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Guidelines for the use and interpretation of assays for monitoring autophagyGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)A functional role for the GCC185 golgin in mannose 6-phosphate receptor recycling.A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cellsRUTBC1 protein, a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteinsRab9 GTPase regulates late endosome size and requires effector interaction for its stabilityCholesterol accumulation sequesters Rab9 and disrupts late endosome function in NPC1-deficient cellsULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagyRUTBC2 protein, a Rab9A effector and GTPase-activating protein for Rab36Self-assembly is important for TIP47 function in mannose 6-phosphate receptor transportCharacterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinasePharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy.mito-QC illuminates mitophagy and mitochondrial architecture in vivo.Clues to neuro-degeneration in Niemann-Pick type C disease from global gene expression profilingDistinct autophagosomal-lysosomal fusion mechanism revealed by thapsigargin-induced autophagy arrestCoibamide A induces mTOR-independent autophagy and cell death in human glioblastoma cells.Role of autophagy in histone deacetylase inhibitor-induced apoptotic and nonapoptotic cell death.Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6.Loss of iron triggers PINK1/Parkin-independent mitophagy.The ULK1 complex: sensing nutrient signals for autophagy activation.Autophagosome maturation and lysosomal fusion.MTOR, PIK3C3, and autophagy: Signaling the beginning from the end.Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells.GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signallingLife in lights: Tracking mitochondrial delivery to lysosomes in vivomTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival.Transcription factors NRF2 and HSF1 have opposing functions in autophagy.Determination of VPS34/PIK3C3 Activity in vitro Utilising 32P-γATP.p53 and cell cycle independent dysregulation of autophagy in chronic lymphocytic leukaemiaDetermination of Cellular Phosphatidylinositol-3-phosphate (PI3P) Levels Using a Fluorescently Labelled Selective PI3P Binding Domain (PX).The mammalian ULK1 complex and autophagy initiation.Mammalian mitophagy - from in vitro molecules to in vivo models.ATG5 Promotes Death Signaling in Response to the Cyclic Depsipeptides Coibamide A and Apratoxin A.LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages.Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagyThapsigargin distinguishes membrane fusion in the late stages of endocytosis and autophagyPhosphorylation of Parkin at serine 65 is essential for its activationInvestigating Mitophagy and Mitochondrial Morphology In Vivo Using mito-QC: A Comprehensive GuideGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)The identification and characterisation of autophagy inhibitors from the published kinase inhibitor sets
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Ian G Ganley
@nl
Ian G Ganley
@sl
Ian G. Ganley
@en
Ian G. Ganley
@es
type
label
Ian G Ganley
@nl
Ian G Ganley
@sl
Ian G. Ganley
@en
Ian G. Ganley
@es
prefLabel
Ian G Ganley
@nl
Ian G Ganley
@sl
Ian G. Ganley
@en
Ian G. Ganley
@es
P108
P106
P108
P1153
6507268479
P21
P31
P496
0000-0003-1481-9407