Combined Bcl-2/mammalian target of rapamycin inhibition leads to enhanced radiosensitization via induction of apoptosis and autophagy in non-small cell lung tumor xenograft model.
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Autophagy modulation as a target for anticancer drug discoveryApoptosis through Bcl-2/Bax and cleaved caspase up-regulation in melanoma treated by boron neutron capture therapyTargeting Bcl-2/Bcl-XL induces antitumor activity in uveal melanoma patient-derived xenograftsp62/SQSTM1 levels predicts radiotherapy resistance in hypopharyngeal carcinomasPhase II study of single-agent navitoclax (ABT-263) and biomarker correlates in patients with relapsed small cell lung cancer.Boron neutron capture therapy induces apoptosis of glioma cells through Bcl-2/Bax.A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2-Beclin1 interaction at endoplasmic reticulum.Effect of celecoxib on inhibiting tumor repopulation during radiotherapy in human FaDu squamous cell carcinomaExpression of Bim, Noxa, and Puma in non-small cell lung cancerCopper-doxorubicin as a nanoparticle cargo retains efficacy with minimal toxicity.Resveratrol enhances ionizing radiation-induced premature senescence in lung cancer cells.NVP-BEZ235, a novel dual PI3K/mTOR inhibitor, enhances the radiosensitivity of human glioma stem cells in vitro.A novel bioluminescence orthotopic mouse model for advanced lung cancer.Galectin-1 is overexpressed in CD133+ human lung adenocarcinoma cells and promotes their growth and invasiveness.Autophagy as a therapeutic target in cancer.Sensitization of BCL-2-expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737Radio-sensitization effect of an mTOR inhibitor, temsirolimus, on lung adenocarcinoma A549 cells under normoxic and hypoxic conditions.AZD2014 Radiosensitizes Oral Squamous Cell Carcinoma by Inhibiting AKT/mTOR Axis and Inducing G1/G2/M Cell Cycle Arrest.Novel therapeutic approaches for small cell lung cancer: the future has arrivedAerosol delivery of beclin1 enhanced the anti-tumor effect of radiation in the lungs of K-rasLA1 mice.ABT-737 reverses the acquired radioresistance of breast cancer cells by targeting Bcl-2 and Bcl-xL.The synergistic effects of traditional Chinese herbs and radiotherapy for cancer treatmentAutophagy inhibition radiosensitizes in vitro, yet reduces radioresponses in vivo due to deficient immunogenic signalling.The Protective Roles of ROS-Mediated Mitophagy on 125I Seeds Radiation Induced Cell Death in HCT116 Cells.Role of Autophagy and Apoptosis in Non-Small-Cell Lung Cancer.Influence of autophagy on the efficacy of radiotherapy.Chemosensitization of prostate cancer by modulating Bcl-2 family proteins.Targeting autophagy during cancer therapy to improve clinical outcomes.Mechanisms of mTOR inhibitor resistance in cancer therapy.The autophagic paradox in cancer therapy.Autophagy and ionizing radiation in tumors: the "survive or not survive" dilemma.Galangin suppresses human laryngeal carcinoma via modulation of caspase-3 and AKT signaling pathways.Radiation-induced autophagy: mechanisms and consequences.Kruppel-like factor 4 inhibits non-small cell lung cancer cell growth and aggressiveness by stimulating transforming growth factor-β1-meidated ERK/JNK/NF-κB signaling pathways.Inhibition of mTOR enhances radiosensitivity of lung cancer cells and protects normal lung cells against radiation.Autophagy is not uniformly cytoprotective: a personalized medicine approach for autophagy inhibition as a therapeutic strategy in non-small cell lung cancer.Pan-mammalian target of rapamycin (mTOR) inhibitor AZD8055 primes rhabdomyosarcoma cells for ABT-737-induced apoptosis by down-regulating Mcl-1 proteinMetastatic SW620 colon cancer cells are primed for death when detached and can be sensitized to anoikis by the BH3-mimetic ABT-737.Effect of dual inhibition of apoptosis and autophagy in prostate cancer.A PCR analysis of the ubiquitin-like conjugation systems in macroautophagy.
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P2860
Combined Bcl-2/mammalian target of rapamycin inhibition leads to enhanced radiosensitization via induction of apoptosis and autophagy in non-small cell lung tumor xenograft model.
description
article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 22 September 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Combined Bcl-2/mammalian targe ...... ll lung tumor xenograft model.
@en
Combined Bcl-2/mammalian targe ...... ll lung tumor xenograft model.
@nl
type
label
Combined Bcl-2/mammalian targe ...... ll lung tumor xenograft model.
@en
Combined Bcl-2/mammalian targe ...... ll lung tumor xenograft model.
@nl
prefLabel
Combined Bcl-2/mammalian targe ...... ll lung tumor xenograft model.
@en
Combined Bcl-2/mammalian targe ...... ll lung tumor xenograft model.
@nl
P2093
P2860
P921
P1476
Combined Bcl-2/mammalian targe ...... ll lung tumor xenograft model.
@en
P2093
Dae Kwang Jung
Kwang Woon Kim
Lauren Rhea Mitchell
Luigi Moretti
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P304
P356
10.1158/1078-0432.CCR-09-0589
P407
P577
2009-09-22T00:00:00Z