Identification of protein targets of 4-hydroxynonenal using click chemistry for ex vivo biotinylation of azido and alkynyl derivatives.
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4-Hydroxy-nonenal-A Bioactive Lipid Peroxidation ProductEndogenous Generation and Signaling Actions of Omega-3 Fatty Acid Electrophilic DerivativesProtein lipoxidation: Detection strategies and challengesRedox modification of proteins as essential mediators of CNS autophagy and mitophagy.Chemical proteomics approaches for identifying the cellular targets of natural productsThe electrophile responsive proteome: integrating proteomics and lipidomics with cellular functionGeneration and biological activities of oxidized phospholipidsProtein adducts of aldehydic lipid peroxidation products identification and characterization of protein adducts using an aldehyde/keto-reactive probe in combination with mass spectrometryTransduction of redox signaling by electrophile-protein reactionsRedox proteomics in selected neurodegenerative disorders: from its infancy to future applications.Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes.Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe.Selective gamma-ketoaldehyde scavengers protect Nav1.5 from oxidant-induced inactivation.Site-specific protein adducts of 4-hydroxy-2(E)-nonenal in human THP-1 monocytic cells: protein carbonylation is diminished by ascorbic acid.Comparative methods for analysis of protein covalent modification by electrophilic quinoids formed from xenobiotics.Redox regulation of antioxidants, autophagy, and the response to stress: implications for electrophile therapeutics.Oxysterols from free radical chain oxidation of 7-dehydrocholesterol: product and mechanistic studies.Systems analysis of protein modification and cellular responses induced by electrophile stress.A Click Chemistry Approach to Identify Protein Targets of Cancer Chemopreventive Phenethyl Isothiocyanate.Proteins modified by the lipid peroxidation aldehyde 9,12-dioxo-10(E)-dodecenoic acid in MCF7 breast cancer cells.ω-Alkynyl lipid surrogates for polyunsaturated fatty acids: free radical and enzymatic oxidations.Differential metabolism of 4-hydroxynonenal in liver, lung and brain of mice and rats.Small molecule activators of the heat shock response: chemical properties, molecular targets, and therapeutic promise.Assay of protein and peptide adducts of cholesterol ozonolysis products by hydrophobic and click enrichment methodsChemical biology applied to the study of bacterial pathogens.Structure-activity analysis of diffusible lipid electrophiles associated with phospholipid peroxidation: 4-hydroxynonenal and 4-oxononenal analogues.Probing lipid-protein adduction with alkynyl surrogates: application to Smith-Lemli-Opitz syndrome.The lipid peroxidation product 4-hydroxy-2-nonenal: Advances in chemistry and analysisSelective enrichment and identification of azide-tagged cross-linked peptides using chemical ligation and mass spectrometry.Detection and quantification of protein adduction by electrophilic fatty acids: mitochondrial generation of fatty acid nitroalkene derivatives.Protein-selective capture to analyze electrophile adduction of hsp90 by 4-hydroxynonenal.Relationship of electrophilic stress to agingExploring the biology of lipid peroxidation-derived protein carbonylation.Site-specific proteomic analysis of lipoxidation adducts in cardiac mitochondria reveals chemical diversity of 2-alkenal adductionSite-specific, intramolecular cross-linking of Pin1 active site residues by the lipid electrophile 4-oxo-2-nonenal.Cell signalling by reactive lipid species: new concepts and molecular mechanisms.Formation and signaling actions of electrophilic lipidsInflammation and cancer: chemical approaches to mechanisms, imaging, and treatment.Protein modification by oxidized phospholipids and hydrolytically released lipid electrophiles: Investigating cellular responses.Metabolic impact of 4-hydroxynonenal on macrophage-like RAW 264.7 function and activation.
P2860
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P2860
Identification of protein targets of 4-hydroxynonenal using click chemistry for ex vivo biotinylation of azido and alkynyl derivatives.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 31 January 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
Identification of protein targ ...... azido and alkynyl derivatives.
@en
Identification of protein targ ...... azido and alkynyl derivatives.
@nl
type
label
Identification of protein targ ...... azido and alkynyl derivatives.
@en
Identification of protein targ ...... azido and alkynyl derivatives.
@nl
prefLabel
Identification of protein targ ...... azido and alkynyl derivatives.
@en
Identification of protein targ ...... azido and alkynyl derivatives.
@nl
P2093
P2860
P356
P1476
Identification of protein targ ...... azido and alkynyl derivatives
@en
P2093
Aaron T Jacobs
Andrew Vila
Keri A Tallman
Lawrence J Marnett
Ned A Porter
P2860
P304
P356
10.1021/TX700347W
P577
2008-01-31T00:00:00Z