Contact with fibrillar collagen inhibits melanoma cell proliferation by up-regulating p27KIP1
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Integrin alpha 2 beta 1 promotes activation of protein phosphatase 2A and dephosphorylation of Akt and glycogen synthase kinase 3 beta.The cyclin-dependent kinase inhibitors p15INK4B and p21CIP1 are critical regulators of fibrillar collagen-induced tumor cell cycle arrestDiscoidin domain receptor 2 mediates tumor cell cycle arrest induced by fibrillar collagenLoss of cellular adhesion to matrix induces p53-independent expression of PTEN tumor suppressorDiscoidin Domain Receptors: Potential Actors and Targets in CancerA membrane-type-1 matrix metalloproteinase (MT1-MMP)-discoidin domain receptor 1 axis regulates collagen-induced apoptosis in breast cancer cellsMutant B-RAF signaling and cyclin D1 regulate Cks1/S-phase kinase-associated protein 2-mediated degradation of p27Kip1 in human melanoma cellsPhosphoproteomics of collagen receptor networks reveals SHP-2 phosphorylation downstream of wild-type DDR2 and its lung cancer mutantsProgesterone modulates integrin {alpha}2 (ITGA2) and {alpha}11 (ITGA11) in the pregnant cervixAuditory hair cell-specific deletion of p27Kip1 in postnatal mice promotes cell-autonomous generation of new hair cells and normal hearing.The stiffness of collagen fibrils influences vascular smooth muscle cell phenotype.Dormancy of metastatic melanomaExtracellular matrix: a gatekeeper in the transition from dormancy to metastatic growthThe antifibrotic drug halofuginone inhibits proliferation and collagen production by human leiomyoma and myometrial smooth muscle cellsMolecular pathways: niches in metastatic dormancyRole of secreted type I collagen derived from stromal cells in two breast cancer cell lines.KLF6 Gene and early melanoma development in a collagen I-rich extracellular environment.Akt3-mediated resistance to apoptosis in B-RAF-targeted melanoma cells.MYCN-dependent expression of sulfatase-2 regulates neuroblastoma cell survival.Extracellular matrix collagen alters cell proliferation and cell cycle progression of human uterine leiomyoma smooth muscle cellsProgression in cutaneous malignant melanoma is associated with distinct expression profiles: a tissue microarray-based study.Recombinant alpha2(IV)NC1 domain inhibits tumor cell-extracellular matrix interactions, induces cellular senescence, and inhibits tumor growth in vivo.Microenvironmental control of the breast cancer cell cycle.S-phase delay in human hepatocellular carcinoma cells induced by overexpression of integrin beta1The mesenchymal tumor microenvironment: a drug-resistant niche.Three-dimensional collagen represses cyclin E1 via β1 integrin in invasive breast cancer cells.Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton.Type I collagen aging impairs discoidin domain receptor 2-mediated tumor cell growth suppressionThe BRAF(V600E) inhibitor, PLX4032, increases type I collagen synthesis in melanoma cells3D/4D functional imaging of tumor-associated proteolysis: impact of microenvironment.Biochemical role of the collagen-rich tumour microenvironment in pancreatic cancer progression.Discoidin domain receptor 2 signaling networks and therapy in lung cancer.Expression of cell cycle inhibitor p27Kip1 and its inactivator Jab1 in melanocytic lesions.Gene expression profile of the hippocampus of rats subjected to chronic immobilization stress.Immunogenic, cellular, and angiogenic drivers of tumor dormancy--a melanoma view.MT1-MMP protects breast carcinoma cells against type I collagen-induced apoptosis.Delay of cell cycle progression and induction death of cancer cells on type I collagen fibrils [corrected].Integrin beta1 subunit overexpressed in the SMMC-7721 cells regulates the promoter activity of p21(CIP1) and enhances its transcription.Rigidity of collagen fibrils controls collagen gel-induced down-regulation of focal adhesion complex proteins mediated by alpha2beta1 integrin.Malignant transformation of melanocytes to melanoma by constitutive activation of mitogen-activated protein kinase kinase (MAPKK) signaling.
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Contact with fibrillar collagen inhibits melanoma cell proliferation by up-regulating p27KIP1
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on August 2000
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Contact with fibrillar collage ...... ation by up-regulating p27KIP1
@en
Contact with fibrillar collage ...... tion by up-regulating p27KIP1.
@nl
type
label
Contact with fibrillar collage ...... ation by up-regulating p27KIP1
@en
Contact with fibrillar collage ...... tion by up-regulating p27KIP1.
@nl
prefLabel
Contact with fibrillar collage ...... ation by up-regulating p27KIP1
@en
Contact with fibrillar collage ...... tion by up-regulating p27KIP1.
@nl
P2093
P2860
P356
P1476
Contact with fibrillar collage ...... ation by up-regulating p27KIP1
@en
P2093
K I Weinberg
P C Brooks
Y A DeClerck
P2860
P304
10026-10031
P356
10.1073/PNAS.170290997
P407
P577
2000-08-01T00:00:00Z