about
Frailty in mouse ageing: A conceptual approachNeuroinflammation and Depression: Microglia Activation, Extracellular Microvesicles and microRNA DysregulationMicroglia centered pathogenesis in ALS: insights in cell interconnectivityBile acid patterns in meconium are influenced by cholestasis of pregnancy and not altered by ursodeoxycholic acid treatmentRole of multidrug resistance-associated protein 1 expression in the in vitro susceptibility of rat nerve cell to unconjugated bilirubinAstrocyte reactivity to unconjugated bilirubin requires TNF-α and IL-1β receptor signaling pathwaysRat cerebellar slice cultures exposed to bilirubin evidence reactive gliosis, excitotoxicity and impaired myelinogenesis that is prevented by AMPA and TNF-α inhibitorsBilirubin induces apoptosis via the mitochondrial pathway in developing rat brain neurons.Blood-brain barrier and bilirubin: clinical aspects and experimental data.Bilirubin-induced apoptosis in cultured rat neural cells is aggravated by chenodeoxycholic acid but prevented by ursodeoxycholic acid.Automated analysis of NeuronJ tracing data.Microglia change from a reactive to an age-like phenotype with the time in cultureN-methyl-aspartate receptor and neuronal nitric oxide synthase activation mediate bilirubin-induced neurotoxicityExposure to lipopolysaccharide and/or unconjugated bilirubin impair the integrity and function of brain microvascular endothelial cellsEstablishment of primary cultures of human brain microvascular endothelial cells to provide an in vitro cellular model of the blood-brain barrier.Neuroprotective effects of erythropoietin pretreatment in a rodent model of transient middle cerebral artery occlusion.Hydrophilic bile acids protect human blood-brain barrier endothelial cells from disruption by unconjugated bilirubin: an in vitro studySystemic inflammation in early neonatal mice induces transient and lasting neurodegenerative effects.Molecular basis of bilirubin-induced neurotoxicity.The evolving landscape of neurotoxicity by unconjugated bilirubin: role of glial cells and inflammation.Glio-vascular changes during ageing in wild-type and Alzheimer's disease-like APP/PS1 mice.Reduced Myelination and Increased Glia Reactivity Resulting from Severe Neonatal HyperbilirubinemiaBilirubin toxicity to human erythrocytes: a review.Biological risks for neurological abnormalities associated with hyperbilirubinemia.Contribution of inflammatory processes to nerve cell toxicity by bilirubin and efficacy of potential therapeutic agents.Looking at the blood-brain barrier: molecular anatomy and possible investigation approaches.Bilirubin injury to neurons and glial cells: new players, novel targets, and newer insights.A look at tricellulin and its role in tight junction formation and maintenance.Neurovascular unit: a focus on pericytes.Bilirubin-induced neural impairment: a special focus on myelination, age-related windows of susceptibility and associated co-morbidities.Oligodendrocyte Development and Myelination in Neurodevelopment: Molecular Mechanisms in Health and Disease.Dipeptidyl Vinyl Sulfone as a Novel Chemical Tool to Inhibit HMGB1/NLRP3-Inflammasome and Inflamma-miRs in Aβ-Mediated Microglial Inflammation.Exosomes from NSC-34 Cells Transfected with hSOD1-G93A Are Enriched in miR-124 and Drive Alterations in Microglia Phenotype.Targeting Gliomas: Can a New Alkylating Hybrid Compound Make a Difference?Exploring New Inflammatory Biomarkers and Pathways during LPS-Induced M1 Polarization.Tricellulin expression in brain endothelial and neural cells.Beneficial effect of ursodeoxycholic acid on alterations induced by cholestasis of pregnancy in bile acid transport across the human placenta.Elevated levels of bilirubin and long-term exposure impair human brain microvascular endothelial cell integrity.Polyphenols journey through blood-brain barrier towards neuronal protection.Potential for brain accessibility and analysis of stability of selected flavonoids in relation to neuroprotection in vitro.
P50
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P50
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հետազոտող
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D Brites
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P1053
M-8293-2013
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P569
2000-01-01T00:00:00Z