The effect of 5-alkyl modification on the biological activity of pyrrolo[2,3-d]pyrimidine containing classical and nonclassical antifolates as inhibitors of dihydrofolate reductase and as antitumor and/or antiopportunistic infection agents.
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First Three-Dimensional Structure of Toxoplasma gondii Thymidylate Synthase–Dihydrofolate Reductase: Insights for Catalysis, Interdomain Interactions, and Substrate ChannelingOne-pot multicomponent synthesis of diversely substituted 2-aminopyrroles. A short general synthesis of rigidins A, B, C, and D.Review of Experimental Compounds Demonstrating Anti-Toxoplasma Activity.Exploring natural product chemistry and biology with multicomponent reactions. 5. Discovery of a novel tubulin-targeting scaffold derived from the rigidin family of marine alkaloids.Dihydrofolate reductase as a therapeutic target for infectious diseases: opportunities and challenges.Screening for small molecule inhibitors of Toxoplasma gondii.Pyrimethamine-loaded lipid-core nanocapsules to improve drug efficacy for the treatment of toxoplasmosis.Direct C-H sulfenylation of purines and deazapurines.Homology modeling of dihydrofolate reductase from T. gondii bonded to antagonists: molecular docking and molecular dynamics simulations.
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The effect of 5-alkyl modification on the biological activity of pyrrolo[2,3-d]pyrimidine containing classical and nonclassical antifolates as inhibitors of dihydrofolate reductase and as antitumor and/or antiopportunistic infection agents.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 08 July 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The effect of 5-alkyl modifica ...... pportunistic infection agents.
@en
The effect of 5-alkyl modifica ...... pportunistic infection agents.
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type
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The effect of 5-alkyl modifica ...... pportunistic infection agents.
@en
The effect of 5-alkyl modifica ...... pportunistic infection agents.
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prefLabel
The effect of 5-alkyl modifica ...... pportunistic infection agents.
@en
The effect of 5-alkyl modifica ...... pportunistic infection agents.
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P2093
P2860
P356
P1476
The effect of 5-alkyl modifica ...... pportunistic infection agents.
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Aleem Gangjee
Hiteshkumar D Jain
Roy L Kisliuk
Sherry F Queener
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P304
P356
10.1021/JM800244V
P407
P577
2008-07-08T00:00:00Z