Hutton
@es
P1053
M-2442-2013
P106
P1153
7005571696
P21
P31
P3829
P496
0000-0002-2353-9258