Location of inhibitors bound to group IVA phospholipase A2 determined by molecular dynamics and deuterium exchange mass spectrometry.
about
Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic interventionInsertion of the Ca²⁺-independent phospholipase A₂ into a phospholipid bilayer via coarse-grained and atomistic molecular dynamics simulationsType 1 and Type 2 scenarios in hydrogen exchange mass spectrometry studies on protein-ligand complexes.Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells.Development of Potent and Selective Inhibitors for Group VIA Calcium-Independent Phospholipase A2 Guided by Molecular Dynamics and Structure-Activity Relationships.Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2.Mechanism of intracellular cAMP sensor Epac2 activation: cAMP-induced conformational changes identified by amide hydrogen/deuterium exchange mass spectrometry (DXMS).Inhibition of secreted phospholipases A₂ by 2-oxoamides based on α-amino acids: Synthesis, in vitro evaluation and molecular docking calculations.Membranes serve as allosteric activators of phospholipase A2, enabling it to extract, bind, and hydrolyze phospholipid substratesBinding conformation of 2-oxoamide inhibitors to group IVA cytosolic phospholipase A2 determined by molecular docking combined with molecular dynamics.Phospholipase A2IVα regulates phagocytosis independent of its enzymatic activityApplications of mass spectrometry to lipids and membranesStructural basis of specific interactions of Lp-PLA2 with HDL revealed by hydrogen deuterium exchange mass spectrometryUsing hydrogen/deuterium exchange mass spectrometry to define the specific interactions of the phospholipase A2 superfamily with lipid substrates, inhibitors, and membranes.Membrane and inhibitor interactions of intracellular phospholipases A2.Liberating Chiral Lipid Mediators, Inflammatory Enzymes, and LIPID MAPS from Biological Grease.Phospholipase A2 inhibitors as potential therapeutic agents for the treatment of inflammatory diseases.Phospholipase A2 inhibitors for the treatment of inflammatory diseases: a patent review (2010--present).Analyses of Calcium-Independent Phospholipase A2beta (iPLA2β) in Biological Systems.Computer-aided drug design guided by hydrogen/deuterium exchange mass spectrometry: A powerful combination for the development of potent and selective inhibitors of Group VIA calcium-independent phospholipase A2.Lipoprotein-associated phospholipase A(2) interacts with phospholipid vesicles via a surface-disposed hydrophobic α-helix.2-Oxoesters: A Novel Class of Potent and Selective Inhibitors of Cytosolic Group IVA Phospholipase A2.Fluoroketone inhibition of Ca(2+)-independent phospholipase A2 through binding pocket association defined by hydrogen/deuterium exchange and molecular dynamics.A New Generation of Arachidonic Acid Analogues as Potential Neurological Agent Targeting Cytosolic Phospholipase A2.Hydrogen-deuterium exchange reveals long-range dynamical allostery in soybean lipoxygenase.An overview of hydrogen deuterium exchange mass spectrometry (HDX-MS) in drug discovery.Membrane Allostery and Unique Hydrophobic Sites Promote Enzyme Substrate Specificity.Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
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P2860
Location of inhibitors bound to group IVA phospholipase A2 determined by molecular dynamics and deuterium exchange mass spectrometry.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on June 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Location of inhibitors bound t ...... um exchange mass spectrometry.
@en
Location of inhibitors bound t ...... um exchange mass spectrometry.
@nl
type
label
Location of inhibitors bound t ...... um exchange mass spectrometry.
@en
Location of inhibitors bound t ...... um exchange mass spectrometry.
@nl
prefLabel
Location of inhibitors bound t ...... um exchange mass spectrometry.
@en
Location of inhibitors bound t ...... um exchange mass spectrometry.
@nl
P2093
P2860
P50
P356
P1476
Location of inhibitors bound t ...... um exchange mass spectrometry.
@en
P2093
Alemayehu A Gorfe
Arneh Babakhani
George Kokotos
Virgil L Woods
P2860
P304
P356
10.1021/JA900098Y
P407
P577
2009-06-01T00:00:00Z