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Metabolic glycoengineering: sialic acid and beyond

Metabolic glycoengineering: sialic acid and beyond

http://www.wikidata.org/entity/Q37405391

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Current Status: Site-Specific Antibody Drug Conjugates Advancement of Sialyltransferase Inhibitors: Therapeutic Challenges and Opportunities Metabolically incorporated photocrosslinking sialic acid covalently captures a ganglioside-protein complex.Peptide and glycopeptide dendrimers and analogous dendrimeric structures and their biomedical applications.Effects of altered sialic acid biosynthesis on N-linked glycan branching and cell surface interactions Metabolism of diazirine-modified N-acetylmannosamine analogues to photo-cross-linking sialosides.Abrogation of neuraminidase reduces biofilm formation, capsule biosynthesis, and virulence of Porphyromonas gingivalis.UDP-GlcNAc 2-Epimerase/ManNAc Kinase (GNE): A Master Regulator of Sialic Acid Synthesis.Multifarious roles of sialic acids in immunity.Carbohydrate engineered cells for regenerative medicine.Development of delivery methods for carbohydrate-based drugs: controlled release of biologically-active short chain fatty acid-hexosamine analogs Designing a binding interface for control of cancer cell adhesion via 3D topography and metabolic oligosaccharide engineering.Tissue-based metabolic labeling of polysialic acids in living primary hippocampal neurons.Site-specific antibody-drug conjugates: the nexus of bioorthogonal chemistry, protein engineering, and drug development Bioorthogonal chemical reporter methodology for visualization, isolation and analysis of glycoconjugates Deciphering glycan linkages involved in Jurkat cell interactions with gold-coated nanofibers via sugar-displayed thiols.Modified GM3 gangliosides produced by metabolic oligosaccharide engineering Dynamic Sialylation in Transforming Growth Factor-β (TGF-β)-induced Epithelial to Mesenchymal Transition.Identification of sialylated glycoproteins from metabolically oligosaccharide engineered pancreatic cells.Sialidases as regulators of bioengineered cellular surfaces.Metabolic oligosaccharide engineering with N-Acyl functionalized ManNAc analogs: cytotoxicity, metabolic flux, and glycan-display considerations Successful prediction of substrate-binding pocket in SLC17 transporter sialin.Metabolic flux increases glycoprotein sialylation: implications for cell adhesion and cancer metastasis.Cellular metabolism of unnatural sialic acid precursors.Nutrient-deprived cancer cells preferentially use sialic acid to maintain cell surface glycosylation.Fluorogenic sialic acid glycosides for quantification of sialidase activity upon unnatural substrates.Extracellular and intracellular esterase processing of SCFA-hexosamine analogs: implications for metabolic glycoengineering and drug delivery.Sialic acid metabolism and sialyltransferases: natural functions and applications.Photocrosslinking approaches to interactome mapping.Development of orally active inhibitors of protein and cellular fucosylation Imaging beyond the proteome Metabolic glycoengineering of mesenchymal stromal cells with N-propanoylmannosamine Preferential lectin binding of cancer cells upon sialic acid treatment under nutrient deprivation A Two-Photon Excitation Based Fluorogenic Probe for Sialome Imaging in Living Systems.Cell labeling and tracking method without distorted signals by phagocytosis of macrophages.Monitoring dynamic glycosylation in vivo using supersensitive click chemistry Metabolic oligosaccharide engineering: implications for selectin-mediated adhesion and leukocyte extravasation.Chemical tools to explore nutrient-driven O-GlcNAc cycling.Cell-Surface Glyco-Engineering by Exogenous Enzymatic Transfer using a Bi-Functional CMP-Neu5Ac Derivative.Residue-centric modeling and design of saccharide and glycoconjugate structures.

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Metabolic glycoengineering: sialic acid and beyond

http://www.wikidata.org/entity/Q37405391

description

article científic

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article scientifique

@fr

articolo scientifico

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artigo científico

@pt

bilimsel makale

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scientific article published on 12 August 2009

@en

vedecký článok

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vetenskaplig artikel

@sv

videnskabelig artikel

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vědecký článek

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name

Metabolic glycoengineering: sialic acid and beyond

@en

Metabolic glycoengineering: sialic acid and beyond.

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type

label

Metabolic glycoengineering: sialic acid and beyond

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Metabolic glycoengineering: sialic acid and beyond.

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Metabolic glycoengineering: sialic acid and beyond

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Metabolic glycoengineering: sialic acid and beyond.

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Metabolic glycoengineering: sialic acid and beyond

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Hargun S Khanna

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Kevin J Yarema

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Venkata D P Paruchuri

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Zhiyun Wang

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P2860

Sulfotransferases of two specificities function in the reconstitution of high endothelial cell ligands for L-selectin

UDP-GlcNAc 2-epimerase: a regulator of cell surface sialylation

Cloning and expression of the human N-acetylneuraminic acid phosphate synthase gene with 2-keto-3-deoxy-D-glycero- D-galacto-nononic acid biosynthetic ability

Molecular cloning and characterization of murine and human N-acetylglucosamine kinase

A mutation in human CMP-sialic acid hydroxylase occurred after the Homo-Pan divergence

Inactivation of CMP-N-acetylneuraminic acid hydroxylase occurred prior to brain expansion during human evolution

From genomics to chemical genomics: new developments in KEGG

Mutations in the human UDP-N-acetylglucosamine 2-epimerase gene define the disease sialuria and the allosteric site of the enzyme

Exploring the O-GlcNAc proteome: direct identification of O-GlcNAc-modified proteins from the brain

Copper-free click chemistry for dynamic in vivo imaging

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1382-1401

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scholarly article

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10.1093/GLYCOB/CWP115

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12

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19

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Michael Adam Meledeo

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2009-08-12T00:00:00Z

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26736487

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19675091

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2770326

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