Common CYP2D6 polymorphisms affecting alternative splicing and transcription: long-range haplotypes with two regulatory variants modulate CYP2D6 activity.
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Genome-wide discovery of drug-dependent human liver regulatory elementsIntronic SNP in ESR1 encoding human estrogen receptor alpha is associated with brain ESR1 mRNA isoform expression and behavioral traitsMissing heritability of common diseases and treatments outside the protein-coding exome.G protein-coupled receptor kinase 5 gene polymorphisms are associated with postoperative atrial fibrillation after coronary artery bypass grafting in patients receiving β-blockersFunctional characterization of CYP2D6 enhancer polymorphismsAnalyzing allele specific RNA expression using mixture models.Detection of an endogenous urinary biomarker associated with CYP2D6 activity using global metabolomicsGenetic polymorphisms analysis of CYP2D6 in the Uygur population.In vivo assessment of the metabolic activity of CYP2D6 diplotypes and alleles.CYP3A4 intronic SNP rs35599367 (CYP3A4*22) alters RNA splicing.Uncovering drug-responsive regulatory elements.Regulatory effects of genomic translocations at the human carboxylesterase-1 (CES1) gene locus.Single dose, CYP2D6 genotype-stratified pharmacokinetic study of atomoxetine in children with ADHDCharacterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children.Transcriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell linesPrediction of CYP2D6 phenotype from genotype across world populationsGenomic architecture of pharmacological efficacy and adverse events.Pharmacogenetics of tardive dyskinesia: an updated review of the literature.Transcriptional Regulation of CYP2D6 Expression.The CHRNA5/CHRNA3/CHRNB4 Nicotinic Receptor Regulome: Genomic Architecture, Regulatory Variants, and Clinical Associations.Sequencing the CYP2D6 gene: from variant allele discovery to clinical pharmacogenetic testing.Rapporteur summaries of plenary, symposia, and oral sessions from the XXIIIrd World Congress of Psychiatric Genetics Meeting in Toronto, Canada, 16-20 October 2015.Influence of the rs1080985 Single Nucleotide Polymorphism of the CYP2D6 Gene and APOE Polymorphism on the Response to Donepezil Treatment in Patients with Alzheimer's Disease in China.Improved Prediction of Endoxifen Metabolism by CYP2D6 Genotype in Breast Cancer Patients Treated with Tamoxifen.CYP2D6 and pharmacogenomics: where does future research need to focus? Part 1: technical aspects.Cardiac arrest in a toddler treated with propranolol for infantile Hemangioma: a case report.Impact of CYP2D6 on venlafaxine metabolism in Trinidadian patients with major depressive disorder.The effect of rs5758550 on CYP2D6*2 phenotype and formation of endoxifen in breast cancer patients using tamoxifen.Whole Transcriptome Profiling: An RNA-Seq Primer and Implications for Pharmacogenomics Research.CYP2D6 protein level is the major contributor to inter-individual variability in CYP2D6-mediated drug metabolism in healthy human liver tissue.Ten Years' Experience with the CYP2D6 Activity Score: A Perspective on Future Investigations to Improve Clinical Predictions for Precision Therapeutics.Frequency of CYP2D6 Alleles Including Structural Variants in the United States.Identification of mutations in SLC4A1, GP1BA and HFE in a family with venous thrombosis of unknown cause by next-generation sequencing
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Common CYP2D6 polymorphisms affecting alternative splicing and transcription: long-range haplotypes with two regulatory variants modulate CYP2D6 activity.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 28 August 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Common CYP2D6 polymorphisms af ...... ants modulate CYP2D6 activity.
@en
Common CYP2D6 polymorphisms af ...... ants modulate CYP2D6 activity.
@nl
type
label
Common CYP2D6 polymorphisms af ...... ants modulate CYP2D6 activity.
@en
Common CYP2D6 polymorphisms af ...... ants modulate CYP2D6 activity.
@nl
prefLabel
Common CYP2D6 polymorphisms af ...... ants modulate CYP2D6 activity.
@en
Common CYP2D6 polymorphisms af ...... ants modulate CYP2D6 activity.
@nl
P2093
P2860
P356
P1476
Common CYP2D6 polymorphisms af ...... ants modulate CYP2D6 activity.
@en
P2093
Andrea Gaedigk
Danxin Wang
J Steven Leeder
Xiaochun Sun
P2860
P304
P356
10.1093/HMG/DDT417
P577
2013-08-28T00:00:00Z