Role of protein kinase C epsilon (PKCvarepsilon) in the reduction of ethanol reinforcement due to mGluR5 antagonism in the nucleus accumbens shell.
about
Glutamatergic targets for new alcohol medicationsThe metabotropic glutamate 5 receptor modulates extinction and reinstatement of methamphetamine-seeking in miceCognitive effects of Group I metabotropic glutamate receptor ligands in the context of drug addiction.Behavioral and functional evidence of metabotropic glutamate receptor 2/3 and metabotropic glutamate receptor 5 dysregulation in cocaine-escalated rats: factor in the transition to dependenceProtein kinase C isozymes as regulators of sensitivity to and self-administration of drugs of abuse-studies with genetically modified mice.Recent advances in the design and development of novel negative allosteric modulators of mGlu(5)Metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) microinfusions into the nucleus accumbens shell or ventral tegmental area attenuate the reinforcing effects of nicotine in ratsEnhanced sensitivity to attenuation of conditioned reinstatement by the mGluR 2/3 agonist LY379268 and increased functional activity of mGluR 2/3 in rats with a history of ethanol dependenceDifferential Modulation of Thresholds for Intracranial Self-Stimulation by mGlu5 Positive and Negative Allosteric Modulators: Implications for Effects on Drug Self-Administration.Changes in extracellular levels of glutamate in the nucleus accumbens after ethanol-induced behavioral sensitization in adolescent and adult mice.mGluR5 receptors in the basolateral amygdala and nucleus accumbens regulate cue-induced reinstatement of ethanol-seeking behaviorRGS4 overexpression in the rat dorsal striatum modulates mGluR5- and amphetamine-mediated behavior and signaling.mGlu receptors and drug addiction.Binge Drinking With Protein Kinase C Epsilon: A Role for Mammalian Target of Rapamycin Complex 2?Deficits in ventromedial prefrontal cortex group 1 metabotropic glutamate receptor function mediate resistance to extinction during protracted withdrawal from an extensive history of cocaine self-administrationNeuroscience of alcoholism: molecular and cellular mechanismsThe role of ventral and dorsal striatum mGluR5 in relapse to cocaine-seeking and extinction learning.The Effect of mGluR5 Antagonism During Binge Drinkingon Subsequent Ethanol Intake in C57BL/6J Mice: Sex- and Age-Induced DifferencesBinge drinking upregulates accumbens mGluR5-Homer2-PI3K signaling: functional implications for alcoholism.Adolescent Mice Are Resilient to Alcohol Withdrawal-Induced Anxiety and Changes in Indices of Glutamate Function within the Nucleus Accumbens.mGluR1 within the nucleus accumbens regulates alcohol intake in mice under limited-access conditions.mGlu5 negative allosteric modulators: a patent review (2010-2012).mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Metabotropic and ionotropic glutamate receptors as potential targets for the treatment of alcohol use disorder.N-Alkylpyrido[1',2':1,5]pyrazolo-[4,3-d]pyrimidin-4-amines: A new series of negative allosteric modulators of mGlu1/5 with CNS exposure in rodents.Protein Kinase C Epsilon Activity in the Nucleus Accumbens and Central Nucleus of the Amygdala Mediates Binge Alcohol Consumption.Increased extracellular glutamate in the nucleus accumbens promotes excessive ethanol drinking in ethanol dependent miceDiscovery of VU0409106: A negative allosteric modulator of mGlu5 with activity in a mouse model of anxietyDiscovery of VU0431316: a negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety.Metabotropic glutamate receptor 5 binding in male patients with alcohol use disorder.Protein kinase Cɛ activity regulates mGluR5 surface expression in the rat nucleus accumbens.Potentiation of amygdala AMPA receptor activity selectively promotes escalated alcohol self-administration in a CaMKII-dependent manner.
P2860
Q26824012-01283089-0CEB-49E0-AAFF-821A8C0F82E3Q28534521-508C81AF-A305-43CF-B064-7FBAAC69E881Q33936309-8837D2C4-3C37-4FB0-8049-742960DF75B6Q34009072-D2880BDD-B535-40FA-BA18-6A5908D1CC3AQ34761380-3AF2B186-4058-4634-AA99-6B07E244D179Q35210746-1D46BA9F-CEC8-4C9F-A2E2-965AFA6FCC2FQ35291239-1A4BFDC9-D19A-41E4-B4C9-6E90CD48194FQ35592069-B1B3BEFF-3BDA-450C-97AE-0AA3811BF12CQ35657336-4DCAEBEC-AAE5-41CB-AE61-30D825F6132AQ35846119-8FA5E2B4-A916-4BCA-A400-11E5C6CCDFA9Q35846295-78C7E2AC-F70A-4C19-8B7A-75CDCEB7E192Q35867186-055C845D-D5CE-4729-B944-9A75911E7320Q35999502-F95794C7-7A67-44A5-A65F-0910E3C3E148Q37007804-8E8609AF-1F2E-469B-96A3-C716370A24FEQ37013642-5AD1E24B-3707-45EA-80E0-6C4D45C55169Q37106625-A5D54B1B-079B-4E77-9C0F-4AED80C66624Q37146824-13812E35-0B7B-42FC-B068-675D0CD74F0BQ37294421-45A0A70C-0800-4C4D-8563-0E535276ACB4Q37386920-56492F66-1379-4DB3-9A97-1ABB5480A3E6Q37421133-C78DD254-3069-4263-9FC5-8510E1684F57Q37642997-384D7AB5-6ED8-42A2-B447-2C94949C3770Q38075897-5D45EC0B-83CB-4954-AFD7-C8BBC583910BQ39076410-D56D70ED-8FC1-4596-BFC2-DFF1E2BB6DF4Q39153205-249F0275-F59C-41FC-B388-9549FB9B36BDQ39955646-D9669543-802B-44AC-B38E-80853AD6D95CQ41091103-DC426851-CDBA-4A0A-8C7B-C9CCA83C73A1Q41878151-B33E20F6-C66C-439D-9B4E-09C61CA8E93AQ41891138-E5944418-889F-4CD3-8000-A88D611F11C9Q42728918-D0E4B91A-B638-42B1-861A-B9FBF40FF44FQ47215698-84115AF1-7315-42F8-B3B4-DA2F9DC34168Q48559262-81B4A8BF-6F60-4F70-8B2A-75313EB638E1Q49028290-3997044E-23F2-4B15-9C05-713C4F5E0A68
P2860
Role of protein kinase C epsilon (PKCvarepsilon) in the reduction of ethanol reinforcement due to mGluR5 antagonism in the nucleus accumbens shell.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 19 February 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Role of protein kinase C epsil ...... n the nucleus accumbens shell.
@en
Role of protein kinase C epsilon
@nl
type
label
Role of protein kinase C epsil ...... n the nucleus accumbens shell.
@en
Role of protein kinase C epsilon
@nl
prefLabel
Role of protein kinase C epsil ...... n the nucleus accumbens shell.
@en
Role of protein kinase C epsilon
@nl
P2860
P1433
P1476
Role of protein kinase C epsil ...... in the nucleus accumbens shell
@en
P2093
Justin T Gass
P2860
P2888
P304
P356
10.1007/S00213-009-1490-Y
P577
2009-02-19T00:00:00Z