The proteasome inhibitor epoxomicin has potent Plasmodium falciparum gametocytocidal activity. - Wikidata - wikimedia - TriplyDB

The proteasome inhibitor epoxomicin has potent Plasmodium falciparum gametocytocidal activity.

The proteasome inhibitor epoxomicin has potent Plasmodium falciparum gametocytocidal activity.

http://www.wikidata.org/entity/Q37392803

about

Computational Approaches for the Discovery of Human Proteasome Inhibitors: An Overview Thiostrepton and derivatives exhibit antimalarial and gametocytocidal activity by dually targeting parasite proteasome and apicoplast Activity of clinically relevant antimalarial drugs on Plasmodium falciparum mature gametocytes in an ATP bioluminescence "transmission blocking" assay Blocking Plasmodium falciparum development via dual inhibition of hemoglobin degradation and the ubiquitin proteasome system by MG132 A flow cytometry-based quantitative drug sensitivity assay for all Plasmodium falciparum gametocyte stages Characterization of the 26S proteasome network in Plasmodium falciparum Genetic basis for the biosynthesis of the pharmaceutically important class of epoxyketone proteasome inhibitors.Malaria gametocytogenesis.Identification of potent and selective non-covalent inhibitors of the Plasmodium falciparum proteasome.Validation of the proteasome as a therapeutic target in Plasmodium using an epoxyketone inhibitor with parasite-specific toxicity Stage-specific expression of protease genes in the apicomplexan parasite, Eimeria tenella A quantitative high throughput assay for identifying gametocytocidal compounds A malaria gametocytocidal assay using oxidoreduction indicator, alamarBlue Antiapicoplast and gametocytocidal screening to identify the mechanisms of action of compounds within the malaria box.Potent Plasmodium falciparum gametocytocidal activity of diaminonaphthoquinones, lead antimalarial chemotypes identified in an antimalarial compound screen.Synthesis and evaluation of the antiplasmodial activity of tryptanthrin derivatives.An integrative analysis of small molecule transcriptional responses in the human malaria parasite Plasmodium falciparum Current advances in detection and treatment of babesiosis High-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission.Structure- and function-based design of Plasmodium-selective proteasome inhibitors Maduramicin Rapidly Eliminates Malaria Parasites and Potentiates the Gametocytocidal Activity of the Pyrazoleamide PA21A050.Broad-spectrum antimalarial activity of peptido sulfonyl fluorides, a new class of proteasome inhibitors.Plasmodium dipeptidyl aminopeptidases as malaria transmission-blocking drug targets.Threonine peptidases as drug targets against malaria.Proteases as regulators of pathogenesis: examples from the Apicomplexa.Proteasome inhibitors: an expanding army attacking a unique target.The proteasome of malaria parasites: A multi-stage drug target for chemotherapeutic intervention?Strategic use of antimalarial drugs that block falciparum malaria parasite transmission to mosquitoes to achieve local malaria elimination.Multicolor bioluminescence boosts malaria research: quantitative dual-color assay and single-cell imaging in Plasmodium falciparum parasites Protein Degradation Systems as Antimalarial Therapeutic Targets.Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity.The Proteasome in Modern Drug Discovery: Second Life of a Highly Valuable Drug Target A Plasmodium falciparum screening assay for anti-gametocyte drugs based on parasite lactate dehydrogenase detection.The biology of sexual development of Plasmodium: the design and implementation of transmission-blocking strategies.Blocking Plasmodium falciparum Malaria Transmission with Drugs: The Gametocytocidal and Sporontocidal Properties of Current and Prospective Antimalarials.Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance

P2860

Q26738752-E2578E34-0B80-4F90-A793-EA56C6E84BB0 Q27973422-A8A92CB4-10F6-4493-B95E-421EA160712F Q28482292-02617438-1D6A-4788-8B14-3793B622E6BB Q28536452-75DDCE3E-397D-4FC4-8375-24E4D42C69E4 Q28537902-F88AC78B-34C1-4916-BD01-580972FBD76B Q30043793-3C898CF5-739C-43EF-9CD0-61DF57CC41EE Q33696772-0FA0018A-24E1-4A10-96DE-CFF79CC04824 Q33894262-00A1A23F-75C6-45AF-9EA9-41CA58C3F781 Q34282526-076CFEE3-3A99-4F96-B994-12E5AD58A9CB Q34473136-8CAF88AC-981F-469D-813C-108BD4BE312C Q34502472-98033F5F-10BA-4EAF-95F8-131D2A2D8AB4 Q34605248-C1D38927-2CE9-458F-AAA6-72DC8170DF97 Q34786064-B79E0DD7-7816-4F54-92F5-6303BD4DDF1F Q35046030-3FD39E22-0A22-4330-9E87-FF18713D64A6 Q35076804-5FA91A17-67F2-4617-A1DB-4C50250684A3 Q35563920-A6EDAE5C-94BB-43F8-A740-C11EBC93BBEB Q35861261-88D0F477-FA3C-444D-AB60-49A8BB6FA6F6 Q35969816-D2188F34-8D8F-4074-9065-D95E4309F6CA Q36492518-95052607-DEC7-4B1E-A875-413EDDD64B32 Q36584903-4D149239-E807-47C7-AA1E-A7EF558EBCDA Q36644774-6B3FA256-CB18-4855-BD96-C35D781B0A58 Q37036656-36186491-29C7-42D0-9222-63391E4B84AA Q37263718-827B953B-3AC7-41B3-B662-9D03B6DD05B2 Q37833642-76EE9086-3EB1-406D-9F23-EC19B257E0D3 Q37891227-93DC1314-0400-4BAE-8030-B9B0B74E28F7 Q37979388-AFD8FCDD-7BA2-4B47-B65E-341FCCA15C83 Q38188569-51910E06-3792-41DF-A444-CAD60440B78F Q38245842-0ACE97B2-6021-4FD4-A3C8-0E64521AE058 Q38968045-977B2589-0B05-4F11-B5E8-2688F93E7175 Q39422863-66F0A488-6046-405E-B975-5A27F0A9E760 Q40139788-C29289EF-CE48-4710-832E-07226ED1A921 Q41519882-7D0E62BB-E9B5-44FA-ABAB-5D3D80A2FCE1 Q41925849-6B709D7A-9E36-4CD3-B0EC-044DD55B8C3C Q42562371-54AF06E6-AABB-4C58-B8BC-03E36B07A30D Q47169530-C2F10F88-BEC3-44FF-9BC4-D2EF3A32EC8B Q56362409-67EC525C-80A2-45C5-801D-6D78396812EA

