Phosphoramidon blocks the pressor activity of porcine big endothelin-1-(1-39) in vivo and conversion of big endothelin-1-(1-39) to endothelin-1-(1-21) in vitro.
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Cyclic expression of endothelin-converting enzyme-1 mediates the functional regulation of seminiferous tubule contraction.Pivotal role of mouse mast cell protease 4 in the conversion and pressor properties of Big-endothelin-1.Endothelin peptides: biological activities, cellular signalling and clinical significance.Contractile activity of big endothelin-1 on the human isolated bronchus.The peptidase inhibitor CGS-26303 increases endothelin converting enzyme-1 expression in endothelial cells through accumulation of big endothelin-1Endothelin and erectile dysfunction: a target for pharmacological intervention?Metabolism of endothelin-1 and big endothelin-1 by recombinant neutral endopeptidase EC.3.4.24.11Identification of endothelin-converting enzyme-2 as an autoantigen in autoimmune polyendocrine syndrome type 1.Endothelin-converting enzyme inhibitors for the treatment of subarachnoid hemorrhage-induced vasospasm.The two-step conversion of big endothelin 1 to endothelin 1 and degradation of endothelin 1 by subcellular fractions from human polymorphonuclear leukocytes.Functional and molecular characterization of the endothelin system in retinal arterioles.Positron emission tomography of [18F]-big endothelin-1 reveals renal excretion but tissue-specific conversion to [18F]-endothelin-1 in lung and liverLocalization of rat endothelin-converting enzyme to vascular endothelial cells and some secretory cells.Inhibitors of endothelin.Effects of the neutral endopeptidase inhibitor, SQ 28,603, on regional haemodynamic responses to atrial natriuretic peptide or proendothelin-1 [1-38] in conscious rats.Comparison of haemoconcentration induced by big endothelin-1 and endothelin-1 in mice.Generation by the phosphoramidon-sensitive peptidases, endopeptidase-24.11 and thermolysin, of endothelin-1 and c-terminal fragment from big endothelin-1.Phosphoramidon blocks big-endothelin-1 but not endothelin-1 enhancement of vascular permeability in the rat.Inhibition by phosphoramidon of the regional haemodynamic effects of proendothelin-2 and -3 in conscious rats.The effects of phosphoramidon on the regional haemodynamic responses to human proendothelin [1-38] in conscious rats.Effect of endopeptidase-24.11 inhibition and of atrial natriuretic peptide clearance receptor ligand on the response to rat brain natriuretic peptide in the conscious rat.Phosphoramidon inhibits the generation of endothelin-1 from exogenously applied big endothelin-1 in cultured vascular endothelial cells and smooth muscle cells.Different pharmacological profiles of big-endothelin-3 and big-endothelin-1 in vivo and in vitro.Cross tachyphylaxis to endothelin isopeptide-induced hypotension: a phenomenon not seen with proendothelin.Regional haemodynamic responses to intravenous and intraarterial endothelin-1 and big endothelin-1 in conscious rats.Comparison of the cardiovascular and neural activity of endothelin-1, -2, -3 and respective proendothelins: effects of phosphoramidon and thiorphan.Phosphoramidon-sensitive endothelin-converting enzyme in vascular endothelial cells converts big endothelin-1 and big endothelin-3 to their mature form.Antioxidant activity of plicatin B on cultured human microvascular endothelial cells exposed to H2O2.
P2860
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P2860
Phosphoramidon blocks the pressor activity of porcine big endothelin-1-(1-39) in vivo and conversion of big endothelin-1-(1-39) to endothelin-1-(1-21) in vitro.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on February 1991
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Phosphoramidon blocks the pressor activity of porcine big endothelin-1-
@nl
Phosphoramidon blocks the pres ...... endothelin-1-(1-21) in vitro.
@en
type
label
Phosphoramidon blocks the pressor activity of porcine big endothelin-1-
@nl
Phosphoramidon blocks the pres ...... endothelin-1-(1-21) in vitro.
@en
prefLabel
Phosphoramidon blocks the pressor activity of porcine big endothelin-1-
@nl
Phosphoramidon blocks the pres ...... endothelin-1-(1-21) in vitro.
@en
P2093
P2860
P356
P1476
Phosphoramidon blocks the pres ...... endothelin-1-(1-21) in vitro.
@en
P2093
P2860
P304
P356
10.1073/PNAS.88.3.703
P407
P577
1991-02-01T00:00:00Z