about
Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumorsTranslation initiation factor eIF4F modifies the dexamethasone response in multiple myelomaDevelopment of siRNA payloads to target KRAS-mutant cancer.Profiling of engineering hotspots identifies an allosteric CRISPR-Cas9 switchAn optimized microRNA backbone for effective single-copy RNAi.Functional identification of optimized RNAi triggers using a massively parallel sensor assay.An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance.MYC Drives Pten/Trp53-Deficient Proliferation and Metastasis due to IL6 Secretion and AKT Suppression via PHLPP2.Tiling genomes of pathogenic viruses identifies potent antiviral shRNAs and reveals a role for secondary structure in shRNA efficacy.HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase.Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi.Prediction of potent shRNAs with a sequential classification algorithm.A pipeline for the generation of shRNA transgenic miceStable RNA interference rules for silencing.A computational algorithm to predict shRNA potency.Cornerstones of CRISPR-Cas in drug discovery and therapy.Differential Effector Engagement by Oncogenic KRAS.Extension of the crRNA enhances Cpf1 gene editing in vitro and in vivoSystematic discovery of natural CRISPR-Cas12a inhibitorsMAP kinase and autophagy pathways cooperate to maintain RAS mutant cancer cell survivalControlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAsStructural basis for AcrVA4 inhibition of specific CRISPR-Cas12aPotent CRISPR-Cas9 inhibitors from Staphylococcus genomesCRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome ModificationDisruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent MannerCircularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editorsAuthor Correction: Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors
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description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Christof Fellmann
@ast
Christof Fellmann
@en
Christof Fellmann
@es
Christof Fellmann
@nl
Christof Fellmann
@sl
type
label
Christof Fellmann
@ast
Christof Fellmann
@en
Christof Fellmann
@es
Christof Fellmann
@nl
Christof Fellmann
@sl
prefLabel
Christof Fellmann
@ast
Christof Fellmann
@en
Christof Fellmann
@es
Christof Fellmann
@nl
Christof Fellmann
@sl
P106
P21
P31
P496
0000-0002-9545-5723