Intranasal administration of IGF-1 attenuates hypoxic-ischemic brain injury in neonatal rats.
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The rostral migratory stream plays a key role in intranasal delivery of drugs into the CNSIntranasal insulin therapy for cognitive impairment and neurodegeneration: current state of the artRevisiting the timing hypothesis: biomarkers that define the therapeutic window of estrogen for strokeOligodendroglial alterations and the role of microglia in white matter injury: relevance to schizophrenia.Neurodevelopmental effects of insulin-like growth factor signaling.The neurotoxic effects of estrogen on ischemic stroke in older female rats is associated with age-dependent loss of insulin-like growth factor-1.Blunting type 1 insulin-like growth factor receptor expression exacerbates neuronal apoptosis following hypoxic/ischemic injuryThe IGF-derived tripeptide Gly-Pro-Glu is a weak NMDA receptor agonistAn antagomir to microRNA Let7f promotes neuroprotection in an ischemic stroke model.Estrogen-IGF-1 interactions in neuroprotection: ischemic stroke as a case study.IGF-1 promotes Brn-4 expression and neuronal differentiation of neural stem cells via the PI3K/Akt pathwayThe effect of osteopontin and osteopontin-derived peptides on preterm brain injuryWhole body hypothermia broadens the therapeutic window of intranasally administered IGF-1 in a neonatal rat model of cerebral hypoxia-ischemia.Pharmacological neuroprotection after perinatal hypoxic-ischemic brain injuryBlood brain barrier and neuroinflammation are critical targets of IGF-1-mediated neuroprotection in stroke for middle-aged female rats.Intranasal administration of insulin-like growth factor-1 protects against lipopolysaccharide-induced injury in the developing rat brain.PINK1 enhances insulin-like growth factor-1-dependent Akt signaling and protection against apoptosis.Combination treatment with ethyl pyruvate and IGF-I exerts neuroprotective effects against brain injury in a rat model of neonatal hypoxic-ischemic encephalopathyG-CSF attenuates neuroinflammation and stabilizes the blood-brain barrier via the PI3K/Akt/GSK-3β signaling pathway following neonatal hypoxia-ischemia in rats.DOR activation inhibits anoxic/ischemic Na+ influx through Na+ channels via PKC mechanisms in the cortexIntranasal insulin protects against substantia nigra dopaminergic neuronal loss and alleviates motor deficits induced by 6-OHDA in ratsIGF-1 acts as controlling switch for long-term proliferation and maintenance of EGF/FGF-responsive striatal neural stem cellsNeuroprotection in the newborn infantErythropoietin for infants with hypoxic-ischemic encephalopathy.Pharmacological neuroprotection after perinatal asphyxia.Intranasal erythropoietin therapy in nervous system disorders.Stroke neuroprotection: oestrogen and insulin-like growth factor-1 interactions and the role of microglia.Dietary proteins and IGF I levels in preterm infants: determinants of growth, body composition, and neurodevelopment.Pharmacological approaches to intervention in hypomyelinating and demyelinating white matter pathology.Intranasal gene delivery for treating Parkinson's disease: overcoming the blood-brain barrier.Intranasal surfactant protein D as neuroprotective rescue in a neonatal rat model of periventricular leukomalacia.IGF-1 in retinopathy of prematurity, a CNS neurovascular disease.Perinatal Brain Injury As a Consequence of Preterm Birth and Intrauterine Inflammation: Designing Targeted Stem Cell Therapies.Intranasally administered IGF-1 inhibits spreading depression in vivo.Circulatory insulin-like growth factor-I and brain volumes in relation to neurodevelopmental outcome in very preterm infants.Neuroprotective Effects of Intranasal IGF-1 against Neonatal Lipopolysaccharide-Induced Neurobehavioral Deficits and Neuronal Inflammation in the Substantia Nigra and Locus Coeruleus of Juvenile Rats.Effect of insulin-like growth factor-I during the early postnatal period in intrauterine growth-restricted rats.
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Intranasal administration of IGF-1 attenuates hypoxic-ischemic brain injury in neonatal rats.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 28 March 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Intranasal administration of I ...... brain injury in neonatal rats.
@en
Intranasal administration of I ...... brain injury in neonatal rats.
@nl
type
label
Intranasal administration of I ...... brain injury in neonatal rats.
@en
Intranasal administration of I ...... brain injury in neonatal rats.
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prefLabel
Intranasal administration of I ...... brain injury in neonatal rats.
@en
Intranasal administration of I ...... brain injury in neonatal rats.
@nl
P2093
P2860
P1476
Intranasal administration of I ...... brain injury in neonatal rats.
@en
P2093
Lir-Wan Fan
Philip G Rhodes
Shuying Lin
Zhengwei Cai
P2860
P304
P356
10.1016/J.EXPNEUROL.2009.03.021
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P577
2009-03-28T00:00:00Z