A new animal model for studying Lyme disease spirochetes in a mammalian host-adapted state
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Temporal changes in outer surface proteins A and C of the lyme disease-associated spirochete, Borrelia burgdorferi, during the chain of infection in ticks and miceBorrelia burgdorferi changes its surface antigenic expression in response to host immune responsesA methylated phosphate group and four amide-linked acyl chains in leptospira interrogans lipid A. The membrane anchor of an unusual lipopolysaccharide that activates TLR2Spirochaetal lipoproteins and pathogenesisInitial characterization of the FlgE hook high molecular weight complex of Borrelia burgdorferiStage-specific global alterations in the transcriptomes of Lyme disease spirochetes during tick feeding and following mammalian host adaptation.Microarray-Based Comparative Genomic and Transcriptome Analysis of Borrelia burgdorferiRole of acetyl-phosphate in activation of the Rrp2-RpoN-RpoS pathway in Borrelia burgdorferiAnalysis of promoter elements involved in the transcriptional initiation of RpoS-dependent Borrelia burgdorferi genesStructural modeling and physicochemical characterization provide evidence that P66 forms a β-barrel in the Borrelia burgdorferi outer membrane.Adaptation of Francisella tularensis to the mammalian environment is governed by cues which can be mimicked in vitro.Live imaging reveals a biphasic mode of dissemination of Borrelia burgdorferi within ticks.Cloning and molecular characterization of plasmid-encoded antigens of Borrelia burgdorferi.Borrelia burgdorferi transcriptome in the central nervous system of non-human primates.Examination of the Borrelia burgdorferi transcriptome in Ixodes scapularis during feeding.Identification, characterization, and expression of three new members of the Borrelia burgdorferi Mlp (2.9) lipoprotein gene family.The dynamic proteome of Lyme disease Borrelia.Characterization of a conditional bosR mutant in Borrelia burgdorferi.The BosR regulatory protein of Borrelia burgdorferi interfaces with the RpoS regulatory pathway and modulates both the oxidative stress response and pathogenic properties of the Lyme disease spirochete.Expression and immunological analysis of the plasmid-borne mlp genes of Borrelia burgdorferi strain B31.Comparison of protection in rabbits against host-adapted and cultivated Borrelia burgdorferi following infection-derived immunity or immunization with outer membrane vesicles or outer surface protein A.Staphylococcus aureus serves as an iron source for Pseudomonas aeruginosa during in vivo cocultureDbpA, but not OspA, is expressed by Borrelia burgdorferi during spirochetemia and is a target for protective antibodiesbptA (bbe16) is essential for the persistence of the Lyme disease spirochete, Borrelia burgdorferi, in its natural tick vector.BosR (BB0647) controls the RpoN-RpoS regulatory pathway and virulence expression in Borrelia burgdorferi by a novel DNA-binding mechanism.Comparative analysis and immunological characterization of the Borrelia Bdr protein familyExpression of Borrelia burgdorferi OspC and DbpA is controlled by a RpoN-RpoS regulatory pathway.Cyclic di-GMP is essential for the survival of the lyme disease spirochete in ticksIn vivo gene expression and the adaptive response: from pathogenesis to vaccines and antimicrobials.Borrelia burgdorferi requires glycerol for maximum fitness during the tick phase of the enzootic cycle.Borrelia burgdorferi B31 Erp proteins that are dominant immunoblot antigens of animals infected with isolate B31 are recognized by only a subset of human lyme disease patient sera.The immunoglobulin (IgG) antibody response to OspA and OspB correlates with severe and prolonged Lyme arthritis and the IgG response to P35 correlates with mild and brief arthritis.Molecular and evolutionary analysis of Borrelia burgdorferi 297 circular plasmid-encoded lipoproteins with OspE- and OspF-like leader peptides.Molecular and evolutionary characterization of the cp32/18 family of supercoiled plasmids in Borrelia burgdorferi 297.Stability of Borrelia burgdorferi bdr loci in vitro and in vivo.Homologous and heterologous Borrelia burgdorferi challenge of infection-derived immune rabbits using host-adapted organisms.C-terminal invariable domain of VlsE may not serve as target for protective immune response against Borrelia burgdorferi.VraA (BBI16) protein of Borrelia burgdorferi is a surface-exposed antigen with a repetitive motif that confers partial protection against experimental Lyme borreliosis.Purification and characterization of Borrelia burgdorferi from feeding nymphal ticks (Ixodes scapularis)Regulation of OspE-related, OspF-related, and Elp lipoproteins of Borrelia burgdorferi strain 297 by mammalian host-specific signals
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A new animal model for studying Lyme disease spirochetes in a mammalian host-adapted state
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on May 1998
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A new animal model for studyin ...... a mammalian host-adapted state
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A new animal model for studyin ...... mammalian host-adapted state.
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type
label
A new animal model for studyin ...... a mammalian host-adapted state
@en
A new animal model for studyin ...... mammalian host-adapted state.
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prefLabel
A new animal model for studyin ...... a mammalian host-adapted state
@en
A new animal model for studyin ...... mammalian host-adapted state.
@nl
P2093
P2860
P356
P1476
A new animal model for studyin ...... a mammalian host-adapted state
@en
P2093
J D Radolf
K W Bourell
M J Caimano
M V Norgard
P2860
P304
P356
10.1172/JCI2325
P407
P577
1998-05-01T00:00:00Z