PKC phosphorylation of titin's PEVK element: a novel and conserved pathway for modulating myocardial stiffness. - Wikidata - wikimedia - TriplyDB

PKC phosphorylation of titin's PEVK element: a novel and conserved pathway for modulating myocardial stiffness.

PKC phosphorylation of titin's PEVK element: a novel and conserved pathway for modulating myocardial stiffness.

http://www.wikidata.org/entity/Q37394610

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A Review of the Giant Protein Titin in Clinical Molecular Diagnostics of Cardiomyopathies Targeting heart failure with preserved ejection fraction: current status and future prospects The role of titin and extracellular matrix remodelling in heart failure with preserved ejection fraction Titin, a Central Mediator for Hypertrophic Signaling, Exercise-Induced Mechanosignaling and Skeletal Muscle Remodeling Signaling effectors underlying pathologic growth and remodeling of the heart Cardiac thin filament regulation and the Frank-Starling mechanism Titin-based tension in the cardiac sarcomere: molecular origin and physiological adaptations Heart failure with preserved ejection fraction Protein kinase C mechanisms that contribute to cardiac remodelling What global diastolic function is, what it is not, and how to measure it Titin-isoform dependence of titin-actin interaction and its regulation by S100A1/Ca2+ in skinned myocardium Single molecule force spectroscopy on titin implicates immunoglobulin domain stability as a cardiac disease mechanism.Excision of titin's cardiac PEVK spring element abolishes PKCalpha-induced increases in myocardial stiffness Heart failure with preserved ejection fraction: molecular pathways of the aging myocardium Genotype-specific pathogenic effects in human dilated cardiomyopathy.Physiologic basis and pathophysiologic implications of the diastolic properties of the cardiac muscle Calcium sensitivity and the Frank-Starling mechanism of the heart are increased in titin N2B region-deficient mice Phosphorylation of tropomodulin1 contributes to the regulation of actin filament architecture in cardiac muscle.Receptor-independent cardiac protein kinase Calpha activation by calpain-mediated truncation of regulatory domains.Probing muscle ankyrin-repeat protein (MARP) structure and function Nebulin deficiency in adult muscle causes sarcomere defects and muscle-type-dependent changes in trophicity: novel insights in nemaline myopathy Acute exercise modifies titin phosphorylation and increases cardiac myofilament stiffness Gene expression, function and ischemia tolerance in male and female rat hearts after sub-toxic levels of angiotensin II.A force-activated kinase in a catch smooth muscle.Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment Contribution of titin and extracellular matrix to passive pressure and measurement of sarcomere length in the mouse left ventricle.The giant protein titin: a regulatory node that integrates myocyte signaling pathways.Redox signaling and cardiac sarcomeres Cardiac titin and heart disease.Increased myocardial stiffness due to cardiac titin isoform switching in a mouse model of volume overload limits eccentric remodeling PKCα-specific phosphorylation of the troponin complex in human myocardium: a functional and proteomics analysis.Protein changes contributing to right ventricular cardiomyocyte diastolic dysfunction in pulmonary arterial hypertension Diastolic myofilament dysfunction in the failing human heart.Titin based viscosity in ventricular physiology: an integrative investigation of PEVK-actin interactions.Emerging importance of oxidative stress in regulating striated muscle elasticity.Hyperphosphorylation of mouse cardiac titin contributes to transverse aortic constriction-induced diastolic dysfunction Protein kinase Cα as a heart failure therapeutic target Titin-actin interaction: PEVK-actin-based viscosity in a large animal Magnitude of length-dependent changes in contractile properties varies with titin isoform in rat ventricles.Cell-intrinsic functional effects of the α-cardiac myosin Arg-403-Gln mutation in familial hypertrophic cardiomyopathy.

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PKC phosphorylation of titin's PEVK element: a novel and conserved pathway for modulating myocardial stiffness.

http://www.wikidata.org/entity/Q37394610

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article científic

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 13 August 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

PKC phosphorylation of titin's ...... dulating myocardial stiffness.

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PKC phosphorylation of titin's ...... dulating myocardial stiffness.

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type

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PKC phosphorylation of titin's ...... dulating myocardial stiffness.

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PKC phosphorylation of titin's ...... dulating myocardial stiffness.

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PKC phosphorylation of titin's ...... dulating myocardial stiffness.

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PKC phosphorylation of titin's ...... dulating myocardial stiffness.

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CIRCRESAHA.109.198465

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Circulation Research

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PKC phosphorylation of titin's ...... dulating myocardial stiffness.

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Brian Anderson

http://www.w3.org/2001/XMLSchema#string

Bryan Hudson

http://www.w3.org/2001/XMLSchema#string

Carlos Hidalgo

http://www.w3.org/2001/XMLSchema#string

Henk Granzier

http://www.w3.org/2001/XMLSchema#string

Julius Bogomolovas

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Marion Greaser

http://www.w3.org/2001/XMLSchema#string

Siegfried Labeit

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Yi Zhu

http://www.w3.org/2001/XMLSchema#string

P2860

The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system

Multiple conformations of PEVK proteins detected by single-molecule techniques.

Passive tension in cardiac muscle: contribution of collagen, titin, microtubules, and intermediate filaments

Molecular dissection of N2B cardiac titin's extensibility

Mechanical fatigue in repetitively stretched single molecules of titin.

The giant protein titin: a major player in myocardial mechanics, signaling, and disease.

Protein kinase C in cardiac disease and as a potential therapeutic target.

Titin and its associated proteins: the third myofilament system of the sarcomere.

Phosphorylation of titin modulates passive stiffness of cardiac muscle in a titin isoform-dependent manner.

Calcium-dependent molecular spring elements in the giant protein titin

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631-8, 17 p following 638

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scholarly article

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10.1161/CIRCRESAHA.109.198465

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7

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105

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2009-08-13T00:00:00Z

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19679839

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phosphorylation

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2764991

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