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Synthesis and trafficking of prion proteins in cultured cells.

Synthesis and trafficking of prion proteins in cultured cells.

http://www.wikidata.org/entity/Q37373585

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Anchorless 23-230 PrPC interactomics for elucidation of PrPC protective role The novel sorting nexin SNX33 interferes with cellular PrP formation by modulation of PrP shedding Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins Elimination of prions by branched polyamines and implications for therapeutics Molecular Pathological Classification of Neurodegenerative Diseases: Turning towards Precision Medicine α-Cleavage of cellular prion protein Cholesterol balance in prion diseases and Alzheimer's disease Cellular aspects of prion replication in vitro Efficient uptake and dissemination of scrapie prion protein by astrocytes and fibroblasts from adult hamster brain Proteasomes and ubiquitin are involved in the turnover of the wild-type prion protein Interactome analyses identify ties of PrP and its mammalian paralogs to oligomannosidic N-glycans and endoplasmic reticulum-derived chaperones Anti-prion activity of Brilliant Blue G Anti-prion drug mPPIg5 inhibits PrP(C) conversion to PrP(Sc)Cellular phenotyping of secretory and nuclear prion proteins associated with inherited prion diseases The Role of Unfolded Protein Response and Mitogen-Activated Protein Kinase Signaling in Neurodegenerative Diseases with Special Focus on Prion Diseases Effects of FlAsH/tetracysteine (TC) Tag on PrP proteolysis and PrPres formation by TC-scanning.Specific biarsenical labeling of cell surface proteins allows fluorescent- and biotin-tagging of amyloid precursor protein and prion proteins.Live imaging of prions reveals nascent PrPSc in cell-surface, raft-associated amyloid strings and webs Characterization of intracellular dynamics of inoculated PrP-res and newly generated PrP(Sc) during early stage prion infection in Neuro2a cells.Selective processing and metabolism of disease-causing mutant prion proteins.Glimepiride reduces the expression of PrPc, prevents PrPSc formation and protects against prion mediated neurotoxicity in cell lines.Cellular biology of prion diseases.Low density subcellular fractions enhance disease-specific prion protein misfolding.Successful transmission of three mouse-adapted scrapie strains to murine neuroblastoma cell lines overexpressing wild-type mouse prion protein Endogenous proteolytic cleavage of disease-associated prion protein to produce C2 fragments is strongly cell- and tissue-dependent.Amphotericin B inhibits the generation of the scrapie isoform of the prion protein in infected cultures.Deletion of beta-strand and alpha-helix secondary structure in normal prion protein inhibits formation of its protease-resistant isoform.Axonal and transynaptic spread of prions.Overexpression of nonconvertible PrPc delta114-121 in scrapie-infected mouse neuroblastoma cells leads to trans-dominant inhibition of wild-type PrP(Sc) accumulation.Scrapie strains maintain biological phenotypes on propagation in a cell line in culture.Down-regulation of Shadoo in prion infections traces a pre-clinical event inversely related to PrP(Sc) accumulation.Protease-resistant prions selectively decrease Shadoo protein.The role of dimerization in prion replication Prion protein-specific antibodies-development, modes of action and therapeutics application Scrapie prions selectively modify the stress response in neuroblastoma cells Selective re-routing of prion protein to proteasomes and alteration of its vesicular secretion prevent PrP(Sc) formation.Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestation Proteasomal dysfunction and endoplasmic reticulum stress enhance trafficking of prion protein aggregates through the secretory pathway and increase accumulation of pathologic prion protein Molecular neurology of prion disease.Prion diseases: from molecular biology to intervention strategies.

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P2860

Synthesis and trafficking of prion proteins in cultured cells.

http://www.wikidata.org/entity/Q37373585

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on August 1992

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Synthesis and trafficking of prion proteins in cultured cells.

@en

Synthesis and trafficking of prion proteins in cultured cells.

@nl

type

label

Synthesis and trafficking of prion proteins in cultured cells.

@en

Synthesis and trafficking of prion proteins in cultured cells.

@nl

prefLabel

Synthesis and trafficking of prion proteins in cultured cells.

@en

Synthesis and trafficking of prion proteins in cultured cells.

@nl

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Molecular Biology of the Cell

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Synthesis and trafficking of prion proteins in cultured cells.

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A J Raeber

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A Taraboulos

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D R Borchelt

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D Serban

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P2860

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications

Cleavage of structural proteins during the assembly of the head of bacteriophage T4

Assembly of asparagine-linked oligosaccharides

Novel proteinaceous infectious particles cause scrapie

Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: evidence for membrane cycling from Golgi to ER

A C-terminal signal prevents secretion of luminal ER proteins

Microtubule-dependent retrograde transport of proteins into the ER in the presence of brefeldin A suggests an ER recycling pathway

Acquisition of protease resistance by prion proteins in scrapie-infected cells does not require asparagine-linked glycosylation

Molecular biology of prion diseases.

A cellular gene encodes scrapie PrP 27-30 protein.

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851-863

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scholarly article

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10.1091/MBC.3.8.851

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8

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Stanley B. Prusiner

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1992-08-01T00:00:00Z

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21798232

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1356522

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Prion protein family

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275644

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