The nuclear receptor PPAR gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity. - Wikidata - wikimedia - TriplyDB

The nuclear receptor PPAR gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity.

The nuclear receptor PPAR gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity.

http://www.wikidata.org/entity/Q37377446

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The role of lipoxin A4 in endometrial biology and endometriosis Recent advances in understanding the molecular mechanisms of the development and function of Th17 cells Regulation of IL-17 in autoimmune diseases by transcriptional factors and microRNAs Innate immunity in the central nervous system Uveitis and gender: the course of uveitis in pregnancy T Helper 17/Regulatory T Cell Balance and Experimental Models of Peritoneal Dialysis-Induced Damage Liver X receptor and peroxisome proliferator-activated receptor as integrators of lipid homeostasis and immunity Modeling the role of peroxisome proliferator-activated receptor γ and microRNA-146 in mucosal immune responses to Clostridium difficile.TH17, TH22 and Treg cells are enriched in the healthy human cecum.Effects of 15-deoxy-delta12,14-prostaglandin J2 (15d-PGJ2) and rosiglitazone on human gammadelta2 T cells.Therapeutic and adverse effects of a non-steroidal glucocorticoid receptor ligand in a mouse model of multiple sclerosis.PPARγ negatively regulates T cell activation to prevent follicular helper T cells and germinal center formation.Abscisic acid ameliorates experimental IBD by downregulating cellular adhesion molecule expression and suppressing immune cell infiltration.Peroxisome proliferator-activated receptor delta limits the expansion of pathogenic Th cells during central nervous system autoimmunity Giardia muris infection in mice is associated with a protective interleukin 17A response and induction of peroxisome proliferator-activated receptor alpha.Lack of PPARγ in myeloid cells confers resistance to Listeria monocytogenes infection.The peroxisome-proliferator activated receptor-γ agonist pioglitazone modulates aberrant T cell responses in systemic lupus erythematosus.Regulation of Immune Responses and Autoimmune Encephalomyelitis by PPARs.Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation Transcriptional and epigenetic regulation of T-helper lineage specification.Systems modeling of molecular mechanisms controlling cytokine-driven CD4+ T cell differentiation and phenotype plasticity.Ciglitazone, a peroxisome proliferator-activated receptor gamma ligand, inhibits proliferation and differentiation of th17 cells.Predictive computational modeling of the mucosal immune responses during Helicobacter pylori infection PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation 15-Deoxy-delta12,14-prostaglandin J2-glycerol ester, a putative metabolite of 2-arachidonyl glycerol, activates peroxisome proliferator activated receptor gamma.Metabolic Control of Th17 Cell Generation and CNS Inflammation Signal transduction pathways and transcriptional regulation in Th17 cell differentiation Peroxisome proliferator-activated receptor gamma is required for CD4+ T cell-mediated lymphopenia-associated autoimmunity.Peroxisome proliferator-activated receptor γ deficiency in T cells accelerates chronic rejection by influencing the differentiation of CD4+ T cells and alternatively activated macrophages Reduced expression of peroxisome proliferator-activated receptor alpha in BAL and blood T cells of non-löfgren's sarcoidosis patients.Regulation and function of innate and adaptive interleukin-17-producing cells Cutting Edge: Dual Function of PPARγ in CD11c+ Cells Ensures Immune Tolerance in the Airways A Sativex(®) -like combination of phytocannabinoids as a disease-modifying therapy in a viral model of multiple sclerosis.Peroxisome proliferator-activated receptor (PPAR)α and -γ regulate IFNγ and IL-17A production by human T cells in a sex-specific way.Fenofibrate inhibited the differentiation of T helper 17 cells in vitro.The role of nuclear receptors in regulation of Th17/Treg biology and its implications for diseases.Clinical and molecular characterization of a severe form of partial lipodystrophy expanding the phenotype of PPARγ deficiency.Identification of novel HIV-1 dependency factors in primary CCR4(+)CCR6(+)Th17 cells via a genome-wide transcriptional approach.Nuclear orphan receptor NR2F6 directly antagonizes NFAT and RORγt binding to the Il17a promoter.Obeticholic acid, a synthetic bile acid agonist of the farnesoid X receptor, attenuates experimental autoimmune encephalomyelitis.

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The nuclear receptor PPAR gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity.

http://www.wikidata.org/entity/Q37377446

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article científic

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article scientifique

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artigo científico

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bilimsel makale

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scientific article published on 08 September 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

The nuclear receptor PPAR gamm ...... d suppresses CNS autoimmunity.

@en

The nuclear receptor PPAR gamm ...... d suppresses CNS autoimmunity.

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type

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The nuclear receptor PPAR gamm ...... d suppresses CNS autoimmunity.

@en

The nuclear receptor PPAR gamm ...... d suppresses CNS autoimmunity.

@nl

prefLabel

The nuclear receptor PPAR gamm ...... d suppresses CNS autoimmunity.

@en

The nuclear receptor PPAR gamm ...... d suppresses CNS autoimmunity.

@nl

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Journal of Experimental Medicine

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The nuclear receptor PPAR gamm ...... d suppresses CNS autoimmunity.

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Birgit Langhans

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Christian Kurts

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Christopher Glass

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Gunter Mayer

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Indra Dani

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Judith Alferink

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Juliane Flossdorf

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Kaoru Saijo

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Luisa Klotz

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Marc Beyer

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P2860

TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function

The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat

Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells

Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor

Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways

Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase

A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

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2079-2089

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scholarly article

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10.1084/JEM.20082771

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10

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206

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Joachim Schultze

Percy A. Knolle

Thomas Klockgether

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2009-09-08T00:00:00Z

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26796709

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19737866

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2757877

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