P2860

The proteasome inhibitor epoxomicin has potent Plasmodium falciparum gametocytocidal activity.

http://www.wikidata.org/entity/Q37392803

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 03 August 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

The proteasome inhibitor epoxo ...... arum gametocytocidal activity.

@en

The proteasome inhibitor epoxo ...... arum gametocytocidal activity.

@nl

type

label

The proteasome inhibitor epoxo ...... arum gametocytocidal activity.

@en

The proteasome inhibitor epoxo ...... arum gametocytocidal activity.

@nl

prefLabel

The proteasome inhibitor epoxo ...... arum gametocytocidal activity.

@en

The proteasome inhibitor epoxo ...... arum gametocytocidal activity.

@nl

P1433

Q37392803-196D36EC-5E19-4ECD-BA84-27040C9E89B9

P1476

Q37392803-94D381BB-BBBC-4289-A97E-F4D943677A86

P2093

Q37392803-290D8378-0B37-43E8-8B23-36C5CA5BD8A9

Q37392803-635DF38C-2C73-409C-9AFE-B295CB1A9CD6

Q37392803-69B6F5AC-4DF0-4186-AA71-84332BC58732

Q37392803-C9E89F4D-F6D9-40D2-8FC0-CFD47C7B7636

P2860

Q37392803-08F1CFE7-6CBD-4A2F-8986-2D012ED1D747

Q37392803-106011F2-08A8-4E87-9365-82EDBDB90615

Q37392803-1AF529D0-7CB5-4AD8-8F21-C0D3FF6BDEF7

Q37392803-1DC00915-DCC3-404E-AC21-B69E783DE1CA

Q37392803-3CF28E52-1C9E-45F3-95F6-08E35FF308B3

Q37392803-3E9E5BA2-3164-43B4-AF92-94358313C468

Q37392803-40B4D07F-B568-4F53-9655-7A32F3A24705

Q37392803-4548C543-7769-4664-B942-894A990CAE51

Q37392803-5028EADE-9C42-4CB9-A139-9059533EDBA0

Q37392803-5EC08363-58A9-4B5A-812B-F3040D8A928A

P304

Q37392803-7A13F324-F41D-4692-BA86-8C97ABCF39CA

P31

Q37392803-9937C2EC-2215-499A-84A2-FD5CD5927AD9

P356

Q37392803-56293577-D818-4176-B231-B322C776C54B

P407

Q37392803-A3EC15B6-93D2-491F-82EF-CBFED8B2F4B9

P433

Q37392803-8CA7F976-98F5-4217-9B6C-EBB25E791C3A

P478

Q37392803-3B6B82FC-4519-4E81-9AAE-8E8045886B1E

P577

Q37392803-E9CAA049-07A0-4AAE-8B59-B9A1496847D5

P698

Q37392803-9EFE5A00-C786-4BAA-A1B4-B83BCFCAD432

P921

Q37392803-B6088A60-7645-48BC-938B-7A7062CD20EF

P932

Q37392803-9C07CCD2-A84B-47F1-A4BB-2BAC5CEBC287

P356

P1433

Antimicrobial Agents and Chemotherapy

P1476

The proteasome inhibitor epoxo ...... arum gametocytocidal activity.

@en

P2093

Beata Czesny

http://www.w3.org/2001/XMLSchema#string

James L Cook

http://www.w3.org/2001/XMLSchema#string

Kim C Williamson

http://www.w3.org/2001/XMLSchema#string

Samrawit Goshu

http://www.w3.org/2001/XMLSchema#string

P2860

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity

Primaquine clears submicroscopic Plasmodium falciparum gametocytes that persist after treatment with sulphadoxine-pyrimethamine and artesunate

Marine actinomycetes: a new source of compounds against the human malaria parasite

Data-mining approaches reveal hidden families of proteases in the genome of malaria parasite

Antimalarial activity of the anticancer and proteasome inhibitor bortezomib and its analog ZL3B

Identification of proteases that regulate erythrocyte rupture by the malaria parasite Plasmodium falciparum.

The Plasmodium circumsporozoite protein is proteolytically processed during cell invasion.

A comprehensive view on proteasomal sequences: implications for the evolution of the proteasome.

Protein database searches using compositionally adjusted substitution matrices

P304

4080-4085

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1128/AAC.00088-09

http://www.w3.org/2001/XMLSchema#string

P407

P433

10

http://www.w3.org/2001/XMLSchema#string

P478

53

http://www.w3.org/2001/XMLSchema#string

P577

2009-08-03T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

19651911

http://www.w3.org/2001/XMLSchema#string

P921

Plasmodium falciparum

P932

2764187

http://www.w3.org/2001/XMLSchema#string