Biomedical application of orexin/hypocretin receptor ligands in neuroscience.
about
Orexin receptors: pharmacology and therapeutic opportunitiesDynein light chain Tctex-type 1 modulates orexin signaling through its interaction with orexin 1 receptorSubstituted tetrahydroisoquinolines as selective antagonists for the orexin 1 receptor.Rapid identification of orexin receptor binding ligands using cell-based screening accelerated with magnetic beadsSuvorexant for the treatment of insomnia.Diaryl urea analogues of SB-334867 as orexin-1 receptor antagonists.Effect of 1-substitution on tetrahydroisoquinolines as selective antagonists for the orexin-1 receptorHigh-threshold Ca2+ channels behind gamma band activity in the pedunculopontine nucleus (PPN).The orexin receptor OX(1)R in colon cancer: a promising therapeutic target and a new paradigm in G protein-coupled receptor signalling through ITIMs.Disubstituted piperidines as potent orexin (hypocretin) receptor antagonists.The role of orexins/hypocretins in alcohol use and abuse: an appetitive-reward relationship.Chemistry and biology of multicomponent reactions.Intracellular mechanisms modulating gamma band activity in the pedunculopontine nucleus (PPN).Truncated Orexin Peptides: Structure-Activity Relationship StudiesOrexin receptor antagonists: a review of promising compounds patented since 2006.Pharmacotherapy of insomnia.Orexin receptor antagonists.Orexin receptor antagonists--a patent review (2010 to August 2014).Small-molecule antagonists of the orexin receptors.Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Structure-activity relationship, biological, and pharmacological characterization of the proline sulfonamide ACT-462206: a potent, brain-penetrant dual orexin 1/orexin 2 receptor antagonist.Orexin receptor antagonism, a new sleep-promoting paradigm: an ascending single-dose study with almorexant.Polycyclic indole alkaloid-type compounds by MCR.Treatment and prevention of various therapeutic conditions using OX receptor antagonistic activity (WO2012081692).Synthesis and Evaluation of Orexin-1 Receptor Antagonists with Improved Solubility and CNS Permeability.Discovery of Highly Potent Dual Orexin Receptor Antagonists via a Scaffold-Hopping Approach.Frontiers in Medicinal Chemistry 2009--a summary of the meeting at Heidelberg University.
P2860
Q24597418-0EBAE919-9A83-4B88-9064-35D692175B4FQ28505089-A34DF08B-B89E-4C6B-AB20-56C2EFDC441FQ30558573-17D18940-CFFF-4182-ABC0-0B8D63DEE336Q33519952-492C2068-47B1-4A59-A1A6-BEBFFBB2569BQ34443676-B9DFBBF7-FE34-430E-9B79-61B68962AFA2Q34899602-0B9229E2-CE75-427A-9A01-7FE1DCFD9F8AQ35450376-2F148B46-9281-4E83-ADA7-E575A86F3639Q35877571-63A44D20-7A08-444A-B7A4-4D4FDAA2AF28Q36025321-D6382130-5A83-4645-8579-70B71A5EA9EFQ36059941-B93A3097-482E-4D16-9B38-E8DE4B8D283FQ36417619-367647A3-05A5-426D-9AF5-14FEE22E4BEFQ37017587-C4440378-4E27-4474-BA3E-E0AAA0FE3B19Q37043339-72BF94DD-4557-42F2-9474-A2B33994DA7EQ37683433-CD590216-7EB2-498B-9ABC-D14D661BDECAQ37697791-360262FB-28E6-4082-95A1-D871E8DEE025Q38009370-E41F62B5-3CF2-4445-AD13-E3C394A5C9F0Q38162930-95DEFA8D-3623-42CE-8CE1-C4C42AD232AAQ38269308-EB4BE80D-E8C1-440B-982F-659BD0CB2DFBQ38285705-5D358CAA-23AC-48ED-92BB-B2B1F87678C0Q40290586-F7ABE819-9190-45E8-9B71-A7C08A3A7DA6Q42704416-61C38FFF-1CFB-421C-9676-815A302DE970Q43106547-C2FCC6BE-D2B9-445E-BA40-221452B0337FQ43189174-D7E3B169-E32F-4E4F-AB90-045F1162FE97Q45384050-D0F72AB5-4D54-42E9-9FEA-6F24703458C5Q47307899-7BEA9F81-2FC4-4E73-99B8-BE997DAFCFAFQ47839193-0300DFDC-EC0B-4C63-88B9-59FBE2B1DBFDQ51829072-F620D83C-5D57-401A-9EB3-2AABB5D6E529
P2860
Biomedical application of orexin/hypocretin receptor ligands in neuroscience.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on February 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Biomedical application of orexin/hypocretin receptor ligands in neuroscience.
@en
Biomedical application of orexin/hypocretin receptor ligands in neuroscience.
@nl
type
label
Biomedical application of orexin/hypocretin receptor ligands in neuroscience.
@en
Biomedical application of orexin/hypocretin receptor ligands in neuroscience.
@nl
prefLabel
Biomedical application of orexin/hypocretin receptor ligands in neuroscience.
@en
Biomedical application of orexin/hypocretin receptor ligands in neuroscience.
@nl
P2093
P356
P1476
Biomedical application of orexin/hypocretin receptor ligands in neuroscience.
@en
P2093
Catherine Brisbare-Roch
Christoph Boss
Francois Jenck
P304
P356
10.1021/JM801296D
P407
P577
2009-02-01T00:00:00Z