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Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene

Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene

http://www.wikidata.org/entity/Q37373901

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Pathogenic triad in COPD: oxidative stress, protease-antiprotease imbalance, and inflammation Candidate genes for COPD: current evidence and research Systems biology approaches to identify developmental bases for lung diseases Updates on the COPD gene list Biomarkers in chronic obstructive pulmonary disease: confusing or useful?Pulmonary-intestinal cross-talk in mucosal inflammatory disease Genetics of sputum gene expression in chronic obstructive pulmonary disease Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis.Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction Post-GWAS Prioritization Through Data Integration Provides Novel Insights on Chronic Obstructive Pulmonary Disease.Increased iron sequestration in alveolar macrophages in chronic obstructive pulmonary disease Pharmacogenetics of chronic obstructive pulmonary disease: challenges and opportunities.The role of IREB2 and transforming growth factor beta-1 genetic variants in COPD: a replication case-control study.Impact of a functional polymorphism in the PAR-1 gene promoter in COPD and COPD exacerbations Integrative genomics of chronic obstructive pulmonary disease.Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease.Variants in the 15q24/25 locus associate with lung function decline in active smokers.Association of genetic polymorphisms with chronic obstructive pulmonary disease in the Hainan population: a case-control study Opportunities and challenges in the genetics of COPD 2010: an International COPD Genetics Conference report.Genetic determinants of chronic obstructive pulmonary disease in South Indian male smokers.IREB2 and GALC are associated with pulmonary artery enlargement in chronic obstructive pulmonary disease Immunology, genetics and microbiota in the COPD pathophysiology: potential scope for patient stratification.Gene susceptibility identification in a longitudinal study confirms new loci in the development of chronic obstructive pulmonary disease and influences lung function decline.Smoking cessation pharmacogenetics: analysis of varenicline and bupropion in placebo-controlled clinical trials.Nicotinic acetylcholine receptor variants associated with susceptibility to chronic obstructive pulmonary disease: a meta-analysis.Recent advances in the genetic epidemiology and molecular genetics of substance use disorders.A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13.Association of IREB2 and CHRNA3 polymorphisms with airflow obstruction in severe alpha-1 antitrypsin deficiency A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.Identification of FGF7 as a novel susceptibility locus for chronic obstructive pulmonary disease.Susceptibility loci in lung cancer and COPD: association of IREB2 and FAM13A with pulmonary diseases.Association of cigarette smoking and CRP levels with DNA methylation in α-1 antitrypsin deficiency.CHRNA3/5, IREB2, and ADCY2 are associated with severe chronic obstructive pulmonary disease in Poland.The role of iron in pulmonary pathology.Emerging genetics of COPD.Association of IREB2 Gene rs2568494 Polymorphism with Risk of Chronic Obstructive Pulmonary Disease: A Meta-Analysis.Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice.Dissecting direct and indirect genetic effects on chronic obstructive pulmonary disease (COPD) susceptibility.Mammalian iron metabolism and its control by iron regulatory proteins Differential DNA methylation marks and gene comethylation of COPD in African-Americans with COPD exacerbations

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Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene

http://www.wikidata.org/entity/Q37373901

description

article científic

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article scientifique

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bilimsel makale

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scientific article published on October 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Integration of genomic and gen ...... as a COPD susceptibility gene

@en

Integration of genomic and gen ...... as a COPD susceptibility gene.

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type

label

Integration of genomic and gen ...... as a COPD susceptibility gene

@en

Integration of genomic and gen ...... as a COPD susceptibility gene.

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prefLabel

Integration of genomic and gen ...... as a COPD susceptibility gene

@en

Integration of genomic and gen ...... as a COPD susceptibility gene.

@nl

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J.AJHG.2009.09.004

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American Journal of Human Genetics

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Integration of genomic and gen ...... as a COPD susceptibility gene

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Augustine M K Choi

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Christoph Lange

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David A Lomas

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David Sparrow

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Dawn L DeMeo

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Edwin K Silverman

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Gerard J Criner

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Hong P Kim

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John Reilly

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Raphael Bueno

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P2860

Efficiency and power in genetic association studies

Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice

Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1

A variant associated with nicotine dependence, lung cancer and peripheral arterial disease

Epidemiology Standardization Project (American Thoracic Society)

A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease.

A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci.

The SERPINE2 gene is associated with chronic obstructive pulmonary disease.

Preliminary demonstration of an allelic association of the IREB2 gene with Alzheimer's disease

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493-502

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scholarly article

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10.1016/J.AJHG.2009.09.004

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4

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85

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Augusto A Litonjua

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2009-10-01T00:00:00Z

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26866362

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19800047

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chronic obstructive pulmonary disease

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2756547

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