Medicinal chemistry approaches to the inhibition of dipeptidyl peptidase-4 for the treatment of type 2 diabetes.
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Regulation of Chemokine Activity - A Focus on the Role of Dipeptidyl Peptidase IV/CD26Identification of novel human dipeptidyl peptidase-IV inhibitors of natural origin (part I): virtual screening and activity assaysIdentification of novel human dipeptidyl peptidase-IV inhibitors of natural origin (Part II): in silico prediction in antidiabetic extractsPreclinical development of dipeptidyl peptidase IV inhibitor alogliptin: a brief overview.Pharmacology of dipeptidyl peptidase-4 inhibitors: similarities and differences.Medicinal Chemistry and Applications of Incretins and DPP-4 Inhibitors in the Treatment of Type 2 Diabetes Mellitus.Antidiabetic agents: past, present and future.The importance of synthetic drugs for type 2 diabetes drug discovery.Novel DPP-4 inhibitors against diabetes.DPP-4 inhibitors: pharmacological differences and their clinical implications.Novel hydrazine derivatives as selective DPP-IV inhibitors: findings from virtual screening and validation through molecular dynamics simulations.The Place of Dipeptidyl Peptidase-4 Inhibitors in Type 2 Diabetes Therapeutics: A "Me Too" or "the Special One" Antidiabetic Class?Synthesis and Crystallographic Insight into the Structural Aspects of Some Novel Adamantane-Based Ester Derivatives.Design, Synthesis, and in Vitro Evaluation of Novel Aminomethyl-pyridines as DPP-4 Inhibitors.Recent developments in protease activity assays and sensors.Abietane diterpenoids from Caryopteris incana (Thunb.) Miq.Navigating the chemical space of dipeptidyl peptidase-4 inhibitors.Design, Synthesis and Biological Evaluation of N4-Sulfonamido-Succinamic, Phthalamic, Acrylic and Benzoyl Acetic Acid Derivatives as Potential DPP IV Inhibitors.Synthesis of a novel analogue of DPP-4 inhibitor Alogliptin: Introduction of a spirocyclic moiety on the piperidine ring.Improved enzymatic syntheses of valuable beta-arylalkyl-beta-amino acid enantiomers.Synthesis and evaluation of thiouracil derivatives as dipeptidyl peptidase IV inhibitors.Sequential coupling/desilylation-coupling/cyclization in a single pot under Pd/C-Cu catalysis: synthesis of 2-(hetero)aryl indoles.Design, synthesis, structure-activity relationships, and docking studies of 1-(γ-1,2,3-triazol substituted prolyl)-(S)-3,3-difluoropyrrolidines as a novel series of potent and selective dipeptidyl peptidase-4 inhibitors.Design, synthesis, biological evaluation, and docking studies of (s)-phenylalanine derivatives with a 2-cyanopyrrolidine moiety as potent dipeptidyl peptidase 4 inhibitors.Cholinesterase Inhibitory Activities of Adamantyl-Based Derivatives and Their Molecular Docking Studies.Sitagliptin Attenuates Endothelial Dysfunction of Zucker Diabetic Fatty Rats: Implication of the Antiperoxynitrite and Autophagy.Pharmacological Effects and Pharmacokinetic Properties of a Dual-Function Peptide 5rolGLP-HV.Scaffold-based design of xanthine as highly potent inhibitors of DPP-IV for improving glucose homeostasis in DIO mice.In silico screening for identification of pyrrolidine derivatives dipeptidyl peptidase-IV inhibitors using COMFA, CoMSIA, HQSAR and docking studies.Design, Synthesis, and Biological Evaluation of Novel Quinazoline Clubbed Thiazoline Derivatives.
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P2860
Medicinal chemistry approaches to the inhibition of dipeptidyl peptidase-4 for the treatment of type 2 diabetes.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 31 January 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Medicinal chemistry approaches ...... treatment of type 2 diabetes.
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Medicinal chemistry approaches ...... treatment of type 2 diabetes.
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type
label
Medicinal chemistry approaches ...... treatment of type 2 diabetes.
@en
Medicinal chemistry approaches ...... treatment of type 2 diabetes.
@nl
prefLabel
Medicinal chemistry approaches ...... treatment of type 2 diabetes.
@en
Medicinal chemistry approaches ...... treatment of type 2 diabetes.
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P1476
Medicinal chemistry approaches ...... treatment of type 2 diabetes.
@en
P2093
Manojit Pal
Shrikanth H Havale
P304
P356
10.1016/J.BMC.2009.01.061
P407
P577
2009-01-31T00:00:00Z