A novel hypoxia-selective epigenetic agent RRx-001 triggers apoptosis and overcomes drug resistance in multiple myeloma cells.
about
RRx-001: a systemically non-toxic M2-to-M1 macrophage stimulating and prosensitizing agent in Phase II clinical trials.Antineoplastic effects of CPPTL via the ROS/JNK pathway in acute myeloid leukemia.A Partial Response to Reintroduced Chemotherapy in a Resistant Small Cell Lung Cancer Patient After Priming with RRx-001.Shikonin induces mitochondria-mediated apoptosis and enhances chemotherapeutic sensitivity of gastric cancer through reactive oxygen species.DNA methylation profiles in cancer diagnosis and therapeutics.Role of epigenetics-microRNA axis in drug resistance of multiple myeloma.The immunomodulatory anticancer agent, RRx-001, induces an interferon response through epigenetic induction of viral mimicry.Dual-utility NLS drives RNF169-dependent DNA damage responses.Proteasome-associated deubiquitinases and cancer.Blockade of Deubiquitylating Enzyme USP1 Inhibits DNA Repair and Triggers Apoptosis in Multiple Myeloma Cells.Oxidative stress response induced by chemotherapy in leukemia treatment.
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A novel hypoxia-selective epigenetic agent RRx-001 triggers apoptosis and overcomes drug resistance in multiple myeloma cells.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 27 April 2016
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A novel hypoxia-selective epig ...... nce in multiple myeloma cells.
@en
A novel hypoxia-selective epig ...... nce in multiple myeloma cells.
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type
label
A novel hypoxia-selective epig ...... nce in multiple myeloma cells.
@en
A novel hypoxia-selective epig ...... nce in multiple myeloma cells.
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prefLabel
A novel hypoxia-selective epig ...... nce in multiple myeloma cells.
@en
A novel hypoxia-selective epig ...... nce in multiple myeloma cells.
@nl
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A novel hypoxia-selective epig ...... nce in multiple myeloma cells.
@en
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D Sharma Das
J Scicinski
K C Anderson
P Richardson
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P2888
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10.1038/LEU.2016.96
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2016-04-27T00:00:00Z
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1016929354