Obesity-related elevations in plasma leucine are associated with alterations in enzymes involved in branched-chain amino acid metabolism.
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Interplay between lipids and branched-chain amino acids in development of insulin resistanceReviewing the Effects of L-Leucine Supplementation in the Regulation of Food Intake, Energy Balance, and Glucose HomeostasisInvestigating potential mechanisms of obesity by metabolomicsThe pathogenic role of persistent milk signaling in mTORC1- and milk-microRNA-driven type 2 diabetes mellitusThe Relationship between Branched-Chain Amino Acid Related Metabolomic Signature and Insulin Resistance: A Systematic ReviewBenzothiophene carboxylate derivatives as novel allosteric inhibitors of branched-chain α-ketoacid dehydrogenase kinaseBranched-chain amino acids in metabolic signalling and insulin resistanceIncreased plasma citrulline in mice marks diet-induced obesity and may predict the development of the metabolic syndromeArginase promotes endothelial dysfunction and hypertension in obese ratsPlasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American womenType 2 diabetes associated changes in the plasma non-esterified fatty acids, oxylipins and endocannabinoidsBranched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine exportLeucine signaling in the pathogenesis of type 2 diabetes and obesityThe Complex Roles of Mechanistic Target of Rapamycin in Adipocytes and Beyond.Leucine facilitates insulin signaling through a Gαi protein-dependent signaling pathway in hepatocytes.Metabolite profiling identifies candidate markers reflecting the clinical adaptations associated with Roux-en-Y gastric bypass surgery.Leucine supplementation of drinking water does not alter susceptibility to diet-induced obesity in mice.Relation of body fat indexes to vitamin D status and deficiency among obese adolescentsGC-TOF/MS-based metabolomic profiling of estrogen deficiency-induced obesity in ovariectomized rats.Adipose tissue branched chain amino acid (BCAA) metabolism modulates circulating BCAA levels.Leucine Supplementation Differently Modulates Branched-Chain Amino Acid Catabolism, Mitochondrial Function and Metabolic Profiles at the Different Stage of Insulin Resistance in Rats on High-Fat Diet.Effects of leucine supplementation and serum withdrawal on branched-chain amino acid pathway gene and protein expression in mouse adipocytes.Comparative analysis of the human hepatic and adipose tissue transcriptomes during LPS-induced inflammation leads to the identification of differential biological pathways and candidate biomarkers.Voluntary exercise under a food restriction condition decreases blood branched-chain amino acid levels, in addition to improvement of glucose and lipid metabolism, in db mice, animal model of type 2 diabetesToward a unifying hypothesis of metabolic syndrome.Multi-tissue, selective PPARγ modulation of insulin sensitivity and metabolic pathways in obese rats.Determination of the safety of leucine supplementation in healthy elderly men.Hyperleucinemia causes hippocampal retromer deficiency linking diabetes to Alzheimer's disease.Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism.Leucine and protein metabolism in obese Zucker rats.Milk consumption during pregnancy increases birth weight, a risk factor for the development of diseases of civilizationAdipose tissue monomethyl branched-chain fatty acids and insulin sensitivity: Effects of obesity and weight loss.Oral leucine supplementation is sensed by the brain but neither reduces food intake nor induces an anorectic pattern of gene expression in the hypothalamus.Serum glycine is associated with regional body fat and insulin resistance in functionally-limited older adultsBranched chain amino acid metabolism profiles in progressive human nonalcoholic fatty liver disease.Lactating porcine mammary tissue catabolizes branched-chain amino acids for glutamine and aspartate synthesisBranched-chain amino acids, mitochondrial biogenesis, and healthspan: an evolutionary perspective.Effects of acute exposure to increased plasma branched-chain amino acid concentrations on insulin-mediated plasma glucose turnover in healthy young subjects.Diabetes risk and amino acid profiles: cross-sectional and prospective analyses of ethnicity, amino acids and diabetes in a South Asian and European cohort from the SABRE (Southall And Brent REvisited) Study.Metabolomic analysis reveals altered skeletal muscle amino acid and fatty acid handling in obese humans.
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P2860
Obesity-related elevations in plasma leucine are associated with alterations in enzymes involved in branched-chain amino acid metabolism.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 09 October 2007
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Obesity-related elevations in ...... d-chain amino acid metabolism.
@en
Obesity-related elevations in ...... d-chain amino acid metabolism.
@nl
type
label
Obesity-related elevations in ...... d-chain amino acid metabolism.
@en
Obesity-related elevations in ...... d-chain amino acid metabolism.
@nl
prefLabel
Obesity-related elevations in ...... d-chain amino acid metabolism.
@en
Obesity-related elevations in ...... d-chain amino acid metabolism.
@nl
P2093
P2860
P1476
Obesity-related elevations in ...... ed-chain amino acid metabolism
@en
P2093
Cynthia Van Horn
Pengxiang She
Robert N Cooney
Susan M Hutson
Tanya Reid
P2860
P304
P356
10.1152/AJPENDO.00134.2007
P577
2007-10-09T00:00:00Z