RNA dimerization promotes PKR dimerization and activation.
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Molecular mechanisms of long noncoding RNAs on gastric cancerRegulation of PKR by HCV IRES RNA: importance of domain II and NS5ALINE-1 retrotransposons: mediators of somatic variation in neuronal genomes?Analysis of PKR activation using analytical ultracentrifugationHigh affinity, dsRNA binding by disconnected interacting protein 1Native tertiary structure and nucleoside modifications suppress tRNA's intrinsic ability to activate the innate immune sensor PKR.Regulation of innate immunity through RNA structure and the protein kinase PKR.RNA helical imperfections regulate activation of the protein kinase PKR: effects of bulge position, size, and geometry.The use of analytical sedimentation velocity to extract thermodynamic linkage.Heparin activates PKR by inducing dimerization.Mechanistic Analysis of Activation of the Innate Immune Sensor PKR by Bacterial RNAMechanistic characterization of the 5'-triphosphate-dependent activation of PKR: lack of 5'-end nucleobase specificity, evidence for a distinct triphosphate binding site, and a critical role for the dsRBD.The Regulatory and Kinase Domains but Not the Interdomain Linker Determine Human Double-stranded RNA-activated Kinase (PKR) Sensitivity to Inhibition by Viral Non-coding RNAsProtein kinase PKR amplification of interferon β induction occurs through initiation factor eIF-2α-mediated translational controlActivation of PKR by RNA misfolding: HDV ribozyme dimers activate PKR.Exosomes from HIV-1-infected Cells Stimulate Production of Pro-inflammatory Cytokines through Trans-activating Response (TAR) RNASpecificity of the double-stranded RNA-binding domain from the RNA-activated protein kinase PKR for double-stranded RNA: insights from thermodynamics and small-angle X-ray scattering.Movements of HIV-1 genomic RNA-APOBEC3F complexes and PKR reveal cytoplasmic and nuclear PKR defenses and HIV-1 evasion strategies.Bacterial Riboswitches and Ribozymes Potently Activate the Human Innate Immune Sensor PKRActivation of PKR by short stem-loop RNAs containing single-stranded arms.Discriminating Self and Non-Self by RNA: Roles for RNA Structure, Misfolding, and Modification in Regulating the Innate Immune Sensor PKRActivation of the Antiviral Kinase PKR and Viral Countermeasures.Analysis of PKR-RNA interactions by sedimentation velocityThe cellular TAR RNA binding protein, TRBP, promotes HIV-1 replication primarily by inhibiting the activation of double-stranded RNA-dependent kinase PKR.Mechanism of Protein Kinase R Inhibition by Human Cytomegalovirus pTRS1.Translation inhibition and stress granules in the antiviral immune response.Human noncoding RNA 886 (nc886) adopts two structurally distinct conformers that are functionally opposing regulators of PKR.Regulation of PKR by RNA: formation of active and inactive dimers.Interaction of PKR with single-stranded RNAMagnesium-dependent interaction of PKR with adenovirus VAI.Recognition of viral RNA stem-loops by the tandem double-stranded RNA binding domains of PKR.Contribution of the two dsRBM motifs to the double-stranded RNA binding and protein interactions of PACT.Increased interaction between PACT molecules in response to stress signals is required for PKR activation.Long non-coding RNA HOTAIR promotes UVB-induced apoptosis and inflammatory injury by up-regulation of PKR in keratinocytes.APOL1 risk allele RNA contributes to renal toxicity by activating protein kinase R
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P2860
RNA dimerization promotes PKR dimerization and activation.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 13 May 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
RNA dimerization promotes PKR dimerization and activation.
@en
RNA dimerization promotes PKR dimerization and activation.
@nl
type
label
RNA dimerization promotes PKR dimerization and activation.
@en
RNA dimerization promotes PKR dimerization and activation.
@nl
prefLabel
RNA dimerization promotes PKR dimerization and activation.
@en
RNA dimerization promotes PKR dimerization and activation.
@nl
P2093
P2860
P1476
RNA dimerization promotes PKR dimerization and activation.
@en
P2093
Amy Diegelman-Parente
C Jason Wong
James L Cole
Jeffrey Lary
Laurie A Heinicke
Philip C Bevilacqua
Subba Rao Nallagatla
Xiaofeng Zheng
P2860
P304
P356
10.1016/J.JMB.2009.05.005
P407
P577
2009-05-13T00:00:00Z