The effect of 5-alkyl modification on the biological activity of pyrrolo[2,3-d]pyrimidine containing classical and nonclassical antifolates as inhibitors of dihydrofolate reductase and as antitumor and/or antiopportunistic infection agents.

The effect of 5-alkyl modification on the biological activity of pyrrolo[2,3-d]pyrimidine containing classical and nonclassical antifolates as inhibitors of dihydrofolate reductase and as antitumor and/or antiopportunistic infection agents.

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http://www.wikidata.org/entity/Q37380738
First Three-Dimensional Structure of Toxoplasma gondii Thymidylate Synthase–Dihydrofolate Reductase: Insights for Catalysis, Interdomain Interactions, and Substrate ChannelingOne-pot multicomponent synthesis of diversely substituted 2-aminopyrroles. A short general synthesis of rigidins A, B, C, and D.Review of Experimental Compounds Demonstrating Anti-Toxoplasma Activity.Exploring natural product chemistry and biology with multicomponent reactions. 5. Discovery of a novel tubulin-targeting scaffold derived from the rigidin family of marine alkaloids.Dihydrofolate reductase as a therapeutic target for infectious diseases: opportunities and challenges.Screening for small molecule inhibitors of Toxoplasma gondii.Pyrimethamine-loaded lipid-core nanocapsules to improve drug efficacy for the treatment of toxoplasmosis.Direct C-H sulfenylation of purines and deazapurines.Homology modeling of dihydrofolate reductase from T. gondii bonded to antagonists: molecular docking and molecular dynamics simulations.
P2860

The effect of 5-alkyl modification on the biological activity of pyrrolo[2,3-d]pyrimidine containing classical and nonclassical antifolates as inhibitors of dihydrofolate reductase and as antitumor and/or antiopportunistic infection agents.

Item
http://www.wikidata.org/entity/Q37380738
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 08 July 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The effect of 5-alkyl modifica ...... pportunistic infection agents.
@en
The effect of 5-alkyl modifica ...... pportunistic infection agents.
@nl
type
label
The effect of 5-alkyl modifica ...... pportunistic infection agents.
@en
The effect of 5-alkyl modifica ...... pportunistic infection agents.
@nl
prefLabel
The effect of 5-alkyl modifica ...... pportunistic infection agents.
@en
The effect of 5-alkyl modifica ...... pportunistic infection agents.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P932
P356
P1433
P1476
The effect of 5-alkyl modifica ...... pportunistic infection agents.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P932