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Single application of a CB1 receptor antagonist rapidly following head injury prevents long-term hyperexcitability in a rat model

Single application of a CB1 receptor antagonist rapidly following head injury prevents long-term hyperexcitability in a rat model

http://www.wikidata.org/entity/Q37399998

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Epilepsy related to traumatic brain injury.Cannabinoids and Epilepsy.Pursuing paradoxical proconvulsant prophylaxis for epileptogenesis Statistical parametric mapping reveals regional alterations in cannabinoid CB1 receptor distribution and G-protein activation in the 3D reconstructed epileptic rat brain.The potential of antiseizure drugs and agents that act on novel molecular targets as antiepileptogenic treatments.ADC mapping and T1-weighted signal changes on post-injury MRI predict seizure susceptibility after experimental traumatic brain injury.Dentate cannabinoid-sensitive interneurons undergo unique and selective strengthening of mutual synaptic inhibition in experimental epilepsy.Astrocytic expression of cannabinoid type 1 receptor in rat and human sclerotic hippocampi.The effect of the cannabinoid-receptor antagonist, SR141716, on the early stage of kainate-induced epileptogenesis in the adult rat.Redistribution of CB1 cannabinoid receptors in the acute and chronic phases of pilocarpine-induced epilepsy Prevention or modification of epileptogenesis after brain insults: experimental approaches and translational research.Cannabinoid receptor 1 blockade protects human retinal pigment epithelial cells from oxidative injury.Past and present definitions of epileptogenesis and its biomarkers.Therapeutic approaches to epileptogenesis--hope on the horizon.Marijuana, endocannabinoids, and epilepsy: potential and challenges for improved therapeutic intervention.Neural circuit mechanisms of post-traumatic epilepsy.The potential role of cannabinoids in epilepsy treatment.Enhanced Dentate Neurogenesis after Brain Injury Undermines Long-Term Neurogenic Potential and Promotes Seizure Susceptibility.Therapeutic effects of cannabinoids in animal models of seizures, epilepsy, epileptogenesis, and epilepsy-related neuroprotection.CB1 receptor antagonism impairs the induction of epileptiform activity by group I metabotropic glutamate receptor activation.Posttraumatic Epilepsy: What's Contusion Got to Do With It?Do proconvulsants modify or halt epileptogenesis? Pentylenetetrazole is ineffective in two rat models of temporal lobe epilepsy.Effects of Human ES-Derived Neural Stem Cell Transplantation and Kindling in a Rat Model of Traumatic Brain Injury.Disease-modifying effects of RHC80267 and JZL184 in a pilocarpine mouse model of temporal lobe epilepsy.

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Single application of a CB1 receptor antagonist rapidly following head injury prevents long-term hyperexcitability in a rat model

http://www.wikidata.org/entity/Q37399998

description

article científic

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 15 April 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Single application of a CB1 re ...... perexcitability in a rat model

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Single application of a CB1 re ...... erexcitability in a rat model.

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Single application of a CB1 re ...... perexcitability in a rat model

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Single application of a CB1 re ...... erexcitability in a rat model.

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Single application of a CB1 re ...... perexcitability in a rat model

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Single application of a CB1 re ...... erexcitability in a rat model.

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J.EPLEPSYRES.2009.02.019

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Epilepsy Research

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Single application of a CB1 re ...... perexcitability in a rat model

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Ivan Soltesz

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Julio Echegoyen

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Robert J Morgan

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P2860

Posttraumatic epilepsy: a major problem in desperate need of major advances

Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials.

Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial.

Prevalence of epilepsy in Rochester, Minnesota: 1940-1980.

Endocannabinoid signaling as a synaptic circuit breaker in neurological disease.

Prevention of plasticity of endocannabinoid signaling inhibits persistent limbic hyperexcitability caused by developmental seizures.

Granule cell hyperexcitability in the early post-traumatic rat dentate gyrus: the 'irritable mossy cell' hypothesis.

Post-traumatic epilepsy following fluid percussion injury in the rat.

Selective vulnerability of dentate hilar neurons following traumatic brain injury: a potential mechanistic link between head trauma and disorders of the hippocampus.

The endocannabinoid system controls key epileptogenic circuits in the hippocampus.

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scholarly article

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10.1016/J.EPLEPSYRES.2009.02.019

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1

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Caren Armstrong

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2009-04-15T00:00:00Z

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19369036

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